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Product Image-10068-984

Anti-MAPT Rabbit Polyclonal Antibody

Catalog Number: (10068-984)
Supplier: Prosci
Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Image Unavailable-10671-614

Anti-DVL2 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10671-614)
Supplier: Bioss
Description: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).
Product Image-10068-988

Anti-MAPT Rabbit Polyclonal Antibody

Catalog Number: (10068-988)
Supplier: Prosci
Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Product Image-10070-238

Anti-MAPT Rabbit Polyclonal Antibody

Catalog Number: (10070-238)
Supplier: Prosci
Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Image Unavailable-77561-430

Human Recombinant PI3K (p110 alpha (E545K, GST tag)/p85 alpha, GST tag), Active (from Baculovirus-Insect Cells)

Supplier: Sino Biological
Description: Recombinant full length human p110alpha (E545K) mutant subunit and full length human p85alpha wild-type subunit were co-expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins.

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Image Unavailable-77561-432

Human Recombinant PI3K (p110 alpha (E545K, His tag)/p85 alpha, His tag), Active (from Baculovirus-Insect Cells)

Supplier: Sino Biological
Description: Recombinant full length human p110 alpha (E545K) mutant subunit and human p85 alpha wild-type subunit were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins.

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Image Unavailable-10423-528

Anti-ARHGAP24 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10423-528)
Supplier: Bioss
Description: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
Image Unavailable-76078-078

Anti-Tau protein Ser214 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76078-078)
Supplier: Bioss
Description: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Product Image-10666-322

Anti-DVL2 Rabbit Polyclonal Antibody

Catalog Number: (10666-322)
Supplier: Bioss
Description: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity).
Product Image-10101-222

Anti-CLCN3 Rabbit Polyclonal Antibody

Catalog Number: (10101-222)
Supplier: Prosci
Description: CLCN3 plays an important role in the cell proliferation of vascular smooth muscle cells. The PDZ-binding isoform of CLCN3 resides in the Golgi where it co-localizes with a small amount of CFTR (cystic fibrosis transmembrane conductance regulator).
Image Unavailable-75980-822

Anti-TP53 Mouse Monoclonal Antibody (CF647) [clone: Clone PAb122]

Supplier: Biotium
Description: PAb122 binds to the C-terminus (aa370-378) of both wild type and mutated p53. When microinjected into nuclei, PAb122 blocked re-entry into the S-phase of the cell cycle. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. p53 Binds to a DNA consensus sequence, the p53 response element, and it regulates normal cell growth cycle events by activating transcription of genes, involved either in progression through the cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. p53 Is the most commonly mutated gene in spontaneously occurring human cancers. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Image Unavailable-75909-534

Anti-CDw60 Mouse Monoclonal Antibody [clone: UM4D4]

Catalog Number: (75909-534)
Supplier: Biotium
Description: This MAb reacts with 9-O-acetylated disialosyl group linked to the glycoprotein CD60w. CDw60 is a carbohydrate antigen present on gangliosides, platelets and a subset of CD4 , CD8 peripheral T-cells, but not on B-cells, monocytes or granulocytes. CDw60 is involved in the co-stimulation of T-cells.
Image Unavailable-75967-724

Anti-TP53 Mouse Monoclonal Antibody [clone: TRP/817]

Catalog Number: (75967-724)
Supplier: Biotium
Description: This antibody recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53 protein. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Image Unavailable-10352-848

Anti-DPYSL2 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10352-848)
Supplier: Bioss
Description: Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
Product Image-10790-676

Uvex Hypershock™ Safety Eyewear, Honeywell Safety

Supplier: Honeywell Safety Products
Description: Uvex Hypershock™ saftey eyewear delivers the ultimate combination of high-performance protection and aggressive sport inspired styling.

Image Unavailable-77561-412

Human Recombinant PI3K (p110 alpha (N345K, His tag)/p85 alpha, His tag), Active (from Baculovirus-Insect Cells)

Supplier: Sino Biological
Description: Recombinant full length human p110 alpha (N345K) mutant subunit and human p85 alpha wild-type subunit were co-expressed by baculovirus in Sf9 insect cells using an N-terminal His tag on both proteins.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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To order chemicals, medical devices, or other restricted products please provide identification that includes your business name and shipping address via email CMD_NA@vwr.com or fax 484.881.5997 referencing your VWR account number . Acceptable forms of identification are:

  • issued document with your organization's Federal Tax ID Number
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