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Supplier: Zymo Research
Description: <p>Part of the ZymoPURE plasmid kits collection, the ZymoPURE II<strong>™</strong> plasmid maxiprep kits provides the fastest and simplest method available to efficiently isolate up to 3 mg of transfection grade plasmid DNA from <em>E. coli.</em></p>

Catalog Number: (77437-594)
Supplier: Bioss
Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Regulation of gene expression levels depends on the balance between methylation and acetylation levels of tha CTD-lysines (By similarity). Initiation or early elongation steps of transcription of growth-factors-induced immediate early genes are regulated by the acetylation status of the CTD (PubMed:24207025). Methylation and dimethylation have a repressive effect on target genes expression


Catalog Number: (10409-888)
Supplier: Bioss
Description: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.


Catalog Number: (10409-892)
Supplier: Bioss
Description: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.


Catalog Number: (76203-036)
Supplier: Orflo
Description: Moxi GO II™ combines two instruments to deliver amazingly affordable, easy to use, maintenance-free, gold standard cell count accuracy and precision through the Coulter Principle and integrating 2 channels of flow cytometry. This unique combination covers a large number of routine cell assays (cell count, cell volume, viability, cell proliferation, transfection checks, apoptosis, phenotyping, cellular response) with quantitative single cell data output.

Environmentally Preferable cUL Listed CE Compliant CSA Certified


Catalog Number: (10409-898)
Supplier: Bioss
Description: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.


Catalog Number: (76250-528)
Supplier: NEWARK/ELEMENT 14 TE
Description: Converts BNC cables with male plugs to stackable banana plugs for versatility.


Supplier: Abcam
Description: Rabbit monoclonal [EPR20295-40] to Hexokinase II - BSA and Azide free (Detector).

New Product

Supplier: Abcam
Description: Rabbit monoclonal [EPR3876] to Angiotensin II Type 2 Receptor.

New Product

Catalog Number: (89303-532)
Supplier: Genetex
Description: Mouse Monoclonal antibody to MHC Class II Rt1Bu/L Clone: OX-3 Conjugation: FITC Species Reactivity: Mouse Rat Tested Applications: FACS Pkg Size: 100 ug


Supplier: Epredia
Description: Cassette II biopsy cassettes are designed for ease of use and print clarity.

Catalog Number: (77042-786)
Supplier: ANTIBODIES.COM LLC
Description: Rabbit polyclonal antibody to Heparin Cofactor II for IHC, IF and ELISA with samples derived from Human, Mouse and Rat.


Catalog Number: (ABCA_AB8161-500UL)
Supplier: Abcam
Description: Mouse monoclonal [MR2-1] to TNF Receptor II.

New Product


Catalog Number: (ABCA_AB243843-100U)
Supplier: Abcam
Description: Mouse monoclonal [OX3] to MHC Class II.

New Product


Supplier: Starplex
Description: Sterile, ready to use units for the collection and transport of bacteriological specimens

Supplier: Sartorius
Description: The Cubis® II laboratory balances are modular, providing choice between applications and configurations that best suits the labratory needs. These balances can be configured at the level of display, draftshields, software applications and hardware functions. The Cubis® II range of high-capacity micro balances with a maximum load of between 32 and 111 g and a readability between 0.001 and 0.002 mg provide the ideal choice for a broad range of applications.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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