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Human Recombinant PEDF (from E. coli)

Supplier: Peprotech

Description: PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors, such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity ( Notari, I. et al. J Biol Chem., Vol. 281, 38022-38037 ) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature-related neurodegenerative diseases, such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant Human PEDF is a 44.5 kDa non-glycosylated protein containing 400 amino acid residues.

Sodium sulfate, anhydrous ≥99.0%, powder, BAKER ANALYZED® ACS, J.T.Baker®

Supplier: AVANTOR PERFORMANCE MATERIAL LLC

Description: Powder. Lot analysis on label.

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Sodium chloride ≥99% (by argentometric titration), crystals, AR® (ACS) Salts ACS, Macron Fine Chemicals™

Supplier: AVANTOR PERFORMANCE MATERIAL LLC

Description: AR—The standard Macron Fine Chemicals™ grade of analytical reagents; suitable for laboratory and general use.

SDS Certificates

Sodium chloride 99.0-100.5% (dry basis), granular FCC, USP, J.T.Baker®

Supplier: AVANTOR PERFORMANCE MATERIAL LLC

Description: White crystals or granules. Must be subjected to further processing during the preparation of injectable dosage forms. Meets USP and FCC requirements. GMP manufactured product. Preserve in tightly sealed containers.

SDS Certificates

Sodium hydrogen carbonate 99.0-100.5% (by acidimetry on anhydrous substance), powder USP, FCC for haemodialysis, Macron Fine Chemicals™

Supplier: AVANTOR PERFORMANCE MATERIAL LLC

Description: pH adjusters are used to adjust the pH of formulations.

SDS Certificates

Anti-MAPK8 / MAPK9 / MAPK10 Rabbit Polyclonal Antibody

Catalog Number: (10070-936)

Supplier: Prosci

Description: Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it./Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity

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Sodium chloride 99.0-100.5% (dried basis), granular USP, Multi-Compendial, J.T.Baker®

Supplier: AVANTOR PERFORMANCE MATERIAL LLC

Description: Granular. GMP manufactured product.

SDS Certificates

Disodium hydrogen phosphate, anhydrous ≥99.0% (by acidimetry), BAKER ANALYZED® ACS, J.T.Baker®

Supplier: AVANTOR PERFORMANCE MATERIAL LLC

Description: Disodium hydrogen phosphate. CAS RN 7558-79-4. Anhydrous, powder, 'BAKER ANALYZED'* Reagent, 99.0% min. For buffer solutions. Meets ACS specifications. Lot analysis on label. Packaged in a plastic container. Subject to postal/shipping restrictions. 2.5kg.

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Sodium carbonate, anhydrous 99.5-100.5% (by anhydrous basis), granular NF, FCC, J.T.Baker®

Supplier: AVANTOR PERFORMANCE MATERIAL LLC

Description: pH adjusters are used to adjust the pH of formulations.

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Disodium hydrogen phosphate heptahydrate 98.0-102.0%, crystals, BAKER ANALYZED® ACS, J.T.Baker®

Supplier: AVANTOR PERFORMANCE MATERIAL LLC

Description: Achieve control over laboratory variables -- minimizing variability and maximizing consistency of results -- by relying on salts in a variety of grades - ACS, BAKER, etc.

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Sodium chloride 99.0-100.5% (dried basis), granular USP, Multi-Compendial, J.T.Baker®

Catalog Number: (CAJT3625-07)

Supplier: AVANTOR PERFORMANCE MATERIAL LLC

Description: Sodium chloride 99.0-100.5% (dried basis), granular USP, Multi-Compendial, J.T.Baker®

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Disodium hydrogen phosphate heptahydrate 98-100.0% (dried basis), crystals USP, J.T.Baker®

Supplier: AVANTOR PERFORMANCE MATERIAL LLC

Description: Avantor excipients are used during the formulation process in a wide range of applications. Avantor provides high-purity and performance excipients that serve as fillers, binders, disintegrants, lubicants, flavors, emulsifiers and preservatives. All the products are cGMP produced and meet USP grade standards.

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