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Image Unavailable-77436-646

Anti-GGCX Rabbit Polyclonal Antibody

Catalog Number: (77436-646)
Supplier: Bioss
Description: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.
Image Unavailable-76100-728

Anti-CIB1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76100-728)
Supplier: Bioss
Description: CIB1(Calcium and integrin binding 1) may convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through the binding to the integrin cytoplasmic domain.
Image Unavailable-10491-064

Anti-ORAI2 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10491-064)
Supplier: Bioss
Description: Orai2 is a 254 amino acid multi-pass membrane protein that belongs to the orai family of proteins. Localizing to the plasma membrane, Orai2 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. CRAC channels are responsible for medi-ating calcium influx in T-cells and play an important role in the immune response. Orai2 specifically increases the Ca2+-selective current through coaction with the Ca2+ sensor Stim1.
Image Unavailable-10491-062

Anti-ORAI2 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10491-062)
Supplier: Bioss
Description: Orai2 is a 254 amino acid multi-pass membrane protein that belongs to the orai family of proteins. Localizing to the plasma membrane, Orai2 plays an important role in store-operated calcium (SOC) entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. CRAC channels are responsible for medi-ating calcium influx in T-cells and play an important role in the immune response. Orai2 specifically increases the Ca2+-selective current through coaction with the Ca2+ sensor Stim1.
Image Unavailable-10417-048

Anti-NFATc2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10417-048)
Supplier: Bioss
Description: Nuclear factor of activated T cells (NFAT) is a family of transcription factors implicated in multiple biological processes including cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. NFAT1 (also known as NFATc2 or NFATp) is a member of this family that is regulated by the calcium-dependent phosphatase calcineurin. When calcineurin is activated by calcium it dephosphorylates multiple residues in the regulatory domain of NFAT1, leading to its translocation to the nucleus and activation of its transcriptional activity. Once in the nucleus, NFAT proteins act synergistically with the AP-1 transcription factor complex to regulate the expression of multiple genes. Serine 54 in mouse NFAT1 has been shown to be important in the regulation of its transcriptional activity.
Product Image-10408-622

Anti-SIGMAR1 Rabbit Polyclonal Antibody

Catalog Number: (10408-622)
Supplier: Bioss
Description: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration.
Image Unavailable-H-6544.1000BA

Human Met-RANTES Trifluoroacetate

Supplier: Bachem Americas
Description: Synthetic product. Potent antagonist of RANTES and macrophage inflammatory polypeptide-1α (MIP-1α). Met-RANTES inhibited RANTES- or MIP-1α-induced chemotaxis of promonocytic THP-1cells and T-cells. Although Met-RANTES antagonized RANTES and MIP-1α with similar potency in the chemotaxis response it showed a clear difference in the cytokine-induced calcium mobilization assay.

SDS

Image Unavailable-77436-700

Anti-DSPP Rabbit Polyclonal Antibody

Catalog Number: (77436-700)
Supplier: Bioss
Description: DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
Image Unavailable-10336-766

Anti-ATP2c1/2 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10336-766)
Supplier: Bioss
Description: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.
Image Unavailable-76082-600

Anti-NFATc2 Ser326 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76082-600)
Supplier: Bioss
Description: Nuclear factor of activated T cells (NFAT) is a family of transcription factors implicated in multiple biological processes including cytokine gene expression, cardiac hypertrophy and adipocyte differentiation. NFAT1 (also known as NFATc2 or NFATp) is a member of this family that is regulated by the calcium-dependent phosphatase calcineurin. When calcineurin is activated by calcium it dephosphorylates multiple residues in the regulatory domain of NFAT1, leading to its translocation to the nucleus and activation of its transcriptional activity. Once in the nucleus, NFAT proteins act synergistically with the AP-1 transcription factor complex to regulate the expression of multiple genes. Serine 54 in mouse NFAT1 has been shown to be important in the regulation of its transcriptional activity.
Image Unavailable-10413-966

Anti-GABBR2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10413-966)
Supplier: Bioss
Description: Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
Image Unavailable-10339-488

Anti-BDKRB2 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10339-488)
Supplier: Bioss
Description: Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Image Unavailable-75789-458

Human Recombinant CADM3 (from Cells)

Catalog Number: (75789-458)
Supplier: Prosci
Description: Cell Adhesion Molecular Proteins are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix in the cell adhesion process. These proteins consists of three domains, an transmembrane domain, an intracellular domain that interacts with the cytoskeleton, and an extracellular domain that interacts with other CAMs of the same kind or with other CAMs or the extracellular matrix. Cell Adhesion Molecular 3 (CADM3) is a neural tissue-specific member of the nectin-like family of immunoglobulin superfamily. CADM3 interacts with EPB41L1 may regulate structure or function of cell-cell junctions. CADM3 has both calcium-independent homophilic cell-cell adhesion activity and calcium-independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3.
Image Unavailable-10419-070

Anti-PRKCZ Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10419-070)
Supplier: Bioss
Description: Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
Product Image-10101-250

Anti-CACNB2 Rabbit Polyclonal Antibody

Catalog Number: (10101-250)
Supplier: Prosci
Description: CACNB2 is a subunit of voltage-dependent calcium (Ca2+) channels, expressed in the CNS. It appears to serve an obligatory function.
Image Unavailable-76079-340

Anti-Annexin A7 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76079-340)
Supplier: Bioss
Description: The Annexins are a family of structurally similar proteins. Annexins bind to phospholipids and may be involved in regulation of membrane transport, membrane channel activity, and interaction of the cell membrane with the extracellular matrix. Annexin A7 is a member of the annexin family of calcium dependent phospholipid binding proteins. The Annexin A7 gene contains 14 exons and spans approximately 34 kb of DNA. Structural analysis of the protein suggests that Annexin A7 is a membrane binding protein with diverse properties including voltage sensitive calcium channel activity, ion selectivity and membrane fusion.
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