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Description: The Sklar Blue™ Pederson Vaginal Speculum is used for electrocsurgical gynecological procedures, such as LEEP.
Catalog Number: 10184-392
Supplier: Sklar


Description: DAB2 is a protein of 770 amino acid residues with a predicted molecular weight of 85.5kDa. This gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta). Human DAB2 has an overall 83% identify with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain (PID), and contains multiple SH3 binding motifs. Chromosomal localization by FISH showed that the DAB2 gene is located on 5p13. The expression of DAB2 is down-regulated or absent in all the carcinoma cell lines examined, including prostate and ovarian carcinoma cell lines. The N-terminal domain of DAB2 interacts with Dishevelled-3 (Dvl-3), a signaling mediator of the Wnt pathway. Ectopic expression of DAB2 attenuates canonical Wnt/catenin-mediated signaling, including accumulation of catenin and cyclin D1 induction. DAB2 suppresses both protein kinase C and peptide growth factor-elicited signal pathways via the Ras-mitogen-activated protein kinase pathway. The proline-rich domain of DAB2 also interacts with proteins containing SH3 domain, such as Src and Fgr. The binding of DAB2 to c-Src resultes in the inactivation of c-Src. All data suggest that DAB2 is a potent tumor suppressor in many cancer types.
Catalog Number: 10085-642
Supplier: Proteintech


Description: Sklar Black™ Kogan laser endocervical speculum is a gynecological instrument used for viewing the distal endocervical canal.
Catalog Number: 10199-180
Supplier: Sklar


Description: Sklar's® Barraquer Wire Speculum is an ophthalmic instrument used in retracting the eye lid and holding it open during surgery.
Catalog Number: 10194-642
Supplier: Sklar


Description: The Kratz-Barraquer Wire Speculum is an ophthalmic instrument used to retain the eyelids open, often during cataract or phacoemulsification procedures
Catalog Number: 10197-918
Supplier: Sklar


Description: The Sklar Black™ Graves Wide-View Vaginal Speculum is used for laser gynecological procedures
Catalog Number: 10184-274
Supplier: Sklar


Description: Sklar Black™ Graves Vaginal Speculum is used for laser gynecological procedures.
Catalog Number: 10184-230
Supplier: Sklar


Description: Sklar Blue™ Kogan endocervical speculums are constructed of stainless steel and feature a non conductive coating.
Catalog Number: 10184-490
Supplier: Sklar


Description: The Sklar Blue™ Graves OB-View Vaginal Speculum is used for electrocsurgical gynecological procedures, such as LEEP.
Catalog Number: 10184-316
Supplier: Sklar


Description: The Sklar Black™ freeway-graves vaginal speculum is used for laser gynecological procedures.
Catalog Number: 10197-226
Supplier: Sklar


Description: The Sklar Steiner-Auvard Weighted Vaginal Speculum is a single end vaginal speculum commonly used in OB/GYN procedures, such as vaginal hysterectomy or dilation and curettage.
Catalog Number: 10197-198
Supplier: Sklar


Description: Toynbee Ear Specula are chrome plated.
Catalog Number: 10198-432
Supplier: Sklar


Description: Sklar's® Plain Wire Eye Speculum is an opthalmic instrument used to separate and hold open the eyelids
Catalog Number: 10194-648
Supplier: Sklar


Description: These glove features a premium 18 mil latex canners glove.
Catalog Number: 80081-420
Supplier: MCR Safety


Description: The Sklar Black™ Auvard Weighted Vaginal Speculum is a single end vaginal speculum commonly used in laser OB/GYN procedures.
Catalog Number: 10184-292
Supplier: Sklar


Description: Sklar Black™ Auvard Weighted Vaginal Speculum is a single-end vaginal speculum commonly used in laser OB/GYN procedures
Catalog Number: 10184-284
Supplier: Sklar


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