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Product Image-89150-766

HAT activator, CTPB ≥97% (by 1H-NMR)

Supplier: Enzo Life Sciences
Description: p300 HAT activator.

Product Image-89156-146

HAT Activity Assay Kit, Enzo Life Sciences

Catalog Number: (89156-146)
Supplier: Enzo Life Sciences
Description: Histone acetyltransferases (HATs) have been implicated to play a crucial role in various cellular functions, such as gene transcription, differentiation, and proliferation
Product Image-89358-028

Anti-KAT2A Rabbit Polyclonal Antibody

Catalog Number: (89358-028)
Supplier: Genetex
Description: KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM]
Image Unavailable-10094-372

Anti-SET Rabbit Polyclonal Antibody

Catalog Number: (10094-372)
Supplier: Proteintech
Description: SET, also named as IGAAD, I-2PP2A, TAF-I, IGAAD and PHAPII, belongs to the nucleosome assembly protein (NAP) family. It is a multitasking protein which involved in apoptosis, transcription, nucleosome assembly and histone binding. In the course of cytotoxic T-lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher. This antibody is specific to SET. It can recognize isoform1 and isoform2 of SET.
Image Unavailable-10093-846

Anti-ROCK2 Rabbit Polyclonal Antibody

Catalog Number: (10093-846)
Supplier: Proteintech
Description: ROCK2 is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element.It is an isozyme of ROCK1, is a target for the small GTPase Rho.ROCK2 is localized in the nucleus, associates with and phosphorylates p300, and increases its HAT activity in vitro.This antibody is specific to ROCK2.
Product Image-10105-534

Anti-MRGBP Rabbit Polyclonal Antibody

Catalog Number: (10105-534)
Supplier: Prosci
Description: C20orf20 is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair.
Image Unavailable-10663-934

Anti-USP22 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10663-934)
Supplier: Bioss
Description: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Image Unavailable-10663-940

Anti-USP22 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10663-940)
Supplier: Bioss
Description: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Image Unavailable-89359-224

Anti-HDAC1 Mouse Monoclonal Antibody [clone: HDAC1-21]

Catalog Number: (89359-224)
Supplier: Genetex
Description: Chromatin is composed of basic repeating units called nucleosomes, which are 146 bp of DNA wound around a histone octamer composed of two each of the core histones H2A, H2B, H3 and H4. Reversible acetylation of highly conserved lysine residues in N-terminal tail domains of core histones plays an important role in transcriptional regulation, cell cycle progression and developmental events. Several histone acetyltransferases (HATs) catalyze the acetylation reaction (GCN5, PCAF, p300/CBP, TAFII250, P/CAF, SRC-1 BRCA-2). Acetylation of the core histones is generally considered to be associated with gene activation, probably through maintenance of the unfolded structure of transcribing nucleosomes. Histone acetylation is a dynamic process whose levels are determined by the net activities of HATs and the competing enzymes histone deacetylases (HDACs). Both activities are associated with the nuclear matrix. Six or seven different mammalian HDACs have been described. HDACs are similar to the yeast Rpd3 protein, while HDACs are similar to the yeast Hda1 protein. Histone deacetylase activities are often, but not always, associated with transcriptional repression and nucleosomal condensations. HDAC1 and 2 are the catalytic subunits of different multiprotein regulatory complexes. The components of such complexes include: corepressors such as mSin3, N-CoR, SMRT, associated proteins such as SAP18, SAP30, RbAp46, RbAp48, c-Ski oncogenic protein, a protein involved in DNA methylation, and more.
Product Image-10090-356

Anti-MORF4L1 Rabbit Polyclonal Antibody

Catalog Number: (10090-356)
Supplier: Proteintech
Description: MORF4L1, also named as MRG15, belongs to the MRG family. It is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. It is also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. This antibody has no cross-reaction to MORF4L2.
Image Unavailable-10663-938

Anti-USP22 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10663-938)
Supplier: Bioss
Description: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Image Unavailable-76108-868

Anti-USP22 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76108-868)
Supplier: Bioss
Description: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Image Unavailable-10412-150

Anti-MORF4L1 Rabbit Polyclonal Antibody

Catalog Number: (10412-150)
Supplier: Bioss
Description: MRG15 ia a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair.
Image Unavailable-76108-866

Anti-USP22 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76108-866)
Supplier: Bioss
Description: Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Image Unavailable-10412-164

Anti-MORF4L1 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10412-164)
Supplier: Bioss
Description: MRG15 ia a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair.
Image Unavailable-10412-170

Anti-MORF4L1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10412-170)
Supplier: Bioss
Description: MRG15 ia a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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