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Image Unavailable-10465-472

Anti-DSTYK Rabbit Polyclonal Antibody (Cy5.5®)

Description: The RIPK5 gene encodes a dual serine/threonine and tyrosine protein kinase that is expressed in multiple tissues. Multiple alternatively spliced transcript variants have been found, but the biological validity of some variants has not been determined.
Catalog Number: 10465-472
Supplier: Bioss
Image Unavailable-75791-692

Mouse Recombinant ALK1

Description: Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF- beta superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.
Catalog Number: 75791-692
Supplier: Prosci
Image Unavailable-10465-478

Anti-DSTYK Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Description: The RIPK5 gene encodes a dual serine/threonine and tyrosine protein kinase that is expressed in multiple tissues. Multiple alternatively spliced transcript variants have been found, but the biological validity of some variants has not been determined.
Catalog Number: 10465-478
Supplier: Bioss
Image Unavailable-89360-154

Anti-RIPK3 Mouse Monoclonal Antibody [clone: Rippy-3]

Description: Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Over expression of RIP3 induces apoptosis and NF-kB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.
Catalog Number: 89360-154
Supplier: Genetex
Product Image-CA101641-528

Casein Kinase II

Description: Casein Kinase II (CK2) is a constitutively active serine/threonine protein kinase composed of two 44 kDa catalytic α-subunits and two 26 kDa regulatory β-subunits in an α2β2 configuration to form stable heterotetramers
Catalog Number: CA101641-528
Supplier: New England Biolabs (NEB)
Image Unavailable-10420-954

Anti-ROCK2 Rabbit Polyclonal Antibody

Description: The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
Catalog Number: 10420-954
Supplier: Bioss
Image Unavailable-10420-950

Anti-ROCK2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Description: The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
Catalog Number: 10420-950
Supplier: Bioss
Product Image-10103-216

Anti-GALNT5 Rabbit Polyclonal Antibody

Description: GALNT5 can catalyze the initial reaction in O-linked oligosaccharide biosynthesis,the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. GALNT5 has activity toward EA2 peptide substrate, but it has a weak activity toward Muc2 or Muc1b substrates.
Catalog Number: 10103-216
Supplier: Prosci
Image Unavailable-103005-904

DNA-PK Substrate

Description: A substrate for DNA-dependent protein kinase (DNA-PK), phosphorylation. DNA-PK is essential for the repair of DNA double-strand breaks. This peptide corresponding to 11–24 amino acids of human p53 with threonine 18 and serine 20 changed to alanine is used as a substrate for the assay of DNA-PK activity
Sequence:EPPLSQEAFADLWKK
MW:1759 Da
% peak area by HPLC:95
Storage condition:-20° C
Catalog Number: 103005-904
Supplier: Anaspec Inc
Image Unavailable-76119-980

Anti-CLK3 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Description: Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates serines, threonines and tyrosines.
Catalog Number: 76119-980
Supplier: Bioss
Image Unavailable-76082-820

Anti-LIMK1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Description: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes. Required for atypical chemokine receptor ACKR2-induced phosphorylation of cofilin (CFL1).
Catalog Number: 76082-820
Supplier: Bioss
Image Unavailable-76082-200

Anti-MEK6 Ser207 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Description: Mitogen activated protein kinase kinase 6 (MEK6 or MKK6) belongs to the serine/threonine protein kinase family and the MAPK kinase subfamily (MAP2K, MKK or MEKs). MEK6, closely related to MEK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38, thus activating it, in response to inflammatory cytokines and environmental stress.As an essential component of p38 MAP kinase mediated signal transduction pathway, this protein is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
Catalog Number: 76082-200
Supplier: Bioss
Image Unavailable-CAPIPA5-18658

Anti-OGT Goat Polyclonal Antibody

Description: This antibody is predicted to react with canine and human based on sequence homology. This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Catalog Number: CAPIPA5-18658
Supplier: Thermo Scientific
Image Unavailable-89320-448

Anti-SIK Rabbit Polyclonal Antibody

Description: Rabbit Polyclonal antibody to PAK3 (serine/threonine-protein kinase PAK 3)
Catalog Number: 89320-448
Supplier: Genetex
Image Unavailable-89321-134

Anti-CAMK2A Rabbit Polyclonal Antibody

Description: Rabbit Polyclonal antibody to Chk2 (serine/threonine-protein kinase Chk2)
Catalog Number: 89321-134
Supplier: Genetex
Image Unavailable-10417-338

Anti-PDPK1 Rabbit Polyclonal Antibody (Cy5.5®)

Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.
Catalog Number: 10417-338
Supplier: Bioss
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