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Supplier: Diagnostic Biosystems
Description: This antibody is specific to a membrane glycoprotein of 45 kDa, designated as CD23. CD23 is found on a subpopulation of peripheral blood cells, B lymphocytes and on EBV transformed B lymphoblastoid cell lines. Expression of CD23 has been detected in neoplastic cells from cases of B cell chronic lymphocytic leukemias.

Catalog Number: (CA76634-448)
Supplier: Diagnostic Biosystems
Description: This antibody reacts with a 49 kDa protein. At least five CD1 genes are identified (CD1a, b, c, d and e). This antibody reacts with cortical thymocytes, Langerhans cells in epidermis, dendritic cells of dermis and Langerhans cells of mucosa of tonsil. This antibody may be useful in the characterization of leukemias and lymphomas.


Supplier: Diagnostic Biosystems
Description: Chromogranin A is a 439 amino acid protein present in secretory granules of a wide variety of endocrine cells and neurons. A positive staining is seen in the secretory granules of parathyroid, adrenal medulla, anterior pituitary gland and Langerhans islets of pancreas. This antibody stains a variety of neuroendocrine tumors.

Catalog Number: (CA76634-312)
Supplier: Diagnostic Biosystems
Description: This antibody does not show any cross-reactivity with kappa light chain. It stains B cell follicles in human lymphoid tissues. The mantle zone shows a mosaic pattern of labeling while the germinal centers show a coarse meshwork pattern of staining.


Supplier: Diagnostic Biosystems
Description: Inhibin is a dimeric glycoprotein hormone from the TGF-β family made of β and α subunits. This antibody recognizes the 32kDa α subunit of human inhibin. Inhibin α is expressed in a wide variety of human tissues, such as brain, prostate, adrenal, granulose cells of ovary, sertoli cells of testis and in fetoplacental unit.

Catalog Number: (CA76634-496)
Supplier: Diagnostic Biosystems
Description: This antibody recognizes collagen type IV epitope located on the α1 and/or α 2 chains of human collagen type IV. This antibody shows no cross-reactivity with collagen types I, II, III, V, VI and VII and does not react with human vitronectin, fibronectin or chondroitin sulfate A, B and C.


Catalog Number: (CA76634-476)
Supplier: Diagnostic Biosystems
Description: The Bcl-2 product is considered to act as an inhibitor of apoptosis. Bcl-2 expression is inhibited in germinal centers where apoptosis forms part of the B cell production pathway. Reactive follicles show no staining for Bcl-2, whereas the cells in neoplastic follicles exhibit membrane staining. Bcl-2 α oncoprotein has been shown to inhibit apoptosis.


Catalog Number: (CA76634-394)
Supplier: Diagnostic Biosystems
Description: This antibody is specific to 160 kDa protein known as Factor XIII-A. Factor XIII is a β-globulin found in plasma and is composed of two subunits, Factor XIII-A and Factor XIII-B. Factor XIII-A is the catalytic subunit and is a dimer of M.W. 160 kDa. Factor XIII is a dermal dendrocyte marker and v variable reaction with these types of tumors.


Supplier: Diagnostic Biosystems
Description: This antibody is specific to 60 kDa latent membrane protein (LMP-1) encoded by the BNLF1 gene of the EBV. Each clone reacts with different epitopes on the hydrophilic C-terminus of the cytoplasmic domain of LMP-1. This antibody stains strongly with EBV positive lymphoblastoid cell lines and EBV infected B cell immunoblasts in infectious mononucleosis.

Catalog Number: (CA76634-426)
Supplier: Diagnostic Biosystems
Description: Hepatoblastoma is the most common primary tumor of the liver in children. The use of specific hepatocyte markers and of α-fetoprotein or carcinoembryonic antigen are useful for the identification of normal and malignant fetal hepatocytes. This antibody recognizes an uncharacterized antigen present in both adults and fetal normal hepatocytes to produce a distinct granular cytoplasmic staining. This antibody stains majority of hepatocellular carcinomas.


Supplier: Diagnostic Biosystems
Description: This antibody is specific to 50 kDa cytokeratin protein designated cytokeratin 14. Cytokeratin 14 belongs to the type A (acidic) subfamily of low molecular weight cytokeratins and exists in combination with cytokeratin 15. This antibody can be used to distinguish stratified epithelial cells from simple epithelial cells.

Catalog Number: (CA76634-336)
Supplier: Diagnostic Biosystems
Description: This antibody reacts with the β chain of all products of the gene sub regions DP, DQ, and DR. It stains B cells, interdigitating reticulum cells, Langerhans cells and many macrophages. This antibody does not react with normal T cell and polymorphs, but stains activated T cells.


Catalog Number: (CA76634-488)
Supplier: Diagnostic Biosystems
Description: This antibody is specific to a protein of 27 kDa known as p27Kip1 a cell cycle regulatory mitotic inhibitor. This antibody recognizes an epitope between amino acids 83-204 of p27. This antibody does not show any cross-reactivity with other related mitotic inhibitors.


Catalog Number: (CA76634-364)
Supplier: Diagnostic Biosystems
Description: This antibody recognizes keratin polypeptide of 54 kDa. It stains strongly with non-squamous epithelium but does not stain squamous epithelium. It reacts with the sweat gland and ducts in the skin. Adenocarcinomas of the ovary, gastrointestinal tract, ductal carcinoma of breast, pancreas and bile ducts, stain positive with this antibody.


Supplier: Diagnostic Biosystems
Description: This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell chymase is considered to be an important marker of mast cells and is an important mediator of inflammation.

Supplier: Diagnostic Biosystems
Description: This antibody is specific to a cluster of proteins between 19-22 kDa (reduced). VEGF is a homodimeric disulfide-linked glycoprotein involved in angiogenesis, which promotes tumor progression and metastasis. It exhibits potent mitogenic and permeability-inducing properties specific for the vascular endothelium.

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