You Searched For: Fmoc-O-phospho-L-tyrosine

Catalog Number: (10068-518)

Supplier: Prosci

Description: Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.

Catalog Number: (89276-742)

Supplier: Genetex

Description: Rabbit polyclonal antibody to FLT3 (phospho Y591)

Catalog Number: (89366-902)

Supplier: Genetex

Description: Rabbit polyclonal antibody to Trk B (phospho Tyr515)

Catalog Number: (10791-922)

Supplier: Genetex

Description: Rabbit Polyclonal antibody to ALK (phospho Tyr1604)

Catalog Number: (76077-242)

Supplier: Bioss

Description: The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.

Catalog Number: (10813-750)

Supplier: Prosci

Description: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Catalog Number: (10352-960)

Supplier: Bioss

Description: The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]

Catalog Number: (10413-414)

Supplier: Bioss

Description: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.

Catalog Number: (10794-198)

Supplier: Genetex

Description: Rabbit polyclonal antibody to Vinculin (phospho Tyr1065)

Catalog Number: (76080-202)

Supplier: Bioss

Description: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.

Catalog Number: (89304-268)

Supplier: Genetex

Description: Rabbit Polyclonal antibody to TYK2 (Phospho Tyr1054)

Catalog Number: (89304-024)

Supplier: Genetex

Description: Rabbit monoclonal antibody [T.602.6] to FLT3 (phospho Tyr969)

Catalog Number: (89304-122)

Supplier: Genetex

Description: Rabbit Polyclonal antibody to FAK (Phospho Tyr861)

Catalog Number: (89276-452)

Supplier: Genetex

Description: Rabbit polyclonal antibody to TrkB (phospho Y705)

Catalog Number: (89276-512)

Supplier: Genetex

Description: Rabbit polyclonal antibody to Pyk2 (phospho Y402)

Catalog Number: (89304-524)

Supplier: Genetex

Description: Rabbit Polyclonal antibody to TrkB (Phospho Tyr515)