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Image Unavailable-10668-812

Anti-SEMCAP3 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10668-812)
Supplier: Bioss
Description: PDZRN3 contains a RING-finger motif in its N-terminal region, two PDZ domains in its central region and a consensus-binding motif for PDZ domains at its C-terminus. It was identified in silico as a homolog of the protein known as LNX1 or SEMCAP1, which possesses ubiquitin ligase activity and binds the membrane protein Semaphorin 4C. However, PDZRN3 itself has not previously been characterized. We have now evaluated the properties and functions of PDZRN3. The PDZRN3 gene was shown to be expressed in various human tissues including the heart, skeletal muscle and liver and its expression in mouse skeletal muscle was developmentally regulated. Both the differentiation of C2C12 mouse skeletal myoblasts into myotubes and injury-induced muscle regeneration in vivo were found to be accompanied by up-regulation of PDZRN3. The differentiation-associated increase in the expression of PDZRN3 in C2C12 cells follows that of myogenin and precedes that of myosin heavy chain. Depletion of PDZRN3 by RNA interference inhibited the formation of myotubes as well as the associated up-regulation of myosin heavy chain in C2C12 cells. Our data suggest that PDZRN3 plays an essential role in the differentiation of myoblasts into myotubes by acting either downstream or independently of myogenin.
Image Unavailable-10668-816

Anti-SEMCAP3 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10668-816)
Supplier: Bioss
Description: PDZRN3 contains a RING-finger motif in its N-terminal region, two PDZ domains in its central region and a consensus-binding motif for PDZ domains at its C-terminus. It was identified in silico as a homolog of the protein known as LNX1 or SEMCAP1, which possesses ubiquitin ligase activity and binds the membrane protein Semaphorin 4C. However, PDZRN3 itself has not previously been characterized. We have now evaluated the properties and functions of PDZRN3. The PDZRN3 gene was shown to be expressed in various human tissues including the heart, skeletal muscle and liver and its expression in mouse skeletal muscle was developmentally regulated. Both the differentiation of C2C12 mouse skeletal myoblasts into myotubes and injury-induced muscle regeneration in vivo were found to be accompanied by up-regulation of PDZRN3. The differentiation-associated increase in the expression of PDZRN3 in C2C12 cells follows that of myogenin and precedes that of myosin heavy chain. Depletion of PDZRN3 by RNA interference inhibited the formation of myotubes as well as the associated up-regulation of myosin heavy chain in C2C12 cells. Our data suggest that PDZRN3 plays an essential role in the differentiation of myoblasts into myotubes by acting either downstream or independently of myogenin.
Image Unavailable-76107-578

Anti-SEMCAP3 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76107-578)
Supplier: Bioss
Description: PDZRN3 contains a RING-finger motif in its N-terminal region, two PDZ domains in its central region and a consensus-binding motif for PDZ domains at its C-terminus. It was identified in silico as a homolog of the protein known as LNX1 or SEMCAP1, which possesses ubiquitin ligase activity and binds the membrane protein Semaphorin 4C. However, PDZRN3 itself has not previously been characterized. We have now evaluated the properties and functions of PDZRN3. The PDZRN3 gene was shown to be expressed in various human tissues including the heart, skeletal muscle and liver and its expression in mouse skeletal muscle was developmentally regulated. Both the differentiation of C2C12 mouse skeletal myoblasts into myotubes and injury-induced muscle regeneration <i>in vivo</i> were found to be accompanied by up-regulation of PDZRN3. The differentiation-associated increase in the expression of PDZRN3 in C2C12 cells follows that of myogenin and precedes that of myosin heavy chain. Depletion of PDZRN3 by RNA interference inhibited the formation of myotubes as well as the associated up-regulation of myosin heavy chain in C2C12 cells. Our data suggest that PDZRN3 plays an essential role in the differentiation of myoblasts into myotubes by acting either downstream or independently of myogenin.
Image Unavailable-10668-800

Anti-SEMCAP3 Rabbit Polyclonal Antibody

Catalog Number: (10668-800)
Supplier: Bioss
Description: PDZRN3 contains a RING-finger motif in its N-terminal region, two PDZ domains in its central region and a consensus-binding motif for PDZ domains at its C-terminus. It was identified in silico as a homolog of the protein known as LNX1 or SEMCAP1, which possesses ubiquitin ligase activity and binds the membrane protein Semaphorin 4C. However, PDZRN3 itself has not previously been characterized. We have now evaluated the properties and functions of PDZRN3. The PDZRN3 gene was shown to be expressed in various human tissues including the heart, skeletal muscle and liver and its expression in mouse skeletal muscle was developmentally regulated. Both the differentiation of C2C12 mouse skeletal myoblasts into myotubes and injury-induced muscle regeneration in vivo were found to be accompanied by up-regulation of PDZRN3. The differentiation-associated increase in the expression of PDZRN3 in C2C12 cells follows that of myogenin and precedes that of myosin heavy chain. Depletion of PDZRN3 by RNA interference inhibited the formation of myotubes as well as the associated up-regulation of myosin heavy chain in C2C12 cells. Our data suggest that PDZRN3 plays an essential role in the differentiation of myoblasts into myotubes by acting either downstream or independently of myogenin.
Image Unavailable-10668-814

Anti-SEMCAP3 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10668-814)
Supplier: Bioss
Description: PDZRN3 contains a RING-finger motif in its N-terminal region, two PDZ domains in its central region and a consensus-binding motif for PDZ domains at its C-terminus. It was identified in silico as a homolog of the protein known as LNX1 or SEMCAP1, which possesses ubiquitin ligase activity and binds the membrane protein Semaphorin 4C. However, PDZRN3 itself has not previously been characterized. We have now evaluated the properties and functions of PDZRN3. The PDZRN3 gene was shown to be expressed in various human tissues including the heart, skeletal muscle and liver and its expression in mouse skeletal muscle was developmentally regulated. Both the differentiation of C2C12 mouse skeletal myoblasts into myotubes and injury-induced muscle regeneration in vivo were found to be accompanied by up-regulation of PDZRN3. The differentiation-associated increase in the expression of PDZRN3 in C2C12 cells follows that of myogenin and precedes that of myosin heavy chain. Depletion of PDZRN3 by RNA interference inhibited the formation of myotubes as well as the associated up-regulation of myosin heavy chain in C2C12 cells. Our data suggest that PDZRN3 plays an essential role in the differentiation of myoblasts into myotubes by acting either downstream or independently of myogenin.
Product Image-470148-930

Porcelain Crucible Covers

Supplier: SILICO & CHEMICO PORCELAIN SE
Description: These glazed porcelain covers fit high and low form crucibles.

Image Unavailable-ICI-TA-10085

1" ID X 3/16" WALL PLATINUM CURED SILICO

Catalog Number: (ICI-TA-10085)
Supplier: AVANTOR FLUID HANDLING, LLC
Description: 1" ID X 3/16" WALL PLATINUM CURED SILICO

New Product


Image Unavailable-MSPP-29660

MAT RESEALABLE PFTE/SILICO SQ 96WELL PK5

Catalog Number: (MSPP-29660)
Supplier: ANALYTICAL SALES & SERVICE MS
Description: MAT RESEALABLE PFTE/SILICO SQ 96WELL PK5
Image Unavailable-470149-556

EVAP DISH SIZE 3 150 ML

Catalog Number: (470149-556)
Supplier: SILICO & CHEMICO PORCELAIN SE
Description: EVAP DISH SIZE 3 150 ML
Image Unavailable-470149-038

FUNNEL BUCHNER SZ 1 - 63MM

Catalog Number: (470149-038)
Supplier: SILICO & CHEMICO PORCELAIN SE
Description: FUNNEL BUCHNER SZ 1 - 63MM
Image Unavailable-CA10799-104

CRUCIBLES TALL FORM PORCELAIN G-10

Catalog Number: (CA10799-104)
Supplier: SILICO & CHEMICO PORCELAIN SE
Description: CRUCIBLES TALL FORM PORCELAIN G-10
Image Unavailable-CA10799-106

CRUCIBLES TALL FORM PORCELAIN G-15

Catalog Number: (CA10799-106)
Supplier: SILICO & CHEMICO PORCELAIN SE
Description: CRUCIBLES TALL FORM PORCELAIN G-15
Image Unavailable-CA10799-108

CRUCIBLES TALL FORM GLAZED PORCELAIN

Catalog Number: (CA10799-108)
Supplier: SILICO & CHEMICO PORCELAIN SE
Description: CRUCIBLES TALL FORM GLAZED PORCELAIN
Image Unavailable-CA77532-246

WarmStart® RTx Reverse Transcriptase, Glycerol-free

Catalog Number: (CA77532-246)
Supplier: New England Biolabs (NEB)
Description: WarmStart RTx Reverse Transcriptase (Glycerol-free) is formulated without glycerol to support lyophilization, incorporation into microfluidic devices, and enable quick adoption into automation workflows.

New Product


Image Unavailable-CA77532-244

WarmStart® Bst 2.0 DNA Polymerase, Glycerol-free

Catalog Number: (CA77532-244)
Supplier: New England Biolabs (NEB)
Description: Bst 2.0 WarmStart DNA polymerase (glycerol-free) is formulated without glycerol to support lyophilization, incorporation into microfluidic devices, and enable quick adoption into automation workflows.

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