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Image Unavailable-10394-510

Anti-SLC9A9 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10394-510)
Supplier: Bioss
Description: Slc9a9 (Sodium/hydrogen exchanger 9) or NHE9 may act in electroneutral exchange of protons for Na(+) across membranes. Four isoforms of the Na+/H+ exchanger (NHE6-NHE9) are distributed to intracellular compartments in human cells. They are localized to Golgi and post-Golgi endocytic compartments as follows: mid- to trans-Golgi, NHE8; trans-Golgi network, NHE7; early recycling endosomes, NHE6; and late recycling endosomes, NHE9. The intracellular localization of the NHEs is established by the balance of transport in and out of the post-Golgi compartments as the dynamic membrane trafficking. Their in vivo function is to regulate the pH and monovalent cation concentration in these organelles.
Product Image-10102-816

Anti-SLC5A5 Rabbit Polyclonal Antibody

Catalog Number: (10102-816)
Supplier: Prosci
Description: The sodium-iodide symporter (NIS, or SLC5A5) is a key plasma membrane protein that mediates active I- uptake in thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na+ per I-. In thyroid, NIS-mediated I- uptake is the first step in the biosynthesis of iodine-containing thyroid hormones.The sodium-iodide symporter (NIS, or SLC5A5) is a key plasma membrane protein that mediates active I- uptake in thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na+ per I-. In thyroid, NIS-mediated I- uptake is the first step in the biosynthesis of iodine-containing thyroid hormones (Dohan et al., 2007 [PubMed 18077370]).
Image Unavailable-75888-478

Anti-FCGR3A Mouse Monoclonal Antibody (CF405S) [clone: HO-80]

Supplier: Biotium
Description: This antibody recognizes CD16 (FcγRIII), the low-affinity receptor for IgG with an apparent molecular weight of 50-80 kDa. Two similar genes represent CD16, CD16A (FcγRIIIA), which exists as a hetero-oligomeric polypeptide-anchored form in macrophages and NK cells and CD16B (FcγRIIIB), which exist as a monomeric GPI-anchored form in neutrophils. Furthermore, there are two known polymorphisms of CD16B, NA-1 and NA-2. Individuals homozygous for NA-2 show a lower phagocytic capacity compared with NA-1. CD16 binds IgG in the form of immune complexes and shows preferential binding of IgG1 and IgG3 isotypes and minimal binding of IgG2 and IgG4. Upon IgG binding, both CD16 isoforms initiate signal transduction cascades that lead to a variety of responses including antibody-dependent cell-mediated cytotoxicity (ADCC), phagocytosis, degranulation and proliferation.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Image Unavailable-10085-978

Anti-FXYD6 Rabbit Polyclonal Antibody

Catalog Number: (10085-978)
Supplier: Proteintech
Description: The FXYD family is a group of small single-span transmembrane proteins characterized by a signature sequence containing an FXYD motif, two conserved glycines and a serine residue. Members of the FXYD family, including FXYD1 (phospholemman), FXYD2 (gamma subunit of Na,K-ATPase), FXYD3 (Mat8), FXYD4 (CHIF), FXYD5 (RIC), FXYD6 (phosphohippolin) and FXYD7, are tissue specific regulators of the Na,K-ATPase. FXYD6 is primarily expressed in the brain. It modulates the kinetic activity of Na,K-ATPase and has long-term physiological importance in maintaining cation homeostasis. It may play a role in endolymph composition, and has a potential important role in neuronal excitability of the CNS during postnatal development and in the adult brain. On the SDS-PAGE FXYD6 migrates with an apparent molecular weight of approximately 20 kDa, which is larger than the calculated molecular weight of 10.5 kDa . The gene encodes FXYD6 is located on chromosome 11q23.3, and it might be a susceptibility gene of schizophrenia.
Image Unavailable-10394-512

Anti-SLC9A9 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10394-512)
Supplier: Bioss
Description: Slc9a9 (Sodium/hydrogen exchanger 9) or NHE9 may act in electroneutral exchange of protons for Na(+) across membranes. Four isoforms of the Na+/H+ exchanger (NHE6-NHE9) are distributed to intracellular compartments in human cells. They are localized to Golgi and post-Golgi endocytic compartments as follows: mid- to trans-Golgi, NHE8; trans-Golgi network, NHE7; early recycling endosomes, NHE6; and late recycling endosomes, NHE9. The intracellular localization of the NHEs is established by the balance of transport in and out of the post-Golgi compartments as the dynamic membrane trafficking. Their in vivo function is to regulate the pH and monovalent cation concentration in these organelles.
Image Unavailable-89160-028

12(R)-Hydroxyeicosa-5Z,8Z,10E,14Z-tetraenoic acid (HETE) ≥99%

Catalog Number: (89160-028)
Supplier: Enzo Life Sciences
Description: Biosynthesis in psoriatic skin and corneal epithelial cells via cytochrome P-450. More potent than 12(S)-HETE in inducing human leukocyte chemokinesis and aggregation. Proinflammatory effects in human skin. Inhibits renal, cardiac and corneal Na+,K+-ATPase. Reduces intraocular pressure.
Image Unavailable-10394-506

Anti-SLC9A9 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10394-506)
Supplier: Bioss
Description: Slc9a9 (Sodium/hydrogen exchanger 9) or NHE9 may act in electroneutral exchange of protons for Na(+) across membranes. Four isoforms of the Na+/H+ exchanger (NHE6-NHE9) are distributed to intracellular compartments in human cells. They are localized to Golgi and post-Golgi endocytic compartments as follows: mid- to trans-Golgi, NHE8; trans-Golgi network, NHE7; early recycling endosomes, NHE6; and late recycling endosomes, NHE9. The intracellular localization of the NHEs is established by the balance of transport in and out of the post-Golgi compartments as the dynamic membrane trafficking. Their in vivo function is to regulate the pH and monovalent cation concentration in these organelles.
Image Unavailable-77439-618

Anti-BTR1 Rabbit Polyclonal Antibody

Catalog Number: (77439-618)
Supplier: Bioss
Description: Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration (By similarity). Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.
Image Unavailable-76085-662

Anti-SLC9A9 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76085-662)
Supplier: Bioss
Description: Slc9a9 (Sodium/hydrogen exchanger 9) or NHE9 may act in electroneutral exchange of protons for Na(+) across membranes. Four isoforms of the Na+/H+ exchanger (NHE6-NHE9) are distributed to intracellular compartments in human cells. They are localized to Golgi and post-Golgi endocytic compartments as follows: mid- to trans-Golgi, NHE8; trans-Golgi network, NHE7; early recycling endosomes, NHE6; and late recycling endosomes, NHE9. The intracellular localization of the NHEs is established by the balance of transport in and out of the post-Golgi compartments as the dynamic membrane trafficking. Their in vivo function is to regulate the pH and monovalent cation concentration in these organelles.
Image Unavailable-76101-588

Anti-AQP9 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76101-588)
Supplier: Bioss
Description: Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol.
Product Image-77394-714

Lentivirus Pseudotyped Influenza A HPAI H5N1 virus HaNaM with Luciferase Reporter (clade 2.3.4.4b, 2022 strain)

Supplier: ReVacc Scientific
Description: This pseudotyped virus uses lentivirus packaging to carry full length HA, NA and M of Highly Pathogenic Avian Influenza (HPAI) A virus (A/Pelecanus/Peru/VFAR-140/2022(H5N1), clade 2.3.4.4b) (GenBank: OQ565628.1). The pseudotypes can be handled using BSL-2 containment practices.

Product Image-10108-986

Anti-SLC38A4 Rabbit Polyclonal Antibody

Catalog Number: (10108-986)
Supplier: Prosci
Description: SLC38A4 is found predominantly in liver and transports both cationic and neutral amino acids. The transport of cationic amino acids by SLC38A4 is Na (+) and pH independent, while the transport of neutral amino acids is Na (+) and pH dependent.The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene.
Product Image-10147-798

Falcon® 96-Multiwell Insert Systems, Corning

Catalog Number: (10147-798)
Supplier: Corning
Description: The Falcon® HTS 96-multiwell insert system is a cell culture insert platform suitable for both manual and robotic screening of compounds in cell-based assays. The system has been tested for its ability to produce a differentiated monolayer of Caco-2, LLC-PK1, and MDCK cells making it an ideal platform for<i> in vitro</i> bioavailability and permeability studies. This automation compatible platform is composed of a 1.0 µm pore size PET membrane-based 96-multiwell insert plate, a media feeder tray and a lid. The drop-in baffle for the feeder tray mitigates media sloshing and lowers the risk of contamination.

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Product Image-10099-632

Anti-SCN1B Rabbit Polyclonal Antibody

Catalog Number: (10099-632)
Supplier: Prosci
Description: Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.Voltage-gated sodium channels are essential for the generation and propagation of action potentials in striated muscle and neuronal tissues. Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone can exhibit all the functional attributes of a voltage-gated Na+ channel, but requires a beta-1 subunit for normal inactivation kinetics.
Image Unavailable-CA80057-832

L(+)-Ascorbic acid free acid, Calbiochem®

Catalog Number: (CA80057-832)
Supplier: MilliporeSigma
Description: Protects cells against damaging effects of radiation and oxygen radicals. Increases rate of mineralization in osteoblasts. A cofactor involved in hydroxylation of proline and lysine. Reduces Na+-Ca2+ exchange in cultured astrocytes. Modulates cyclic nucleotide levels in B and T cells. Inhibits apoptosis in cultured rat ovarian follicles.

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Image Unavailable-89363-144

Anti-Aldosterone Mouse Monoclonal Antibody

Catalog Number: (89363-144)
Supplier: Genetex
Description: Aldosterone acts on the kidney promoting the reabsorption of sodium ions (Na+) into the blood. Water follows the salt and this helps maintain normal blood pressure. It also acts on sweat glands to reduce the loss of sodium in perspiration and taste cells to increase the sensitivity of the taste buds to sources of sodium.
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