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Image Unavailable-75843-960

Anti-CD4 Rat Monoclonal Antibody (BG Violet 450) [clone: GK1.5]

Catalog Number: (75843-960)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The GK1.5 monoclonal antibody specifically binds with the mouse CD4 molecule, also known as L3T4, a 55 kDa differentiation antigen which binds to the MHC class II. CD4 is expressed on most thymocytes, a subpopulation of mature T lymphocytes, dendritic cells, pluripotent hematopoietic stem cells, B cell precursors, and lymphoid precursors inside the thymus. It is also expressed on the mouse egg cell membrane, enhancing adhesion to MHC class II bearing sperm. By interaction with MHC class II on the surface of APC, CD4 initiates the development of T lymphocytes and helps the optimum functioning of mature T lymphocytes. The binding of the GK1.5 antibody blocks the binding of the Anti-Mouse CD4 RM4-5 antibody.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Image Unavailable-75841-828

Anti-CD44 Rat Monoclonal Antibody (BG Violet 450) [clone: IM7]

Catalog Number: (75841-828)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Image Unavailable-10348-598

Anti-CD40 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10348-598)
Supplier: Bioss
Description: Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Image Unavailable-10390-322

Anti-GNAS Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10390-322)
Supplier: Bioss
Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Stimulates the Ras signaling pathway via RAPGEF2.
Product Image-89415-220

Anti-CRADD Rabbit Polyclonal Antibody

Catalog Number: (89415-220)
Supplier: Prosci
Description: RAIDD Antibody: Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain (DD)-containing receptors, TNFR1 and Fas. The death signals are transduced by a group of DD-containing adapter molecules. A novel cell death adapter was recently identified by two independent groups and designated RAIDD (RIP-associated ICH-1/CED-3-homologous protein with DD) and CRADD (caspase and RIP adapter with DD)1, RAIDD contains a DD and a CARD (for caspase recruitment domain) which interact with RIP and caspase, respectively, to transduce death signals. RAIDD is constitutively expressed in many tissues and mediates apoptosis caused by Fas and TNFR-1.
Image Unavailable-76098-466

Anti-CCR9 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76098-466)
Supplier: Bioss
Description: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
Image Unavailable-10390-394

Anti-GNB2 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10390-394)
Supplier: Bioss
Description: GNB2 belongs to the WD repeat G protein beta family. Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Image Unavailable-10395-358

Anti-GNG2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10395-358)
Supplier: Bioss
Description: GNG2 (Guanine nucleotide binding protein (G protein), gamma 2) is a member of the guanine nucleotide-binding proteins (G proteins) family. Heterotrimeric G proteins are involved as a modulator or transducer in various transmembrane signaling systems. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.
Image Unavailable-77439-750

Anti-MRas Rabbit Polyclonal Antibody

Catalog Number: (77439-750)
Supplier: Bioss
Description: May serve as an important signal transducer for a novel upstream stimuli in controlling cell proliferation. Weakly activates the MAP kinase pathway.
Image Unavailable-10766-414

Anti-CD44 Rat Monoclonal Antibody (violetFluor® 450) [clone: IM7]

Catalog Number: (10766-414)
Supplier: Prosci
Description: The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Product Image-89153-816

Anti-STAT3 Mouse Monoclonal Antibody

Catalog Number: (89153-816)
Supplier: Enzo Life Sciences
Description: The STAT proteins serve as both cytoplasmic signal transducers and nuclear activators of transcription. STAT3 is activated by tyrosine phosphorylation at residue Y705 in cells treated with interleukin-6 or EGF. Activated STAT3 can bind to DNA either as homodimer or as heterodimer with STAT1.
Image Unavailable-76100-946

Anti-IL-6R alpha Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76100-946)
Supplier: Bioss
Description: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
Image Unavailable-76100-948

Anti-IL-6R alpha Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76100-948)
Supplier: Bioss
Description: Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis.
Image Unavailable-75843-062

Anti-CD8a Mouse Monoclonal Antibody (BG Violet 450) [clone: RPA-T8]

Catalog Number: (75843-062)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The RPA-T8 monoclonal antibody specifically reacts with the human CD8a molecule, a 32 kDa cell surface receptor expressed either as a heterodimer (CD8 α/β) or as a homodimer (CD8 α/α) on the majority of thymocytes, a subpopulation of mature T cells, and natural killer cells. CD8 interacts with the major histocompatibility complex class I (MHC class I) molecules on antigen-presenting cells or epithelial cells. The RPA-T8 antibody reacts with 13-48% of peripheral lymphocytes, 80% of thymocytes, and a subset of natural killer cells. RPA-T8, OKT8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitope or block each other by steric hindrance.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.
Image Unavailable-10390-326

Anti-GNAS Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10390-326)
Supplier: Bioss
Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. Stimulates the Ras signaling pathway via RAPGEF2.
Image Unavailable-10390-424

Anti-GNG2 Rabbit Polyclonal Antibody

Catalog Number: (10390-424)
Supplier: Bioss
Description: GNG2 (Guanine nucleotide binding protein (G protein), gamma 2) is a member of the guanine nucleotide-binding proteins (G proteins) family. Heterotrimeric G proteins are involved as a modulator or transducer in various transmembrane signaling systems. The specificity of a G protein-receptor interaction is primarily mediated by the gamma subunit.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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