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Product Image-76262-746

Anti-Ngp Rabbit Polyclonal Antibody

Catalog Number: (76262-746)
Supplier: Rockland Immunochemical
Description: This antibody is designed, produced, and validated as part of a collaboration between Rockland and the National Cancer Institute (NCI). A proteomic study in 2011 determined a direct correlation between NGP mRNA levels and myeloid-derived suppressor cells. Specifically cathepsin B, a catalytic mechanism and potentially biomarker in a variety of cancers and amyloid plaque development, was inhibited by NGP. The significance of NGP as a negative regulator of tumor metastasis makes this antibody ideal for investigators involved in cancer research, as well as Alzheimer’s research.
Image Unavailable-76118-046

Anti-Hepsin Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76118-046)
Supplier: Bioss
Description: This gene encodes a type II transmembrane serine protease. The encoded protein has an extracellular region that consists of two domains, a catalytic serine protease domain and a non-catalytic scavenger receptor cysteine-rich domain. This protein may be involved in diverse cellular functions including blood coagulation, maintenance of cell morphology and the growth and progression of certain cancers, particularly prostate cancer. Alternative splicing results in multiple transcript variants.
Image Unavailable-10472-590

Anti-DUSP26 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10472-590)
Supplier: Bioss
Description: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).Tissue specificity:Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
Image Unavailable-10472-596

Anti-DUSP26 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10472-596)
Supplier: Bioss
Description: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).Tissue specificity:Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
Image Unavailable-10472-592

Anti-DUSP26 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10472-592)
Supplier: Bioss
Description: Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).Tissue specificity:Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma) and in anaplatic thyroid cancer.
Product Image-10749-018

Anti-KLF17 Rabbit Polyclonal Antibody

Catalog Number: (10749-018)
Supplier: Prosci
Description: KLF17, also known as ZNF393, is a member of the Sp/KLF family of transcription factors. KLF17 binds to the promoter and negatively regulates the transcription of Id-1, a key metastasis regulator in breast cancer. Suppression of KLF17 promotes breast cancer cell invasion and epithelial-mesenchymal transition. Down-regulated KLF17 expression is also associated tumor invasion and poor prognosis in hepatocellular carcinoma, suggesting that the level of KLF17 expression can serve as a prognostic indicator.
Image Unavailable-10340-620

Anti-ZNF217 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10340-620)
Supplier: Bioss
Description: ZNF217 (Zinc-finger protein 217) is a Kruppel-like zinc-finger protein which functions as a transcriptional repressor protein and forms a complex with a number of proteins including CoREST, BHC110/LSD1, HDAC2 and CtBP1. ZNF217 has been shown to repress E-cadherin promoter activity. ZNF217 is overexpressed in a number of cancers including breast and ovarian. ZNF217 and its associated proteins have been implicated in a novel pathway that is involved in cancer progression.
Product Image-10749-022

Anti-PPM1D Rabbit Polyclonal Antibody

Catalog Number: (10749-022)
Supplier: Prosci
Description: Wild-type p53 induced phosphatase 1 (WIP1) / protein phosphatase magnesium-dependent 1 delta (PPM1D), a protein identified in the p53 DNA response pathway, is a member of the PP2C family of serine/threonine protein phosphatases which selectively inactivates p38 MAPK and dephosphorylates the ATM/ATR targets, Chk1 and p53. Studies have shown that it is overexpressed in human cancers and is involved in the regulation of multiple DNA damage signaling pathways. PPM1D deletion results in a reduction of T and B cell function and compromised cell division, rendering cells resistant to becoming cancerous and slowing tumor development.
Image Unavailable-52197-076

Accessories for Multi-Sample Osmometer, Model 3900, Advanced Instruments

Supplier: Advanced Instruments
Description: 0.2mL. For use with osmometers.

Certificates

Product Image-16060-044

Nalgene® Diagnostic Bottles, Opaque Amber, HDPE, without Closures, Bulk Pack, Thermo Scientific

Supplier: Thermo Fisher Scientific
Description: Nalgene opaque amber high density polyethylene diagnostic bottles are used in test kits and many small-volume applications.

Product Image-10049-244

25(OH) Vitamin D ELISA Kit, Enzo Life Sciences

Catalog Number: (10049-244)
Supplier: Enzo Life Sciences
Description: Rapid, easy-to-use ELISA kit to quantify 25(OH) Vitamin D for bone metabolism, nutrition, endocrinology, immunity and cancer.
Image Unavailable-75791-914

Human Recombinant Cadherin-1 (from Cells)

Catalog Number: (75791-914)
Supplier: Prosci
Description: E-Cadherin is a classical member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells, and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. Also, E-Cadherin has a potent invasive suppressor role and it is a ligand for integrin alpha-E/beta-7.
Image Unavailable-10477-496

Anti-CCDC36 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10477-496)
Supplier: Bioss
Description: CCDC36 , also known as CT74 (cancer/testis antigen 74), is a 584 amino acid protein that contains coiled-coil domains and is expressed as three alternatively spliced isoforms. The gene encoding CCDC36 maps to human chromosome 3, which houses over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
Image Unavailable-10386-570

Anti-P53 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10386-570)
Supplier: Bioss
Description: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].
Image Unavailable-76098-994

Anti-C3orf19 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76098-994)
Supplier: Bioss
Description: Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. The C3orf19 gene product has been provisionally designated C3orf19 pending further characterization.
Image Unavailable-76078-496

Anti-ELAC2 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76078-496)
Supplier: Bioss
Description: ELAC2 is a zinc phosphodiesterase which displays some tRNA 3' processing endonuclease activity. It is thought to be involved in tRNA maturation, acting by removing a 3' trailer from precursor tRNA. ELAC2 also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. A number of allelic variants have been investigated in hereditary prostate cancer.
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