You Searched For: Octanoyl+chloride

Catalog Number: (TCO0039-100ML)

Supplier: TCI America

Description: CAS Number: 111-64-8
MDL Number: MFCD00000766
Molecular Formula: C8H15ClO
Molecular Weight: 162.66
Purity/Analysis Method: >99.0% (GC)
Form: Clear Liquid
Boiling point (°C): 195
Melting point (°C): -63
Flash Point (°C): 85
Specific Gravity (20/20): 0.95

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Supplier: Thermo Scientific Chemicals

Description: Octanoyl chloride 99%

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Supplier: Thermo Scientific Chemicals

Description: Non-ionic detergent for solubilizing membrane proteins.

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Catalog Number: (700013-926)

Supplier: SPECTRUM CHEMICAL AND MX

Description: Caprylic/Capric Triglyceride is a medium-chain triglyceride used as a component of ointments, creams, and liquid emulsions.

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Supplier: Bachem Americas

Description: Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.

Supplier: Bachem Americas

Description: Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.

Catalog Number: (CAAAJ65946-EXD)

Supplier: Thermo Scientific Chemicals

Description: CAS No.: 313951-59-6
Molecular Formula: C141H235N47O41
Formula Weight: 3244.66
Storage Temperature: -30°C to -10°C
Physical Form: Solid
Appearance: White to off-white
MDL No.: MFCD08460342

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Catalog Number: (H-7252.0500BA)

Supplier: Bachem Americas

Description: Stable isotope-labeled human ghrelin useful for pharmacokinetic/pharmacodynamic studies.

Supplier: Bachem Americas

Description: Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.

Catalog Number: (H-6334.0500BA)

Supplier: Bachem Americas

Description: Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.

Supplier: Bachem Americas

Description: Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.

Catalog Number: (89141-448)

Supplier: Enzo Life Sciences

Description: Ghrelin is a multifunctional peptide hormone secreted from the anterior pituitary known to affect many physiological processes including the release of growth hormone, appetite regulation, gastric acid secretion, gastrointestinal motility, and blood pressure regulation. The 28 amino acid ghrelin peptide is modified at Ser3 by addition of a fatty acid group (i.e., n-octanoyl) that is essential for its biological activity. The ghrelin receptor (GHS-R) is a seven transmembrane (7-TM) GPCR that is expressed in the hippocampus, pituitary, and hypothalamus, as well as in peripheral tissues including the heart, lung, liver, kidney, pancreas, intestines, and immune cells. Ghrelin signals are primarily relayed via coupling of the GHS-R to Gq/11 alpha subunits, promoting stimulation of phospholipase C, and an increase in intracellular calcium. Stimulation of adenylyl cyclases and increased cAMP are also induced by GHS-R activation. In humans and swine, two splice variants of the ghrelin receptor are expressed from the same gene. The GHS-R 1(a) receptor is the 366 amino acid, 7-TM form, while GHS-R 1(b) is a 289 amino acid, 5-TM form that is truncated at the C-terminus and is pharmacologically inactive. The epitope recognized by this antibody is unaffected by alternative splicing.

Supplier: G-Biosciences

Description: Non-ionic detergents have a hydrophilic head group that is uncharged and are preferred for their ability to break lipid-lipid and lipid-protein interactions

Supplier: Bachem Americas

Description: Small synthetic molecules called growth-hormone secretagogues (GHSs) stimulate the release of growth hormone (GH) from the pituitary through a G protein-coupled receptor (GHS-R). Recently, ghrelin ("ghre" is the Proto-Indo-European root of the word "grow") has been identified as an endogenous ligand for GHS-R. These peptides consist of 28 amino acids with an octanoyl-residue at Ser³, which is essential for expressing activity. Ghrelin stimulates GH release from rat primary culture pituitary cells in a dose-dependent manner and induces an increase in intracellular Ca²⁺ in GHS-R-expressing cells with an EC₅₀ value of 2.5 nM. Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin. In future, ghrelin might be used in the treatment of aging patients as well as in patients with idiopathic GH deficiency, obesity, osteoporosis or cardiovascular diseases.

Catalog Number: (BDH7466-1)

Supplier: VWR International

Description: Made with purified water and ACS grade sodium chloride.

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Catalog Number: (BDH7238-1)

Supplier: VWR International

Description: Made with deionized water.

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