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Description: CLAMP SANITARY 1 1/2
Catalog Number: 102972-596
Supplier: Biotage


Description: CLAMP 10MM
Catalog Number: 77664-588
Supplier: WORLD PRECISION INSTRUMENTS LLC

New Product


Description: CLAMP PK2
Catalog Number: 103787-844
Supplier: Glass Expansion Inc


Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Acts as a RNA-dependent RNA polymerase when associated with small delta antigen of Hepatitis delta virus, acting both as a replicate and transcriptase for the viral RNA circular genome.
Catalog Number: 76117-306
Supplier: Bioss


Description: CLAMP SS HINGE 4
Catalog Number: 89009-376
Supplier: Rubber Fab


Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing. Regulation of gene expression levels depends on the balance between methylation and acetylation levels of tha CTD-lysines (By similarity). Initiation or early elongation steps of transcription of growth-factors-induced immediate early genes are regulated by the acetylation status of the CTD (PubMed:24207025). Methylation and dimethylation have a repressive effect on target genes expression
Catalog Number: 77437-594
Supplier: Bioss


Description: SAN CLAMP NYLON 3 IN
Catalog Number: MFLX95804-32
Supplier: ST. GOBAIN - TAUNTON


Description: CLAMP SS HINGE 3
Catalog Number: 89009-374
Supplier: Rubber Fab


Description: CLAMP THERMOCOUPLE 3PORTS 2
Catalog Number: 89009-416
Supplier: Rubber Fab


Description: CLAMP FOR 5L FLASK
Catalog Number: 76498-948
Supplier: Thermo Fisher Scientific


Description: FIXING CLAMP 60X220X39MM
Catalog Number: 77665-758
Supplier: WORLD PRECISION INSTRUMENTS LLC

New Product


Description: TUBE CLAMPS PK2
Catalog Number: CA56221-390
Supplier: 3M


Description: FERRULE 1/4" CLAMP SIZEX1/4"
Catalog Number: MFLX00170-MS
Supplier: ANDON SPECIALTIES INC.


Description: CLAMP 3-PRONG REPLACEMENT
Catalog Number: 89029-564
Supplier: Chemglass


Description: CLAMP THERMOCOUPLE 4PORTS 2
Catalog Number: 89009-418
Supplier: Rubber Fab


Description: CLAMP THERMOCOUPLE 2PORTS 4
Catalog Number: 89009-430
Supplier: Rubber Fab


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