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Human Recombinant PI3K (p110 alpha(H1047R, His tag)/p85 alpha, His tag), Active (from Baculovirus-Insect Cells)

Supplier: Sino Biological
Description: Recombinant full length human p110 alpha (H1047R) and p85 alphasubunits were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins.

New Product

Image Unavailable-H-6935.0005BA

(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P

Supplier: Bachem Americas
Description: Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.

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Anti-TP53 Mouse Monoclonal Antibody (CF488A) [clone: TRP/816]

Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Product Image-470003-468

Celestron NexStar 130 SLT Reflector Telescope

Catalog Number: (470003-468)
Supplier: Celestron International
Description: The Celestron NexStar 130 SLT Reflector Telescope lets you view the details of the lunar surface, the rings of Saturn, the polar ice caps on Mars, the cloud belts on Jupiter, or a number of the Messier objects.
Product Image-76262-724

Anti-TP53 Rabbit Polyclonal Antibody

Catalog Number: (76262-724)
Supplier: Rockland Immunochemical
Description: TP53 (tumor suppressor gene p53) is one of the most well-studied genes that suppresses tumor formation and renders protection against DNA damage by inducing cell cycle arrest, DNA repair, or apoptosis. TP53 signaling is triggered through numerous cellular events ranging from DNA damage to hypoxia, stress and a plethora of other causes. Upon activation, p53 acts as zinc-containing transcriptional regulator and initiates a cascade of events that determines the cellular outcome including cell cycle arrest, apoptosis, senescence, DNA repair, development, differentiation and tissue homeostasis. Cell cycle arrest is induced by p53 via trans-activating genes such as p21 (CDK-inhibitor 1, cyclin dependent kinase) and others. Interestingly, p53 itself is capable of triggering cellular responses (survival or induced cell death) as well. Mutations or deletions in the TP53 gene are present in nearly 50% of human cancers, and primarily results in impaired tumor suppressor function. Anti-p53 (ac Lys292) antibody is ideal for researchers interested in developmental biology, cell growth and cancer research.
Product Image-30624-010

Dura-Mag™ Magnetic Stirrers, 5-position, Chemglass

Supplier: Chemglass
Description: The five position magnetic stirrer is a rugged design for 24/7 laboratory or production applications. It is ideal for CO<sub>2 </sub>incubators with a maximum capacity of five 1000 ml spinner vessels.

Small Business Enterprise

Product Image-14226-000

SGE BPX70 GC Capillary Columns

Supplier: Trajan Scientific and Medical
Description: The SGE BPX70 GC capillary column provides a great polar option for GC analyzes. Recommended for fatty acid methyl esters (FAMEs), carbohydrates, pharmaceuticals, GC-MS applications.

Product Image-30623-116

6-Well and 24-Well Cell Culture Plate, Glass Bottom, Chemglass

Supplier: Chemglass
Description: These glass bottom culture plates are used in confocal microscope, differential interference contrast microscope, polarized light microscope and phase contrast microscope for cell observation.

Small Business Enterprise

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Hypersil GOLD™ PEI HILIC HPLC Column

Catalog Number: (76477-176)
Supplier: Thermo Scientific
Description: Highly polar and hydrophilic analytes that are difficult to analyze with conventional C18 columns can be retained with Thermo Scientific™ Hypersil GOLD™ PEI HILIC LC columns for hydrophilic interaction chromatography.
Product Image-10500-172

GsBP®-Tubing PEG Deactivated GC Column, GS-Tek

Supplier: General Separation Technologies, Inc.
Description: GC tubing.

Product Image-10058-580

Drilled Uniliner® Inlet Liner with Hole near Bottom and Top Taper for Agilent GCs Equipped with Split/Splitless Inlets, Restek

Catalog Number: (10058-580)
Supplier: Restek
Description: Use of these liners helps ensure an inert GC flow path for higher sensitivity, accuracy, and reproducibility.
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Anti-TP53 Mouse Monoclonal Antibody (CF405S) [clone: BP53-12 DO-7]

Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 under denaturing and non-denaturing conditions. Its epitope maps within the N-terminus (aa 20-25) of p53 oncoprotein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

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Bond Elut SCX Plates

Catalog Number: (AG7540701C)
Supplier: AGILENT TECHNOLOGIES, INC (CSD)
Description: Bond Elut SCX is a strong cation-exchanger with a very low pKa, while the benzene ring in the functional group increases the potential for non-polar interactions.
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Anti-LOC51057 Rabbit Polyclonal Antibody

Catalog Number: (89266-640)
Supplier: Genetex
Description: Rabbit polyclonal antibody to LOC51057 (N-terminal)
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Anti-TP53 Mouse Monoclonal Antibody [clone: TRP/817]

Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.

Product Image-RK14052

Rtx®-225 Columns (Fused Silica), Restek

Supplier: Restek
Description: The cyanopropyl-containing Rtx®-225 phase is slightly less polar than bonded polyethylene glycol (PEG) phases, but it can be used for many of the same applications.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
You must log in to order restricted items. We request that you provide the required business documentation to purchase this product for the first time.

To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
  • Government issued document with your organization's Resale Tax ID Number
  • Any other Government ID that includes the business name and address


VWR will not lift restrictions for residential shipping addresses.

-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
This product has been blocked by your organization. Please contact your purchasing department for more information.
The original product is no longer available. The replacement shown is available.
This product is currently unavailable but limited stock may be available in our extended warehouse network. Please call 1-800-932-5000 and a VWR Customer Service Representative will help you.
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