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Catalog Number: (10068-872)
Supplier: Prosci
Description: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.


Catalog Number: (10073-126)
Supplier: Prosci
Description: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway (1). MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor (2,3), which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.


Supplier: Enzo Life Sciences
Description: Ultra-pure; inhibits actin polymerization

Catalog Number: (10068-874)
Supplier: Prosci
Description: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.


Catalog Number: (CA351802-BL)
Supplier: Biolegend
Description: Purified anti-human CD221 (IGF-1R) [1H7/CD221]; Isotype: Mouse IgG1, κ; Reactivity: Human, African Green, Baboon, Cynomolgus, Rhesus; Apps: FC, IHC, IP, WB; Size: 100 μg


Catalog Number: (CA10759-310)
Supplier: Biolegend
Description: Purified anti-mouse CD115 (CSF-1R) (MaxPar® Ready) [AFS98]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC, CyTOF®; Size: 100 μg


Catalog Number: (76236-648)
Supplier: Rockland Immunochemical
Description: Human IL1R1 AccuSignal ELISA Kit


Supplier: Thermo Scientific Chemicals
Description: Resolving agent for carboxylic acids
Catalog Number: (TCD2520-001G)
Supplier: TCI America
Description: CAS Number: 121788-73-6
MDL Number: MFCD01321158
Molecular Formula: C16H14F6N2O4S2
Molecular Weight: 476.41
Purity/Analysis Method: >98.0% (GC)
Form: Crystal
Melting point (°C): 213
Specific rotation [a]20/D: 6 deg (C=1, CHCl3)

SDS


Supplier: Thermo Scientific Chemicals
Description: trans-4-Cyanocyclohexylamine hydrochloride, 97%
Catalog Number: (89415-366)
Supplier: Prosci
Description: IRAK-2 Antibody: The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-kappa B, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-kappa B activation. IRAKs also associate with Toll-like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kappa B activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory responses to cytokine IL-1 and LPS. IRAK2 is expressed in a variety of human tissues.


Supplier: Thermo Scientific Chemicals
Description: Potent inhibitor of protein synthesis in bacteria
Supplier: Enzo Life Sciences
Description: Immunosuppressant.

Catalog Number: (CA10759-304)
Supplier: Biolegend
Description: Brilliant Violet 711™ anti-mouse CD115 (CSF-1R) [AFS98]; Isotype: Rat IgG2a, κ; Reactivity: Mouse; Apps: FC; Size: 50 μg


Catalog Number: (10070-930)
Supplier: Prosci
Description: This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1.


Supplier: TCI America
Description: Genipin, Purity: >97.0%(GC), CAS number: 6902-77-8, Molecular Formula: C11H14O5, MW: 226.23, Synonym: Methyl (1S,2R,6S)-2-Hydroxy-9-(hydroxymethyl)-3-oxabicyclo[4.3.0]nona-4,8-diene-5-carboxylate, Physical state: Solid, Form: Crystal- Powder, Colour: White - Almost white, Size: 25MG
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