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Anti-TYR Mouse Monoclonal Antibody (CF405S) [clone: T311 OCA1/812]

Supplier: Biotium
Description: This antibody recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Image Unavailable-75978-666

Anti-TYR Mouse Monoclonal Antibody (CF405S) [clone: OCA1/812]

Supplier: Biotium
Description: This antibody recognizes a cluster of proteins between 70-80 kDa, identified as tyrosinase. Occasionally a minor band at 55 kDa is also detected. This MAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this MAb shows tyrosinase in melanotic as well as amelanotic variants. This MAb is a useful marker for melanocytes and melanomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Image-76379-720

Heracell i CO₂ Incubators with Variable O₂ Control, Thermo Scientific

Supplier: Thermo Fisher Scientific
Description: Heracell i CO₂ incubators with variable control of oxygen stimulate cell behaviors that are more predictive of the <i>in vivo</i> environment. Available in a choice of two ranges of O₂ control, 1 to 21% for physiological levels and 5 to 90% for hyperoxic studies.each is supplied with maintenance free zirconia oxide sensor is calibrated automatically and remains in place during the ContraCon high temperature decontamination, and a unique gas tight segmented inner door assembly enables access sections of the chamber without disturbing the entire environment to minimize recovery time, contamination risk, and gas consumption.

CSA Certified Product available on GSA Advantage®

Image Unavailable-103357-974

Anti-SLC31A1/CTR1 Rabbit Polyclonal Antibody (Alexa Fluor® 647)

Catalog Number: (103357-974)
Supplier: Novus Biologicals
Description: The SLC31A1 / CTR1 Antibody [Alexa Fluor« 647] from Novus Biologicals is a rabbit polyclonal antibody to SLC31A1 / CTR1. This antibody reacts with human, mouse, rat, porcine, xenopus, zebrafish. The SLC31A1 / CTR1 Antibody [Alexa Fluor« 647] has been validated for the following applications: Western Blot, Immunocytochemistry / Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.
Image Unavailable-75881-406

Anti-AFP Mouse Monoclonal Antibody (CF647) [clone: MBS-12]

Supplier: Biotium
Description: This antibody recognizes an oncofetal glycoprotein with a single chain of 70 kDa, which is identified as alpha fetoprotein (AFP). This MAb is highly specific to AFP and shows no cross-reaction with other oncofetal antigens or serum albumin. The yolk sac and the liver produce AFP during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the AFP and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. AFP is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spinal bifida and anencephaly.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

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Aluminium ammonium sulfate dodecahydrate, REacton®, Reagent Grade

Supplier: Thermo Scientific Chemicals
Description: Water and sewage purification, dyeing and printing fabrics, manufacturing of pigments, paper, artificial gems, cements, in electrolytic copper plating

Certificates

Product Image-CA14223-574

Orion™ Powder Chemistry Packs, Thermo Scientific

Supplier: Thermo Fisher Scientific
Description: Orion™ AQUAfast Powder Pack Reagents perform colorimetric measurements of common water parameters with powders that dissolve quickly and mix easily.

Image Unavailable-75883-872

Anti-AFP Mouse Monoclonal Antibody (CF405S) [clone: MBS-12]

Supplier: Biotium
Description: This antibody recognizes an oncofetal glycoprotein with a single chain of 70 kDa, which is identified as alpha fetoprotein (AFP). This MAb is highly specific to AFP and shows no cross-reaction with other oncofetal antigens or serum albumin. The yolk sac and the liver produce AFP during fetal life. AFP expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the AFP and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. AFP is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of AFP in amniotic fluid is used to measure renal loss of protein to screen for spinal bifida and anencephaly.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Image Unavailable-75789-852

Human Recombinant S100 calcium binding A12 (from E. coli)

Catalog Number: (75789-852)
Supplier: Prosci
Description: Human EN-RAGE belongs to the S100/calgranulin superfamily. There are at least 21 different S100 proteins and the protein is 100% soluble in ammonium sulfate at neutral pH. S100 proteins play a role in regulation of protein phosphorylation, transcription factors, the dynamics of cytoskeleton constituents, enzyme activities, cell growth and differentiation, and the inflammatory response.Human EN-RAGE is characterized by two EF-hand calcium-binding motifs, zinc- and copper-binding protein.S100A12 is a disulfide-linked homodimer and the interface between the two subunits is composed mostly of hydrophobic residues.Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. EN-RAGE acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. It also acts as a monocyte and mast cell chemoattractant. Moreover, it can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. It can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+from their active sites.
Product Image-CAPI23234

Pierce™ Micro BCA™ Protein Assay Kit and Reagents, Thermo Scientific

Catalog Number: (CAPI23234)
Supplier: Thermo Scientific
Description: The Micro BCA Protein Assay Kit is a specialized version of the popular Pierce BCA Protein Assay for determining the protein concentration of dilute samples.

SDS Certificates


Product Image-BDH7466-1

Sodium chloride 0.85% (w/v), VWR Chemicals BDH®

Catalog Number: (BDH7466-1)
Supplier: VWR International
Description: Made with purified water and ACS grade sodium chloride.

SDS Certificates


Product Image-CA89167-794

Bicinchoninic Acid (BCA) Protein Assay, G-Biosciences

Supplier: G-Biosciences
Description: The Bicinchoninic Acid (BCA) protein assay is a highly sensitive colorimetric assay that is compatible with detergent solubilized protein solutions

SDS

Product Image-BDH7899-1

Magnesium chloride 51% (w/v) in aqueous solution, Reagent Grade analytical reagent, VWR Chemicals BDH®

Catalog Number: (BDH7899-1)
Supplier: VWR International
Description: Made with deionized water.

SDS Certificates


Product Image-BDH7296-0

Potassium chloride 3.0 M in aqueous solution analytical reagent, VWR Chemicals BDH®

Catalog Number: (BDH7296-0)
Supplier: VWR International
Description: Made with deionized water.

SDS Certificates


Product Image-BDH7257-1

Sodium chloride solution 0.90% (w/v) in water, VWR Chemicals BDH®

Supplier: VWR International
Description: Made with deionized water

SDS Certificates Product available on GSA Advantage®

Product Image-BDH7965-2

Potassium chloride 4.0 M saturated with silver chloride aqueous solution analytical reagent, VWR Chemicals BDH®

Catalog Number: (BDH7965-2)
Supplier: VWR International
Description: Made with deionized water and saturated with <0.01% AgCl.

SDS Certificates


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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