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Catalog Number: (10348-556)
Supplier: Bioss
Description: OXSR1 is a serine/threonine kinase which regulates downstream kinases in response to environmental stress such as osmotic stresses, notably sorbitol and, to a lesser extent, NaCl. OXSR1 phosphorylated thr84 within the N-terminal regulatory domain of PAK1. Replacement of thr84 with gln reduced activation of PAK1 by an active form of the small G protein CDC42, suggesting that phosphorylation by OXSR1 modulates the G protein sensitivity of PAK. OXSR1 interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT. OXSR1 may have a role in regulating the actin cytoskeleton.


Supplier: VWR International
Description: The VWR® Advanced Melting Point Apparatus is used in determining the purity of a sample and is optimized to quickly and efficiently heat up to 3 samples at one time.

Environmentally Preferable Product available on GSA Advantage®

Catalog Number: (76333-862)
Supplier: Sper Scientific
Description: Fits standard test tubes 16×50 mm or larger.


Catalog Number: (76333-860)
Supplier: Sper Scientific
Description: Fits standard test tubes 16×50 mm or larger.


Catalog Number: (10393-368)
Supplier: Bioss
Description: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.


Supplier: WORLD PRECISION INSTRUMENTS LLC
Description: Replacement probe

New Product

Supplier: VWR International
Description: The VWR® Advanced Melting Point Apparatus is used in determining the purity of a sample and is optimized to quickly and efficiently heat up to 3 samples at one time.

Environmentally Preferable Product available on GSA Advantage®

Catalog Number: (77439-836)
Supplier: Bioss
Description: ATF6 is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. It binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. ATF6 could also be involved in activation of transcription by the serum response factor. ATF6 exists as a homodimer and heterodimer with ATF6 beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). It also interacts with the transcription factors GTF2I, YY1 and SRF. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. The basic domain of ATF6 functions as a nuclear localization signal and the basic leucine zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE. During the unfolded protein response an approximately 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site 1 and site 2 proteases. ATF6 is N glycosylated, phosphorylated in vitro by MAPK14/P38MAPK and belongs to the bZIP family.


Supplier: SP Industries
Description: These benchtop heating mantles are used for round bottom glass flasks.

Catalog Number: (10068-500)
Supplier: Prosci
Description: Involved in stress resistance and actin organization.


Catalog Number: (10032-020)
Supplier: YSI
Description: Single-junction pH electrode (gray replacement) replacement pH sensor


Catalog Number: (CAPIPA5-13537)
Supplier: Thermo Scientific
Description: CREB3L1 is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. It is specifically involved in ER-stress response in astrocytes in the central nervous system (By similartity). It may play a role in gliosis. In vitro, it binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE.


Supplier: Mettler Toledo
Description: The FiveEasy™ and FiveEasy Plus™ benchtop instruments provide high quality conductivity measurements with the simple click of a button. Compact in design, and featuring various data export capabilities, the FiveEasy™ series instruments are the perfect companion to get reliable measurement data.

Catalog Number: (10401-324)
Supplier: Bioss
Description: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity).


Catalog Number: (CA89508-376)
Supplier: Hach


Catalog Number: (76083-028)
Supplier: Bioss
Description: OXSR1 is a serine/threonine kinase which regulates downstream kinases in response to environmental stress such as osmotic stresses, notably sorbitol and, to a lesser extent, NaCl. OXSR1 phosphorylated thr84 within the N-terminal regulatory domain of PAK1. Replacement of thr84 with gln reduced activation of PAK1 by an active form of the small G protein CDC42, suggesting that phosphorylation by OXSR1 modulates the G protein sensitivity of PAK. OXSR1 interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT. OXSR1 may have a role in regulating the actin cytoskeleton.


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