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Anti-PMS1 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10663-422)
Supplier: Bioss
Description: The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
Product Image-CA89497-620

Letheen Broth, Modified, Hardy Diagnostics

Catalog Number: (CA89497-620)
Supplier: HARDY DIAGNOSTICS CA
Description: Letheen Broth, Modified, 16x125mm tube, 9ml fill, order by the package of 20, by Hardy Diagnostics.

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Image Unavailable-103010-660

SensoLyte® 520 Cathepsin E Assay Kit Fluorimetric, AnaSpec, Inc.

Catalog Number: (103010-660)
Supplier: Anaspec Inc
Description: Cathepsin E is a non-lysosomal aspartic proteinase of the pepsin superfamily, playing an important role in host defense against cancer cells in addition to it’s roles in protein degradation, antigen processing etc
Image Unavailable-75919-366

Anti-KRT18 Mouse Monoclonal Antibody (CF488A) [clone: DA7]

Supplier: Biotium
Description: Cytokeratin 18 Monoclonal antibody, Clone: DA7, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Human breast cancer PMC 42 cells, Synonyms: K18, Application: IF, IHC, WB, FC, Size: 100uL

Product Image-10110-558

Anti-RSRC2 Rabbit Polyclonal Antibody

Catalog Number: (10110-558)
Supplier: Prosci
Description: In vitro study revealed that RSRC2 might play a role in cell proliferation. RSRC2 may be a novel tumor suppressor of esophageal cancer cell growth.
Image Unavailable-75919-722

Anti-KRT19 Mouse Monoclonal Antibody (CF640R) [clone: KRT19/799 KRT19/800]

Supplier: Biotium
Description: Cytokeratin 19 Monoclonal antibody, Clone: KRT19/799 + KRT19/800, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF640R, Immunogen: Human breast cancer MCF-7 cells, Synonyms: k19, k1cs, krt19, Application: IF, Size: 100uL

Image Unavailable-76120-868

Anti-C3orf54 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76120-868)
Supplier: Bioss
Description: C3orf54 is a 285 amino acid protein encoded by a gene that maps to human chromosome 3p21.31. Chromosome 3 is made up of approximately 214 million bases encoding over 1100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
Image Unavailable-76109-714

Anti-IQCF1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76109-714)
Supplier: Bioss
Description: IQCF1 is an 81 amino acid protein encoded by the IQCF1 gene, which maps to human chromosome 3. Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
Image Unavailable-102980-110

Human Recombinant RANKL (Soluble) (from HEK293 Cells)

Supplier: Adipogen
Description: RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T cell proliferation. Important regulator of interactions between T cells and dendritic cells and may play a role in the regulation of the T cell-dependent immune response. RANKL plays an important role in the progression of breast cancer.

Image Unavailable-75977-704

Anti-TRIM29 Mouse Monoclonal Antibody [clone: TRIM29/1041]

Supplier: Biotium
Description: This antibody recognizes a 66 kDa protein, which is identified as Tripartite motif-containing protein 29 (TRIM29). It interacts with the intermediate filament protein vimentin, a substrate for the PKC family of protein kinases, and with hPKCI-1, an inhibitor of the PKCs. TRIM29 protein contains both zinc finger and leucine zipper motifs, suggesting that the it may form homodimers and possibly associate with DNA. High expression of TRIM29 has been reported in gastric cancer and pancreatic cancer, and correlates with enhanced tumor growth and lymph node metastasis. TRIM29 is also able to distinguish lung squamous cell carcinoma from lung adenocarcinoma with ~90% positive accuracy, when used in a panel with TTF-1, p63, CK5/6, and Napsin-A antibodies.

Image Unavailable-76083-404

Anti-Beta Catenin Ser675 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76083-404)
Supplier: Bioss
Description: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009].
Image Unavailable-76120-208

Anti-C3orf24 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76120-208)
Supplier: Bioss
Description: C3orf24, also known as MGC40179, is a 177 amino acid protein that is encoded by a gene that maps to human chromosome 3p25.3. Chromosome 3 is made up of approximately 214 million bases encoding over 1100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
Product Image-10750-906

Anti-DCAF12 Chicken Polyclonal Antibody

Catalog Number: (10750-906)
Supplier: Prosci
Description: TCC52 Antibody: Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors. One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time.
Image Unavailable-10094-640

Anti-SIDT1 Rabbit Polyclonal Antibody

Catalog Number: (10094-640)
Supplier: Proteintech
Description: SIDT1 belongs to the SID1 family. The study of IL-4/Stat6 pathway in breast cancer showed that SIDT1 is upregulated by IL4. This antibody is specific to SIDT1.
Image Unavailable-10486-776

Anti-NHLRC3 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10486-776)
Supplier: Bioss
Description: NHLRC3 contains 4 NHL repeats. The function of the NHLRC3 protein remains unknown. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
Image Unavailable-10486-782

Anti-NHLRC3 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10486-782)
Supplier: Bioss
Description: NHLRC3 contains 4 NHL repeats. The function of the NHLRC3 protein remains unknown. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumor suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival. Trisomy 13, also known as Patau syndrome, is quite deadly and the few who survive past one year suffer from permanent neurologic defects, difficulty eating and vulnerability to serious respiratory infections.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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