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Image Unavailable-CA76634-490

Anti-GCDFP-15 Mouse Monoclonal Antibody [clone: DBM15.52]

Catalog Number: (CA76634-490)
Supplier: Diagnostic Biosystems
Description: It recognizes a protein of 15kDa, identified as Gross cystic disease fluid protein 15 (GCDFP-15). It is a major protein component of benign breast gross cysts. It is a known marker of breast cancer, as it is found in approximately 50% of all breast cancer specimens. GCDFP-15, also known as PIP, for prolactin inducible protein, is a prolactin and androgen controlled protein. This antibody is useful in the identification of metastatic breast carcinoma, or fluid analysis.
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Anti-Smad4 Rabbit Polyclonal Antibody

Supplier: Diagnostic Biosystems
Description: SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. Alterations in the SMAD4 gene was primarily discovered in pancreatic cancer (duct adenocarcinoma) but occur in a variety of cancers such as colorectal cancer, gastric cancer, prostate cancer, melanomas, head and neck cancers and many others, though with higher frequencies in gastrointestinal tract cancers. Loss of SMAD4 expression in tumors has also been shown to affect cancer progression and therapy, such as reduced response to adjuvant chemotherapy.

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Anti-Smad4 Rabbit Polyclonal Antibody

Catalog Number: (CA76634-676)
Supplier: Diagnostic Biosystems
Description: SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. Alterations in the SMAD4 gene was primarily discovered in pancreatic cancer (duct adenocarcinoma) but occur in a variety of cancers such as colorectal cancer, gastric cancer, prostate cancer, melanomas, head and neck cancers and many others, though with higher frequencies in gastrointestinal tract cancers. Loss of SMAD4 expression in tumors has also been shown to affect cancer progression and therapy, such as reduced response to adjuvant chemotherapy.
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Anti-P53 Protein Mouse Monoclonal Antibody [clone: DO7]

Supplier: Diagnostic Biosystems
Description: This antibody reacts with wild as well as mutant types of P53 protein. It recognizes an epitope in the N-terminus of P53 protein, known to reside between amino acids 35 to 45. This antibody can be demonstrated in 22 to 76% of the colon, stomach, bladder, breast, lung and testes cancers.

Image Unavailable-CA76634-504

Anti-CA 125 Mouse Monoclonal Antibody [clone: OV185:1]

Catalog Number: (CA76634-504)
Supplier: Diagnostic Biosystems
Description: This antibody reacts specifically with CA 125 ovarian cancer antigen. Several studies have shown that CA 125 is a useful tumor marker for ovarian epithelial malignancies. However, CA 125 has been described in other neoplasms such as seminal vesicle and anaplastic lymphomas.
Image Unavailable-CA76634-274

Anti-P53 Mouse Monoclonal Antibody [clone: DO7]

Catalog Number: (CA76634-274)
Supplier: Diagnostic Biosystems
Description: This antibody reacts with wild as well as mutant types of P53 protein. It recognizes an epitope in the N-terminus of p53 protein, known to reside between amino acids 35 to 45. This antibody can be demonstrated in 22 to 76% of the colon, stomach, bladder, breast, lung and testes cancers.
Image Unavailable-CA76633-306

Anti-CA125 Mouse Monoclonal Antibody [clone: OV185:1]

Supplier: Diagnostic Biosystems
Description: This antibody reacts specifically with CA 125 ovarian cancer antigen. Several studies have shown that CA 125 is a useful tumor marker for ovarian epithelial malignancies. However, CA 125 has been described in other neoplasms such as seminal vesicle and anaplastic lymphomas.

Image Unavailable-CA76634-012

Anti-GCDFP-15 Mouse Monoclonal Antibody [clone: DBM15.52]

Supplier: Diagnostic Biosystems
Description: It recognizes a protein of 15 kDa, identified as Gross cystic disease fluid protein 15 (GCDFP-15). It is a major protein component of benign breast gross cysts. It is a known marker of breast cancer, as it is found in approximately 50% of all breast cancer specimens. GCDFP-15, also known as PIP, for prolactin inducible protein, is a prolactin and androgen controlled protein. This antibody is useful in the identification of metastatic breast carcinoma, or fluid analysis.

Image Unavailable-CA76634-554

Anti-PD-L1 Mouse Monoclonal Antibody [clone: 405-9A11]

Catalog Number: (CA76634-554)
Supplier: Diagnostic Biosystems
Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.
Image Unavailable-CA76634-164

Anti-PD-L1 Mouse Monoclonal Antibody [clone: 405-9A11]

Supplier: Diagnostic Biosystems
Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.

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Anti-PD-1 Mouse Monoclonal Antibody [clone: EH33]

Supplier: Diagnostic Biosystems
Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.

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Anti-Thymidine Phosphorylase Mouse Monoclonal Antibody [clone: P-GF.44C]

Supplier: Diagnostic Biosystems
Description: This antibody is specific to a 55 kDa protein known as platelet-derived endothelial growth factor (PD-ECGF), or thymidine phosphorylase (TP). High levels of TP/PD-ECGF are observed in cancer patients. High intracellular levels of TP/PD-ECGF are associated with increased sensitivity to fluoropyrimidine chemotherapeutic agents.

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Anti-Tag-72 Mouse Monoclonal Antibody [clone: B72.3]

Supplier: Diagnostic Biosystems
Description: This antibody is specific to an oncofetal antigen of >1,000 kDa known as tumor associated glycoprotein (TAG-72) or CA 72-4. This antibody defines the mucin carried sialylated-Tn antigen. This antibody stains the majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary and non-small cell lung cancer.

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Anti-PD-1 Mouse Monoclonal Antibody [clone: EH33]

Catalog Number: (CA76634-556)
Supplier: Diagnostic Biosystems
Description: The programmed death receptor 1 (PD-1) protein is a cell-surface receptor on certain lymphocytes that, with its ligand programmed death ligand 1 (PD-L1), helps to down-regulate immune responses. Many cancer types express PD-L1 and evade immune recognition via the PD-1/PD-L1 interaction. Precision therapies targeting the PD-1/PD-L1 pathway have the potential to improve response and thereby offer a novel treatment avenue to some patients with cancer.
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Anti-PMS2 Mouse Monoclonal Antibody [clone: A16-4]

Catalog Number: (CA76634-444)
Supplier: Diagnostic Biosystems
Description: Postmeiotic segregation increased 2 or PMS2 was originally discovered in S. cerevisiae and is part of the mismatch repair system. It resides on 7p22.2 and its gene product partner with MLH1 to help detect mismatches in DNA. Mutations in PMS2 have been reported in about two percent of families with Lynch syndrome (hereditary nonpolyposis colorectal cancer).
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Anti-HER2/neu (c-erb-2) Rabbit Polyclonal Antibody

Supplier: Diagnostic Biosystems
Description: This antibody recognizes a c-erbB-2 protein, which is a receptor tyrosine kinase of the c-erbB family. It is closely related in structure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a subset of breast and other adenocarcinomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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