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Anti-MSK1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10372-050)
Supplier: Bioss
Description: MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress. Similar to RSK, MSK1 contains two kinase domains (N term and a C term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain.
Image Unavailable-10372-082

Anti-MSK1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10372-082)
Supplier: Bioss
Description: MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress. Similar to RSK, MSK1 contains two kinase domains (N term and a C term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain.
Product Image-10372-086

Anti-MSK1 Rabbit Polyclonal Antibody

Catalog Number: (10372-086)
Supplier: Bioss
Description: MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress. Similar to RSK, MSK1 contains two kinase domains (N term and a C term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain.
Image Unavailable-10369-820

Anti-MSK1 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10369-820)
Supplier: Bioss
Description: MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress. Similar to RSK, MSK1 contains two kinase domains (N term and a C term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain.
Image Unavailable-10083-236

Anti-ATF6B Rabbit Polyclonal Antibody

Catalog Number: (10083-236)
Supplier: Proteintech
Description: The endoplasmic reticulum (ER)-transmembrane proteins, ATF6 alpha (ATF6) and ATF6 beta (ATF6B), are cleaved during the ER stress response (ERSR). The resulting N-terminal fragments of both ATF6 isoforms, which have conserved basic leucine-zipper and DNA binding domains but divergent transcriptional activation domains, translocate to the nucleus where they bind to ER stress-response elements (ERSE) in ERSR, such as Bip/GRP78. This antibody could recognize ATF6 beta (110kd) and its cleaved forms(60,80kd )
Product Image-MFLX77915-10

Masterflex® L/S® PTFE-Diaphragm Pump System, Avantor®

Catalog Number: (MFLX77915-10)
Supplier: Avantor Fluid Handling
Description: Ideal for chemical feed/metering and applications requiring high-purity, high-pressure or both.

ISO9001 CE Compliant


Product Image-77868-046

Orion™ Pro Star MP218 pH/Ion/Conductivity/DO Bench Meters

Supplier: Thermo Fisher Scientific
Description: <p>The Thermo Scientific™ Orion™ Pro Star MP218 pH/ion, conductivity, and dissolved oxygen bench meter is designed to provide accurate, reliable electrochemistry testing. Featuring an intuitive interface, enhanced data reporting and robust functionality, the Orion™ Pro Star MP218 meter delivers advanced performance in a modern and simplified package.</p>

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Product Image-82027-602

VWR® Multipurpose Scissors, 7¹/₄"

Catalog Number: (82027-602)
Supplier: VWR International
Description: Constructed of heat-treated stainless steel, these scissors are great for home projects and general use.
Product Image-97011-776

Pure Water Meter, Sper Scientific

Catalog Number: (97011-776)
Supplier: Sper Scientific
Description: Measures conductivity (in a wide range of 0.1 μS to 199 mS), salinity, TDS (total dissolved solids), and temperature. Useful in industrial water testing.
Image Unavailable-10088-530

Anti-HTRA2 Rabbit Polyclonal Antibody

Catalog Number: (10088-530)
Supplier: Proteintech
Description: HTRA2(High temperature requirement protein A2) is also named as OMI, PRSS25 and belongs to the peptidase S1B family. HTRA2 normally exists in the mitochondria, can cause MMP3 activation in the cytosol under a cell stress condition, which can ultimately lead to demise of dopaminergic neuronal cells. It inhibits mitochondrial superoxide generation, stabilizes mitochondrial membrane potential, and prevents apoptosis at baseline and in response to extracellular inducers of mitochondrial stress. This protein has 4 isoforms produced by alternative splicing.
Product Image-10096-534

Anti-TXNL1 Rabbit Polyclonal Antibody

Catalog Number: (10096-534)
Supplier: Proteintech
Description: TXNL1(Thioredoxin-like protein 1) is also named as TRP32, TXL, TXNL and belongs to the thioredoxin family. It might be involved in the cellular response to sugar starvation stress. The predicted 289-amino acid, 32.3-kD protein has 2 distinct domains: an N-terminal domain, which is 43% identical to human TXN, and a C-terminal domain, which showed no homology to other proteins in the sequence databases.TXNL1 functions as an effector of oxidants or redox sensor that couples oxidative stress to endocytosis, by converting redox changes into a specific GDI:Rab5-mediated endocytic response.
Product Image-89417-500

Anti-FOXO3 Rabbit Polyclonal Antibody

Catalog Number: (89417-500)
Supplier: Prosci
Description: FOXO3 Antibody: FOXO3 is a ubiquitously expressed 75 kDa protein member of a subfamily of the forkhead homeotic gene family of transcription factors and shuttles between the cytoplasm and nucleus. FOXO transcription factors are key players of cell fate decisions, metabolism, stress resistance, tumor suppression and are regulated by growth factors, oxidative stress or nutrient deprivation. FOXO3 is involved with mTOR in the regulation of autophagy in skeletal muscle, and activates protein degradation in atrophying muscle cells. FOXO3 has also been implicated in several neurodegenerative disorders including aging, neuromuscular disease, systemic lupus erythmatosus, stroke and diabetic complications.
Product Image-71000-176

Vials with Poly-Seal Screw Cap, Ace Glass Incorporated

Supplier: Ace Glass
Description: USP Type 1 borosilicate glass vials feature Poly-Seal cone-lined closures which are molded in a premium grade, natural low density polyethylene to help prevent deforming and stress cracking.

Small Business Enterprise Product available on GSA Advantage®

Product Image-89416-506

Anti-RTP801 Rabbit Polyclonal Antibody

Catalog Number: (89416-506)
Supplier: Prosci
Description: RTP801 Antibody: RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
Product Image-76208-092

Oakton® PCTS Testr™ 50 Waterproof Pocket pH/Cond/TDS/Salinity Tester, Premium 50 Series, Cole-Parmer

Catalog Number: (76208-092)
Supplier: Antyila Scientific
Description: Ultimate tester for pH, conductivity, TDS, salinity, and temperature!
Image Unavailable-76081-336

Anti-GADD45B Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76081-336)
Supplier: Bioss
Description: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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