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Catalog Number: (76083-784)
Supplier: Bioss
Description: MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress. Similar to RSK, MSK1 contains two kinase domains (N term and a C term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain.


Catalog Number: (63042-418)
Supplier: Excelta
Description: These are designed to form a consistent stand off and cut the lead to length on most popular radial lead components.

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Catalog Number: (10748-530)
Supplier: Prosci
Description: XBP-1 Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.


Catalog Number: (10102-718)
Supplier: Prosci
Description: CHFR is an E3 ubiquitin-protein ligase required to transiently arrest cells in early prophase when they are exposed to microtubule poisons. It acts in early prophase before chromosome condensation, when the centrosome moves apart from each other along the periphery of the nucleus. CHFR probably promotes the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress. This suggests that it may be involved in signaling the presence of mitotic stress caused by microtubule poisons.


Supplier: VWR International
Description: <p>The VWR® collection pH electrodes provide a wide-array of sensor options for any application requirement.</p>

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Supplier: WORLD PRECISION INSTRUMENTS LLC
Description: Replacement probe

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Catalog Number: (74950-334)
Supplier: Bel-Art Products, a Part of SP
Description: Housed in black anodized aluminum frame with tube-lock to prevent turning during locking. Metering tube won’t shift under pressure or vacuum. With Buna-N, 316 stainless steel and Delrin* valves with hose barbs for 8 to 9.5mm I.D. tubing, removable for female 3.2mm NPT fittings.


Supplier: Restek
Description: Metering gas valves are fabricated from nickel-plated brass or stainless steel.

Catalog Number: (10458-104)
Supplier: Bioss
Description: Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.


Supplier: VWR International
Description: Ultrasonic cleaners provide highly effective and efficient cleaning of laboratory glassware and instruments.
Catalog Number: (CA89508-364)
Supplier: Hach
Description: Hach Pocket Pro and Pro+ are engineered to deliver accurate results. Calibration functions for ongoing testing, diagnostics with select models and a stabilized sample lock ensure you get the right reading. You also get replaceable batteries for convenient field use, and a large, easy-to-read LCD screen.


Catalog Number: (10458-106)
Supplier: Bioss
Description: Acts as a stress-induced self-antigen that is recognized by gamma delta T-cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.


Catalog Number: (10353-272)
Supplier: Bioss
Description: GCN2 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor 2 to downregulate protein synthesis in response to varied cellular stresses.


Catalog Number: (10449-206)
Supplier: Bioss
Description: Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response (By similarity).


Catalog Number: (77440-660)
Supplier: Bioss
Description: Binds to GTP-bound form of Rho and to profilin. Acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. It is required for cytokinesis, stress fiber formation, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics.


Catalog Number: (76360-050)
Supplier: Antyila Scientific
Description: View, store, and share real-time data on your smartphone.


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