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You Searched For: 2-Amino-5-iodopyrimidine


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Image Unavailable-M-2405.0005BA

Mca-(Ala⁷,Lys(Dnp)⁹)-Bradykinin Trifluoroacetate

Description: Substrate V, Mca-RPPGFSAFK(Dnp), is a very sensitive internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1) a membrane-bound zinc metallopeptidase that is related to neprilysin in amino acid sequence. The kcat/Km value for the hydrolysis by ECE-1 was 1.9 x 10⁷ M⁻¹s⁻¹ and 1.7 x 10⁶ M⁻¹s⁻¹ for the hydrolysis by neprilysin. This FRET substrate was hydrolyzed rapidly by stromelysin 1 (MMP-3) with kcat/Km= 218000 M⁻¹s⁻¹ and very slowly by gelatinase B (MMP-9) (kcat/Km= 10100 M⁻¹s⁻¹). There was no hydrolysis by MMP-1 and MMP-2. Mca-RPPGFSAFK(Dnp) has also found use as substrate for insulin-degrading enzyme (IDE) and ACE2.
Catalog Number: M-2405.0005BA
Supplier: Bachem Americas
Product Image-BDH0830-125ML

Sodium (Na+) Single-Element Ion Cation Standard, 1,000 µg/ml (1,000 ppm), VWR Chemicals BDH®

Description: Ion chromatography & ion selective electrode (ISE) standard.
Catalog Number: BDH0830-125ML
Supplier: VWR International

SDS


Image Unavailable-H-6698.0500BA

(Lys²²)-beta-Amyloid (1-40) Trifluoroacetate

Description: The Italian mutation of β-amyloid 1-40 (E22K) aggregates more rapidly than the wild-type sequence 1-40. It showed increased neurotoxicity, which (according to a solid-phase NMR-study of Masuda et al.) may be due to the salt bridge formed between Lys²² and Asp²³ in the minor conformer. As the Arctic, Flemish, and Dutch mutants, the Italian mutant is degraded considerably more slowly than wild-type Aβ by neprilysin.
Catalog Number: H-6698.0500BA
Supplier: Bachem Americas

SDS


Image Unavailable-H-4772.0001BA

Cyclo(-Ala-Arg-Gly-Asp-3-aminomethylbenzoyl) Trifluoroacetate

Description: This small molecule RGD peptidomimetic αvβ3 integrin antagonist contains both anionic and cationic binding sites that straddle the RGD binding domain of the αvβ3 integrin. The IC₅₀ for XJ 735 αvβ3-mediated inhibition of human and porcine cell adhesion, and vascular smooth muscle cell migration, ranged from 0.6 to 4.4 µM. In contrast, IC₅₀ for porcine or human αIIb/β3, α4β1, αvβ5, and α5β1 inhibition exceeded 100 µM.
Catalog Number: H-4772.0001BA
Supplier: Bachem Americas
Image Unavailable-H-9185.0500BA

Dog;Mouse;Pig;Rat Peptide YY (13-36) Trifluoroacetate

Description: This C-terminal fragment was shown to suppress the noradrenaline release from sympathetic nerve endings. It thereby mimics the effects of PYY and NPY at presynaptic (Y₂) receptors. The peptide was also able to compete with NPY for essentially all binding sites in rat brain.
Catalog Number: H-9185.0500BA
Supplier: Bachem Americas
Product Image-CAJT3262-7

L(+)-Potassium sodium tartrate tetrahydrate 99.0-102.0%, crystals, BAKER ANALYZED® ACS, J.T.Baker®

Description: L(+)-Potassium sodium tartrate tetrahydrate ≥99%, crystals, BAKER ANALYZED® ACS
Catalog Number: CAJT3262-7
Supplier: VWR International

Certificates


Image Unavailable-H-2734.0500BA

Chicken;Human;Mouse;Pig;Rat;Sheep PACAP-38 (6-38) Trifluoroacetate

Description: The PACAP selective antagonist PACAP (6-38) is a potent and selective inhibitor of PACAP-27-stimulated pituitary adenylate cyclase with a Ki values of 150 nM.
Catalog Number: H-2734.0500BA
Supplier: Bachem Americas
Product Image-BDH9286-500G

Sodium chloride ≥99.0% ACS analytical reagent, VWR Chemicals BDH®

Description: Meets reagent specifications for testing USP/NF monographs.
Catalog Number: BDH9286-500G
Supplier: VWR International

SDS Certificates


Image Unavailable-H-8420.1000BA

Human C-Type Natriuretic Peptide (1-53) Trifluoroacetate

Description: CNP, a member of the natriuretic peptide family, was first identified in porcine brain and later found in other mammals as well as non-mammals. Processing of the CNP precursor gives rise to CNP-22 and its N-terminally elongated form, CNP-53. The CNPs share considerable sequence homology with ANP and BNP within the disulfide loop and exert similar pharmacological actions, although with different relative potencies. CNP-22 is a potent and selective activator of the human BNP cell surface receptor, a transmembrane guanylyl cyclase. This ligand-receptor pair may be involved in the regulation of fluid homeostasis by the central nervous system.
Catalog Number: H-8420.1000BA
Supplier: Bachem Americas
Image Unavailable-H-4174.1000BA

Human Orexin B Trifluoroacetate, Bachem

Description: Like orexin A, orexin B (OXB) is a hypothalamic neuropeptide regulating the feeding behavior. Central administration of OXB to rats stimulated food consumption in a similar manner to orexin A, but the effect did not last as long as that of orexin A. The affinity of orexin B for the OX₁ receptor is significantly lower (IC₅₀ = 240 nM) than that of orexin A. Binding affinities for the OX₂ receptor are similar for orexin A and B (IC₅₀ = 38 nM and 36 nM, respectively, for displacement of radiolabeled orexin A bound to the receptor).
Catalog Number: H-4174.1000BA
Supplier: Bachem Americas
Image Unavailable-H-4834.0005BA

(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid beta/A4 Protein Precursor₇₇₀ (667-676) Trifluoroacetate

Description: This peptide substrate corresponds to the 'Swedish' Lys-Met/Asn-Leu (K670N/M671L) mutation of the amyloid precursor protein (APP) β-secretase cleavage site. It has been used for assaying β-secretase activity.
Catalog Number: H-4834.0005BA
Supplier: Bachem Americas
Image Unavailable-H-4716.0001BA

Bovine;Human;Rat ACTH (3-24) Trifluoroacetate

Description: Please see also α-MSH (corresponds to acetyl-ACTH (1-13) amide, H-1075), α-MSH (free acid) (acetyl-ACTH (1-13), H-1070), and (Des-acetyl)-α-MSH (H-4390). Wied: Pituitary Adrenal System Hormones and Behaviour. Symposium on Developments in Endocrinology (1976) / Anon.: ACTH and Related Peptides: Structure, Regulation, and Action. Ann. N.Y. Acad. Sci. 297, 1 (1977) / A.V.Schally: Aspects of Hypothalamic Regulation of the Pituitary Gland. Science 202, 18 (1978) / R.Schwyzer: Studies on Polypeptide Receptors. A Critical View on the Mechanism of ACTH Action. Bull. Schweiz. Acad. Med. Wiss. 34, 263 (1978).
Catalog Number: H-4716.0001BA
Supplier: Bachem Americas
Image Unavailable-H-6126.0500BA

Retrocyclin-1 Trifluoroacetate

Description: Antimicrobial peptides are produced by plants and most organisms throughout the animal kingdom including humans. Antimicrobial peptides protect against a broad range of infectious agents, as bacteria, fungi, and viruses. The amphibian skin is an especially rich source of antimicrobial peptides. See also the product families: Hepcidins LL-37 and Fragments Tuftsin and Analogs (subfamily).
Catalog Number: H-6126.0500BA
Supplier: Bachem Americas
Image Unavailable-H-1296.0500BA

Human;Pig;Rat C-Type Natriuretic Peptide (32-53) Trifluoroacetate

Description: CNP, a member of the natriuretic peptide family, was first identified in porcine brain and later found in other mammals as well as non-mammals. Processing of the CNP precursor gives rise to CNP-22 and its N-terminally elongated form, CNP-53. The CNPs share considerable sequence homology with ANP and BNP within the disulfide loop and exert similar pharmacological actions, although with different relative potencies. CNP-22 is a potent and selective activator of the human BNP cell surface receptor, a transmembrane guanylyl cyclase. This ligand-receptor pair may be involved in the regulation of fluid homeostasis by the central nervous system.
Catalog Number: H-1296.0500BA
Supplier: Bachem Americas
Product Image-BDH9288-2.5KG

tri-Sodium citrate dihydrate ≥99.0% ACS, VWR Chemicals BDH®

Description: Colorless or white solid
Catalog Number: BDH9288-2.5KG
Supplier: VWR International

SDS Certificates


Image Unavailable-H-5962.0005BA

Human Kisspeptin-13 Trifluoroacetate

Description: An LRF-amide motif containing fragment of malignant melanoma metastasis suppressor KiSS-1. It bound with low nanomolar affinity to the rat and human G protein-coupled receptor GPR54 expressed in Chinese hamster ovary K1 cells and stimulated PIP₂ hydrolysis, Ca²⁺ mobilization, arachidonic acid release, ERK1/2 and p38 MAP kinase phosphorylation, and stress fiber formation but inhibited cell proliferation.
Catalog Number: H-5962.0005BA
Supplier: Bachem Americas
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