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Product Image-10782-366

Anti-APP Rabbit Polyclonal Antibody

Description: FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. FUNCTION: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. Rat and mouse beta-amyloid peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation (By similarity). FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. SUBUNIT: Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1, Numb and Dab1. Binding to Dab1 inhibits its serine phosphorylation. Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains. Associates with microtubules in the presence of ATP and in a kinesin-dependent manner. Interacts, through a C-terminal domain, with GNAO1. Amyloid beta-42 binds CHRNA7 in hippocampal neurons. Beta-amyloid associates with HADH2. TISSUE SPECIFICITY: different isoforms in different tissues: kidney. brain. liver. hippocampus, substania nigra pars compacta and cerebellum. In the cerebellum, all the isoforms are abundantly expressed in Purkinje cells.
Catalog Number: 10782-366
Supplier: Biosensis
Image Unavailable-89351-244

Anti-BRCA1 Mouse Monoclonal Antibody [clone: MS13]

Description: BRCA1 (breast and ovarian cancer susceptibility protein 1) is a RING finger protein containing a BRCT domain. BRCA1 exists as a heterodimer with 22 possible isoforms. The full length protein has a reported molecular weight of 208 kD. BRCA1 localizes to the mitotic spindle microtubules, centriole walls, pericentriolar fibers at centrosomes. Unphosphorylated BRCA1 localizes on chromosomes from metaphase through telophase; phosphorylated BRCA1 resides in inner chromosomal structure, centrosome, cleavage furrow during prophase through telophase, and relocalizes to the perinuclear region when cells are subjected to IR or UV radiation in S phase. BRCA1 acts as a tumor suppressor and can function as a secreted growth inhibitory protein, participate in transcription coupled repair of oxidative DNA damage, X-chromosome inactivation, and can function as a E3 ubiquitin ligase. BRCA1 can be transcriptionally downregulated by Ets-2, Brg-1, and Hmga-1. BRCA1 can be modified by glycosylation, ubiquitination and phosphorylation by CDK4, ATM/ATR, cdk2, and hChk2. The BRCA1 protein has been reported to interact with RNA polymerase II holoenzyme and BARD1. BRCA1 contains at least two nuclear localization signals and is proposed to be a tumor suppressor protein. It is a serine phosphoprotein that undergoes hyperphosphorylation during late G1 and S phases of the cell cycle and is transiently dephosphorylated early after M phase. BRCA1 protein alters in a qualitative and quantitative manner during cell cycle progression. The amount of BRCA1 protein is highest during S phase and remains elevated toward G2 / M, before it declines in early G1 phase. Inherited loss of BRCA1 function confers an increased susceptibility for both breast and ovarian cancer.
Catalog Number: 89351-244
Supplier: Genetex
Image Unavailable-TCT2184-1G

Tris(dibenzylideneacetone)dipalladium(0) ≥75.0% (by titrimetric analysis)

Description: CAS Number: 51364-51-3
Molecular Formula: C51H42O3Pd2
Molecular Weight: 915.73
Purity/Analysis Method: >75.0% (T)
Form: Crystal
Color: Deep Yellow Red
Melting point (°C): 155
Catalog Number: TCT2184-1G
Supplier: TCI America

SDS Certificates


Product Image-100495-634

Gilder Standard Square Mesh Grids, Gilder Grids

Description: In Copper (Cu), Nickel (Ni), Gold (Au), Copper/Palladium (Cu/Pd=CP), Molybdenum (Mo).
Catalog Number: 100495-634
Supplier: Electron Microscopy Sciences

Minority or Woman-Owned Business Enterprise


Product Image-100492-090

Precious Wires, Electron Microscopy Sciences

Description: Aluminum Wire: Purity 99.99
Catalog Number: 100492-090
Supplier: Electron Microscopy Sciences

Minority or Woman-Owned Business Enterprise


Product Image-10782-368

Anti-APP Rabbit Polyclonal Antibody

Description: FUNCTION: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1/Tip60 and inhibit Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. May be involved in copper homeostasis/oxidative stress through copper ion reduction. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. FUNCTION: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. Rat and mouse beta-amyloid peptides bind only weakly transient metals and have little reducing activity due to substitutions of transient metal chelating residues. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation (By similarity). FUNCTION: The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. SUBUNIT: Binds, via its C-terminus, to the PID domain of several cytoplasmic proteins, including APBB family members, the APBA family, MAPK8IP1, SHC1, Numb and Dab1. Binding to Dab1 inhibits its serine phosphorylation. Also interacts with GPCR-like protein BPP, FPRL1, APPBP1, IB1, KNS2 (via its TPR domains), APPBP2 (via BaSS) and DDB1. In vitro, it binds MAPT via the MT-binding domains. Associates with microtubules in the presence of ATP and in a kinesin-dependent manner. Interacts, through a C-terminal domain, with GNAO1. Amyloid beta-42 binds CHRNA7 in hippocampal neurons. Beta-amyloid associates with HADH2. TISSUE SPECIFICITY: different isoforms in different tissues: kidney. brain. liver. hippocampus, substania nigra pars compacta and cerebellum. In the cerebellum, all the isoforms are abundantly expressed in Purkinje cells.
Catalog Number: 10782-368
Supplier: Biosensis
Product Image-100494-984

BSE Reference Standards, Electron Microscopy Sciences

Description: When equipped with a back-scattered electron detector, an electron microscope has the capability to produce images in which the contrast is controlled by differences in atomic number across the specimen
Catalog Number: 100494-984
Supplier: Electron Microscopy Sciences

Minority or Woman-Owned Business Enterprise


Image Unavailable-CAAA44446-04

Di-µ-bromobis(tri-tert-butylphosphine)dipalladium(I)

Description: Applications: Coupling reactions. Will activate aryl chloride and sterically hindered or electron rich aryl/vinyl bromides and iodides. Especially active in difficult aminations
Catalog Number: CAAA44446-04
Supplier: Thermo Scientific Chemicals

Certificates


Product Image-100495-200

MAC X-ray Microanalysis Individual Standards, Grains, Electron Microscopy Sciences

Description: All MAC X-ray Microanalysis standards are suitable for electron-beam energy dispersive or wavelength dispersive X-ray microanalysis systems.
Catalog Number: 100495-200
Supplier: Electron Microscopy Sciences

Minority or Woman-Owned Business Enterprise


Product Image-100495-098

MAC X-Ray Microanalysis Individual Standards, Micro-Analysis Consultants

Description: All MAC X-ray Microanalysis standards are suitable for electron-beam energy dispersive or wavelength dispersive X-ray microanalysis systems.
Catalog Number: 100495-098
Supplier: Electron Microscopy Sciences

Minority or Woman-Owned Business Enterprise


Image Unavailable-CAAA11042-09

Ammonium hexachloropalladate(IV) (29% Pd) ≥99.9% (metals basis) Pd 29%

Description: MDL: MFCD00015959
Catalog Number: CAAA11042-09
Supplier: Thermo Scientific Chemicals

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Product Image-89419-992

Palladium standard solution, 10,000 mg/L Pd in 5% hydrochloric acid standard for ICP

Description: NIPSNAP3B peptide is used for blocking the activity of NIPSNAP3B antibody.
Catalog Number: 89419-992
Supplier: Prosci
Product Image-89419-398

Palladium standard solution, 1,000 mg/L Pd in 10% hydrochloric acid standard for ICP

Description: NogoA peptide is used for blocking the activity of NogoA antibody.
Catalog Number: 89419-398
Supplier: Prosci
Product Image-89419-716

Palladium standard solution, 10,000 mg/L Pd in dil. nitric acid standard for ICP

Description: NPTX2 peptide is used for blocking the activity of NPTX2 antibody.
Catalog Number: 89419-716
Supplier: Prosci
Product Image-CA97013-366

Lumina™ Palladium (Pd) Hollow Cathode Lamp, PerkinElmer

Description: Series N30501XX Lumina™ 50 mm (2") diameter single-element lamps are designed to be used with the PinAAcle™ and AAnalyst™ Atomic Absorption spectrometer series of instruments.
Catalog Number: CA97013-366
Supplier: PerkinElmer
Product Image-CAJT0540-5

Aluminium oxide neutral, powder, BAKER ANALYZED®, J.T.Baker®

Description: Aluminium oxide neutral, powder, BAKER ANALYZED®, J.T.Baker®
Catalog Number: CAJT0540-5
Supplier: VWR International

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