You Searched For: Nepsilon-acetyl-L-lysine

Catalog Number: (89160-346)

Supplier: Enzo Life Sciences

Description: Fluor de Lys®-SIRT1 is a fluorogenic, acetylated peptide substrate for SIRT1 (human Sirtuin 1). Based on residues 379-382 of p53 (Arg-His-Lys-Lys(Ac)), a site of regulatory acetylation by the p300 and CBP acetyltransferases (lysines 381, 382), it was the best substrate for SIRT1 from among a panel of substrates patterned on p53, histone H3, and histone H4 acetylation sites. Fluor de Lys®-SIRT1 is deacetylated by SIRT1 (BML-SE239) at a rate of more then 8-fold that of the acetylated lysine substrate, Fluor de Lys® (Prod. No. BML-KI104; acetylated substrates both at 25 µM, 500 µM NAD+). The Km of Fluor de Lys®-SIRT1 for human recombinant Sirtuin 1 is 108 µM (determined at 37°C, 500 µM NAD+). Must be used in conjunction with Fluor de Lys® Developer II (Prod. No. BML-KI176). Fluorescent signal indicates deacetylation of Lys382. Sufficient for 100-200 assays of human recombinant SIRT1 (1U/well, 50-100 µM substrate).

Catalog Number: (103008-864)

Supplier: Anaspec Inc

Description: This peptide is a synthetic peptide corresponding to amino acids 69 to 89 of histone H3. It is acetylated at Lys79 and biotinylated on the C-terminal Lys90. The acetylation of histone H3 at Lysine (K) 79 is observed in vivo in S. cerevisiae.
Sequence:RLVREIAQDF-K(Ac)-TDLRFQSSAV-K(biotin)
MW:2877.4 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: (CARL600406-939)

Supplier: Rockland Immunochemical

Description: This affinity-purified antibody is suitable for use in ELISA and western blotting assays.  The antibody reacts specifically with acetylated lysine residues.

Catalog Number: (10397-830)

Supplier: Bioss

Description: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.

Supplier: Bachem Americas

Description: Sequence: Ac-Lys-OMe · HCl

Catalog Number: (103006-536)

Supplier: Anaspec Inc

Description: This peptide is histone H4, amino acids 1 to 21. It is acetylated at Lys-8 and at the N-terminus with a C-terminus GG linker, followed by a biotinylated lysine. The acetylation of histone H4 causes structural changes that amplify the binding of transcription factors to their recognition sites within the nucleosome.
Sequence:Ac-SGRGKGG-K(Ac)-GLGKGGAKRHRKV-GGK(Biotin)
MW:2644.1 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: (89160-348)

Supplier: Enzo Life Sciences

Description: Fluor de Lys®-HDAC8 is a fluorogenic, diacetylated peptide substrate for HDAC8 (histone deacetylase-8). Based on residues 379-382 of p53 (Arg-His-Lys(Ac)-Lys(Ac)), a site of regulatory acetylation by the p300 and CBP acetyltransferases (lysines 381, 382), it was the best for HDAC8 from among a panel of substrates patterned on p53, histone H3 and histone H4 acetylation sites. Fluor de Lys®-HDAC8 is deacetylated by HDAC8 at a rate of more than 10-fold that of the acetylated lysine substrate, Fluor de Lys® (BML-KI104; substrates both at 100 µM). Although named because of HDAC8’s preference for it, it is also an excellent substrate for SIRT1 (BMl-SE239; 5x the rate of BML-KI104 at 25 µM, 0.5 mM NAD+), SIRT2 and HeLa Nuclear Extract (BML-KI140; 3x KI-104 rate, 25 µM). Must be used in conjunction with Fluor de Lys® Developer II (BML-KI176). Sufficient for 100-200 assays of human recombinant HDAC8 (BML-SE145; 1 U/well, 50-100 µM substrate).

Catalog Number: (103007-662)

Supplier: Anaspec Inc

Description: This is a histone 4 peptide acetylated at lysine 8. In some studies, this histone modification is thought to predict prognosis of resected non-small-cell lung cancer. This peptide has also been shown to play a role in somatic hypermutation (SHM) possible owing to its modification that likely mediates recruitment of error-prone DNA polymerases at the DNA repair stage of SHM.
Sequence:SGRGKGG-K(Ac)-GLGKGGAKRHRK
MW:2034.4 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: (10397-844)

Supplier: Bioss

Description: Histone acetyltransferase which may be involved in transcriptional activation. May influence the function of ATM. As part of the MSL complex it is involved in acetylation of nucleosomal histone H4 producing specifically H4K16ac. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. That activity is less specific than the one of the MSL complex. Can also acetylate TP53/p53 at 'Lys-120'.

Catalog Number: (10162-698)

Supplier: Genetex

Description: Rabbit polyclonal antibody to H3 (acetyl Lys27)

Catalog Number: (103008-536)

Supplier: Anaspec Inc

Description: This peptide is histone H4 amino acids 1 to 16, acetylated at Lys-16 and at the N-terminus. This peptide also contains a GG linker, followed by a biotinylated lysine. The acetylation of histone H4 causes structural changes that play a crucial role in amplifying the binding of transcription factors to specific recognition sites within the nucleosome.
Sequence:Ac-SGRGKGGKGLGKGGA-K(Ac)-RHRKV-GGK(Biotin)
MW:2644.1 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: (103009-188)

Supplier: Anaspec Inc

Description: This peptide is histone H3 (21-43) acetylated at Lys23 with a C-terminal GG linker followed by a biotinylated Lys. Acetylation of histone H3 occurs at Lys14 or Lys23 without preference. Lysine acetylation in histone H3 is associated with transcriptional activation. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:AT-K(Ac)-AARKSAPATGGVKKPHRYRPG-GK(Biotin)
MW:2959.5 Da
% peak area by HPLC:95
Storage condition:-20° C

Catalog Number: (10162-718)

Supplier: Genetex

Description: Rabbit polyclonal antibody to Histone H3R17me2K18ac (dimethyl Arg17, acetyl Lys18)

Catalog Number: (10162-712)

Supplier: Genetex

Description: Rabbit polyclonal antibody to Histone H3K9K14ac (acetyl Lys9/Lys14)

Catalog Number: (10162-696)

Supplier: Genetex

Description: Rabbit polyclonal antibody to H3 (acetyl Lys18)

Catalog Number: (10083-674)

Supplier: Proteintech

Description: BRD8 is one of the bromodomain-containing proteins, which is an acetylated lysine- binding domain and thought to be involved in regulation of protein acetylation and/or HAT (histone acetyl transferase) activity . It is also reported to be an accessory subunit of NuA4 HAT complex (also known as TRRAP/TIP60 complex) through biochemical purification . In addition, it can bind to thyroid hormone receptor-ß and/or retinoid X receptor, and can act as a coactivator of the nuclear hormone receptor-mediated transcription in reporter assays .