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Description: Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf and Nicola). G-CSF causes a range of effects including a transient reduction of SDF-1 expression (Petit <i>et al.</i>), the activation of metalloproteases that cleave VCAM-1 (Levesque <i>et al.</i>), and the release of norepinephrine from the sympathetic nervous system (Katayama <i>et al.</i>), leading to the release or mobilization of hematopoietic stem cells from the bone marrow into the periphery. The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. In addition to hematopoietic cells, G-CSF is also expressed in cardiomyocytes, neuronal cells, mesothelial cells, and endothelial cells. Mouse G-CSF was first purified from cultures of the WEHI-3B myelomonocytic leukemia cell line as the inducer of the terminal differentiation of WEHI-3B and other myeloid leukemia cell lines (Nicola <i>et al.</i>). It was later cloned in monkey COS cells from a cDNA library prepared with mRNA derived from mouse fibrosarcoma NFSA cells that produce G-CSF constitutively (Tsuchiya <i>et al.</i>). Binding of G-CSF to its receptor leads to activation of the JAK/STAT, MAPK, PI3K, and AKT signal transduction pathways.
Catalog Number: MSPP-780141006
Supplier: STEMCELL Technologies

New Product


Description: Recombinant Plants Phl p 7 (7.0101) (from E. coli)
Catalog Number: 76835-082
Supplier: ANTIBODIES.COM LLC


Description: For chloride determination by argentometric buret titration.
Catalog Number: CA11016-518
Supplier: Hach


Description: APC anti-human CD141 (Thrombomodulin) [M80]; Isotype: Mouse IgG1, κ; Reactivity: Human, African Green, Baboon; Apps: FC; Size: 100 tests
Catalog Number: CA344105-BL
Supplier: Biolegend


Description: Recombinant Wasp Ves v 5 (5.0101) (from Insect cells)
Catalog Number: 76835-400
Supplier: ANTIBODIES.COM LLC


Description: Recombinant Plants Phl p 6 (6.0101) (from E. coli)
Catalog Number: 76835-066
Supplier: ANTIBODIES.COM LLC


Description: Recombinant Multiple Ara h 1 (1.0101) (from E. coli)
Catalog Number: 76836-060
Supplier: ANTIBODIES.COM LLC


Description: Recombinant Plants Phl p 2 (2.0101) (from E. coli)
Catalog Number: 76834-546
Supplier: ANTIBODIES.COM LLC


Description: Recombinant Multiple Ara h 8 (8.0101) (from E. coli)
Catalog Number: 76833-294
Supplier: ANTIBODIES.COM LLC


Description: Recombinant Cat Fel d 1 (1.0101) (from E. coli)
Catalog Number: 76836-360
Supplier: ANTIBODIES.COM LLC


Description: Recombinant Plants Bet v 2 (2.0101) (from E. coli)
Catalog Number: 76833-584
Supplier: ANTIBODIES.COM LLC


Description: CAS Number: 100-54-9
MDL Number: MFCD00006372
Molecular Formula: C6H4N2
Molecular Weight: 104.11
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Boiling point (°C): 201
Melting point (°C): 50
Flash Point (°C): 84
Catalog Number: TCC0456-500G
Supplier: TCI America

Description: CAS Number: 170141-63-6
MDL Number: MFCD00042403
Molecular Formula: C9H7F3O2
Molecular Weight: 204.15
Purity/Analysis Method: >97.0% (GC)
Form: Clear Liquid
Color: Colorless
Flash Point (°C): 83
Specific Gravity (20/20): 1.29
Catalog Number: TCT1587-005G
Supplier: TCI America

SDS


Description: CAS Number: 50541-93-0
MDL Number: MFCD00006504
Molecular Formula: C12H18N2
Molecular Weight: 190.29
Purity/Analysis Method: >98.0% (GC,T)
Form: Clear Liquid
Flash Point (°C): 110
Specific Gravity (20/20): 1.01
Catalog Number: TCA1086-025G
Supplier: TCI America

SDS


Description: CAS Number: 52722-86-8
MDL Number: MFCD01321174
Molecular Formula: C11H23NO2
Molecular Weight: 201.31
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Melting point (°C): 186
Flash Point (°C): 140
Catalog Number: TCH0931-005G
Supplier: TCI America

Description: CAS Number: 10114-58-6
MDL Number: MFCD00012977
Molecular Formula: C18H18N8
Molecular Weight: 419.31
Form: Crystal
Color: Deep Yellow Red
Catalog Number: TCB0780-025G
Supplier: TCI America