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Catalog Number: (10471-308)
Supplier: Bioss
Description: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.


Catalog Number: (10068-794)
Supplier: Prosci
Description: GATA1 encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.


Catalog Number: (77664-188)
Supplier: WORLD PRECISION INSTRUMENTS LLC
Description: The D4H is a combined deuterium and halogen light source for UV/VIS and NIR applications. This light source is ideally suited to work with WPI’s spectrometer modules and sample cells. It supplies a continuous spectrum in the UV, VIS and NIR range from 200 to 1100 nm. The D4H is equipped with an integrated electrical shutter, which can be controlled by a switch or a TTL signal.

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Supplier: FUJIFILM IRVINE SCIENTIFIC, INC
Description: Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.

Catalog Number: (77437-284)
Supplier: Bioss
Description: Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene. Gamma-enolase is a phosphopyruvate hydratase. Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.


Catalog Number: (10110-968)
Supplier: Prosci
Description: PRKAA1 belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways.The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.


Supplier: Brady Worldwide
Description: Raised panel Adhesive-Taped Polyester (B-593) labels are designed for patch panel identification, external push-buttons, switches, and internal connection points.

Catalog Number: (33797-440)
Supplier: Glas-Col
Description: For precise manual control of heating tapes, cords, and mantles

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Supplier: New England Biolabs (NEB)
Description: The NEBNext Single Cell/Low Input cDNA Synthesis and Amplification Module uses a template switching method to generate full length cDNAs directly from single cells or 2 pg to 200 ng RNA.

Catalog Number: (75794-214)
Supplier: Prosci
Description: CD40 is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 contains 4 cysteine-rich repeats in the extracellular domain and is expressed in B cells, dendritic cells, macrophages, endothelial cells and several tumor cell lines. The cognate interaction between CD40 and CD40 ligand (CD154) on T cells activates NF-kappaB, Jun N-terminal kinase and Janus kinase signal transducers and activators of transcription pathways. Several different TRAF proteins (adapter proteins) have been identified to serve as mediators of the signal transduction. In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation and thus is thought to be an early event in Alzheimer disease pathogenesis. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterized by the inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response and a lack of germinal center formation.


Catalog Number: (10088-272)
Supplier: Proteintech
Description: Histone H2A.X belongs to the histone H2A family, which is synthesized in G1 and S phase. It is involved in nucleosomal organization of chromatin together with other histone proteins, and is specially important for recombination between immunoglobulin switch regions. H2A.X becomes phosphorylated on serine 139 (to form gamma-H2AFX or H2AX139ph) in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks, which promotes DNA repair and maintains genomic stability.


Catalog Number: (76085-224)
Supplier: Bioss
Description: Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.


Catalog Number: (10084-482)
Supplier: Proteintech
Description: Cdc42, the human homologue of the cell division cycle 42 of Saccharomyces cerevisiae, belongs to the Rho/Rac subfamily of Ras-like GTPases. It acts as molecular switches to regulate numerous cellular responses including the organization of the actin cytoskeleton, gene transcription, cell cycle progression, and membrane trafficking. The molecular weight is about 21 kd.


Catalog Number: (76235-904)
Supplier: Rockland Immunochemical
Description: Rat MIP-1 alpha - CCL3 AccuSignal ELISA Kit


Catalog Number: (97002-472)
Supplier: Labconco
Description: Provides A Hands-Free Means To Shut Off Power To The Built-In Blower.

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Catalog Number: (56612-270)
Supplier: EMI - Emergency Medical International
Description: Quality, rugged, and affordable penlight.


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