You Searched For: O-tert-Butyl-L-tyrosine


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Catalog Number: (10782-480)
Supplier: Biosensis
Description: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. FUNCTION: Plays an important role in the physiology of adrenergic neurons. CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin. COFACTOR: Fe(2+) ion. ENZYME REGULATION: Phosphorylation leads to an increase in the catalytic activity. PATHWAY: Catecholamine biosynthesis; first step. SUBUNIT: Homotetramer. PTM: In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation. SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are a consistent neurochemical abnormality.


Catalog Number: (77439-292)
Supplier: Bioss
Description: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Telomerase are large DNA-protein complexes with telomerase expression being the subject of recent research due to its link to cell immortalization. Recent evidence has shown that MYC upregulates the catalytic subunit of telomerase, TERT, and that Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008].


Catalog Number: (89163-776)
Supplier: Enzo Life Sciences
Description: Produced in <i>E. coli</i>. T-cell phosphatase with a C-terminal 11 kDa deletion (TCdeltaC11) (aa 1-317).


Supplier: Piercan USA
Description: These high-quality gloves are an industry standard and great value.

Supplier: TCI America
Description: CAS Number: 68621-88-5
MDL Number: MFCD06657915
Molecular Formula: C11H16N2O2
Molecular Weight: 208.26
Purity/Analysis Method: >98.0% (GC,T)
Form: Crystal

SDS

Catalog Number: (77131-028)
Supplier: Prosci
Description: TERT Peptide


Supplier: Thermo Scientific Chemicals
Description: 2-Methylpropane-2-sulfinamide 97%
Catalog Number: (CAPI14679)
Supplier: Thermo Scientific
Description: This antibody is specific for the ~60 kDa Tyrosine Hydroxylase in Western blots of rat brain extracts. Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines Dopamine and Norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al. , 2001; Zhu et al. , 2000; Zhu et al. , 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al. , 2000; Salvatore et al. , 2001).


Catalog Number: (89357-278)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to Tyrosine Hydroxylase (tyrosine hydroxylase)


Supplier: TCI America
Description: CAS Number: 13081-32-8
MDL Number: MFCD00083642
Molecular Formula: C10H21NO2
Molecular Weight: 223.74
Purity/Analysis Method: >98.0% (N,T)
Form: Crystal
Specific rotation [a]20/D: -19 deg (C=2, EtOH)

SDS

Supplier: MilliporeSigma
Description: Formaldehyde Diethyl Acetal (Stabilised with 2, 6-Di-Tert-Butyl-4-Methylphenol) for Synthesis Cas Number 462-95-3250Ml

SDS

Catalog Number: (SXS-2455)
Supplier: SPEX CERTIPREP LLC
Description: Single-Component organic standards.


Catalog Number: (10075-368)
Supplier: Prosci
Description: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004).


Supplier: DWK Life Sciences (KIMBLE)
Description: Lyophilization style, slotted stopper for aluminum seals.
Catalog Number: (76533-516)
Supplier: ILC DOVER LP
Description: The only CBRN loose-fitting powered air purifying respirator (PAPR) hood designed to deliver a CAP 2 protection rating when used with the Sentinel XL® blower.


Catalog Number: (CA10816-792)
Supplier: Biolegend
Description: Tyrosine Hydroxylase Monoclonal Antibody, Clone: 2/40/15, Host: Mouse, Isotype: IgG2a, Reactivity: Human, Mouse, Rat, Immunogen: purified Tyrosine Hydroxylase from rat Pheochromocytoma tumor, Conjugate: Purified, Application: WB, IHC, Size: 100 ul


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