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Product Image-470015-184

Simulated ABO and Rh Blood Typing Lab Activity

Supplier: Avantor
Description: Using Ward's safe and nontoxic simulated blood, students can simulate a blood-typing experiment and delve into the concepts of Rh typing.

Product Image-77752-100

Mouse Recombinant IL-2 (from E. coli)

Supplier: VWR International
Description: Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.

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Ward's® Soil-water medium

Catalog Number: (470180-754)
Supplier: Avantor
Description: For Culture of Freshwater Forms
Product Image-77750-048

Human Recombinant M-CSF (from E. coli)

Supplier: VWR International
Description: <p>Macrophage colony stimulating factor (M-CSF) is a hematopoietic growth factor that is widely produced by a variety of cells. M-CSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types. M-CSF also acts through the colony stimulating factor 1 receptor (CSF1R) to modulate processes involved in immunology, bone metabolism, fertility, and pregnancy. Human M-CSF shows activity on mouse cells; however, mouse M-CSF shows no activity on human cells.</p>

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Product Image-77752-518

Mouse Recombinant IL-17E (from E. coli)

Supplier: VWR International
Description: Interleukin 17E (IL-17E), also known as IL-25, is a member of the IL-17 family of cytokines. IL-17E binds to the IL-17RB receptor to stimulate the secretion of the proinflammatory interleukin 8 (IL-8) chemokine and to induce the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB).

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Product Image-77751-616

Human Recombinant OSM (from E. coli)

Supplier: VWR International
Description: Oncostatin M is a cytokine that is produced by macrophages, dendritic cells, and T lymphocytes during inflammatory events. The Type-I and Type-II Oncostatin M receptors are located on the cell surface of endothelial and tumor cells, contain the glycoprotein 130 (gp130) subunit, and activate the JAK/STAT signaling pathway.

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Product Image-470220-214

Forensic Dental Analysis

Supplier: Ward's Science
Description: Introduce Students to the Various Techniques Used in Forensic Dentistry

Product Image-470006-858

Magnets Student Study Kit

Catalog Number: (470006-858)
Supplier: Avantor
Description: Three simple, hands-on activities, geared towards young students, introduce the properties of magnets.
Product Image-77750-334

Human Recombinant MIP-3 B CCL19 (from E. coli)

Supplier: VWR International
Description: <p>Macrophage inflammatory protein-3 beta (MIP-3 β), also called CCL19, is a chemokine that is expressed in the thymus, lymph nodes, and activated bone marrow stromal cells. MIP-3 β signals through the G protein-coupled receptor CCR7 to regulate normal lymphocyte recirculation. MIP-3 β also functions during T cell trafficking to the thymus, and in T cell and B cell homing to the lymph nodes and secondary lymphoid organs. Human MIP-3 β shows activity on mouse cells.</p>

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Product Image-77751-976

Mouse Recombinant M-CSF (from E. coli)

Supplier: VWR International
Description: Macrophage colony stimulating factor (M-CSF) is a hematopoietic growth factor that is widely produced by a variety of cells. M-CSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types.  M-CSF also acts through the colony stimulating factor 1 receptor (CSF1R) to modulate processes involved in immunology, bone metabolism, fertility, and pregnancy.  Human M-CSF shows activity on mouse cells; however, mouse M-CSF shows no activity on human cells.  

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Product Image-77751-678

Human Recombinant G-CSF (from E. coli)

Supplier: VWR International
Description: Granulocyte-colony stimulating factor (G-CSF) is a cytokine that functions as a potent inducer of neutrophilic granulocyte proliferation, terminal differentiation, and activation. G-CSF synthesis occurs in monocyte, macrophage, epithelial, endothelial, and fibroblast cells after activation by bacterial endotoxins, tumor necrosis factor alpha (TNF-α), interleukin 1 (IL-1), or interleukin 17 (IL-17).

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Product Image-77751-962

Mouse Recombinant M-CSF (from E. coli)

Supplier: VWR International
Description: Macrophage colony stimulating factor (M-CSF) is a hematopoietic growth factor that is widely produced by a variety of cells. M-CSF stimulates the proliferation and differentiation of hematopoietic stem cells into monocyte and macrophage cell types.  M-CSF also acts through the colony stimulating factor 1 receptor (CSF1R) to modulate processes involved in immunology, bone metabolism, fertility, and pregnancy.  Human M-CSF shows activity on mouse cells; however, mouse M-CSF shows no activity on human cells.  

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Product Image-77751-208

Human Recombinant BAFF (from E. coli)

Supplier: VWR International
Description: <p>B cell-activating factor (BAFF), or B lymphocyte stimulator (BLyS), is a type II member of the tumor necrosis factor (TNF) superfamily. BAFF is expressed as a transmembrane protein on T cells, macrophages, and dendritic cells. The transmembrane domain of BAFF can also be cleaved to produce a soluble protein fragment. BAFF binds to the TNF receptors known as B cell maturation antigen (BCMA), transmembrane activator and CAML interactor (TACI), and BAFF receptor (BAFFR). BAFF is important for the survival and maturation of peripheral B cells. Human BAFF shows activity on mouse splenocytes.</p>

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Product Image-77753-404

Human Recombinant EGF (from E. coli)

Supplier: VWR International
Description: Epidermal Growth Factor (EGF) exerts its effects by binding to the EGF Receptor, a protein kinase that initiates the intracellular signaling (1). EGF is widely distributed in tissues like the kidney, cerebrum, prostate, and salivary glands. EGF acts as a potent factor in promoting cell division, and the phosphorylated receptor recruit adapter proteins like GRB2, which then activate complex downstream signaling cascades. EGF stimulates the proliferation differentiation, and survival of epithelial and epidermal cells. EGF possesses three intramolecular disulfide bonds and forms a strong attachment to the epidermal growth factor receptor (EGFR). Activation of EGFR initiates diverse cellular pathways in response to toxic environmental stimuli, or to EGF binding to the receptor, the EGFR forms homo- or heterodimers with other family members. (2, 3). EGF activates at least four major downstream signaling pathways, including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLC gamma-PKC, and STAT modules. Additionally, research suggests that EGF may play a significant role in activating the NF-kappa-B signaling cascade (4). Mutations in the EGF gene are responsible for hypomagnesemia type 4, and its dysregulation has been linked to the development and progression of certain cancers (5).

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Product Image-77750-072

Human Recombinant SCF (from E. coli)

Supplier: VWR International
Description: Stem cell factor (SCF) is a cytokine made by fibroblasts and endothelial cells. SCF binds to the receptor c-Kit/CD117 and plays a critical role in the maintenance, survival, and differentiation of hematopoietic stem cells. While human SCF shows no activity on murine cells, murine and rat SCF are active on human cells.

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Product Image-77751-088

Human Recombinant TGF-A (from E. coli)

Supplier: VWR International
Description: Tumor growth factor alpha (TGF-α) is a member of the epidermal growth factor (EGF) family. TGF-α function is mediated through binding the EGF receptor (EGFR) to activate receptor tyrosine kinase signaling. TGF-α functions as a mitogen to activate epithelial cell proliferation, growth, and differentiation. In the gastric mucosa, TGF-α production inhibits gastric acid secretion and therefore plays a central role in the pathogenesis of the stomach syndrome Ménétrier's disease. TGF-α is also produced in adult macrophages, brain cells, keratinocytes, and is widely expressed in cancer cells.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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