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Image Unavailable-75843-188

Anti-CD178 Mouse Monoclonal Antibody (Biotin) [clone: NOK-1]

Catalog Number: (75843-188)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The NOK-1 monoclonal antibody specifically reacts with human CD178, which is the CD95 or Fas ligand. CD178 is a TNF superfamily type II transmembrane glycoprotein expressed by activated T and NK cells and is involved in Fas-mediated apoptosis of lymphocytes. CD178 is also expressed by monocytes, neutrophils, granulocytes and the parenchymal cells of the retina and cornea. The NOK-1 antibody has been reported to bind to COOH-terminus of the Fas ligand in the region associated with Fas binding.
Image Unavailable-75842-924

Anti-CD4 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: OKT4]

Catalog Number: (75842-924)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
Image Unavailable-75842-926

Anti-CD4 Mouse Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: OKT4]

Catalog Number: (75842-926)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
Image Unavailable-75843-236

Anti-TLR2 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: TL2.1]

Catalog Number: (75843-236)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The TL2.1 monoclonal antibody specifically reacts with human CD282, the Toll-like receptor 2 (TLR2). It is a type I transmembrane signaling receptor containing IL-1 receptor like intracellular domain and leucine-rich repeats (LRR) in the extracellular domain. CD282 is expressed on peripheral blood monocytes and is involved distinguishing bacterial lipoproteins. The TL2.1 antibody blocks the receptor and immunoprecipitates TLR2 from human mammary epithelial cells (HMEC) and peripheral blood mononuclear cells (PBMC).
Image Unavailable-75842-866

Anti-CD41 Rat Monoclonal Antibody (FITC (Fluorescein Isothiocyanate)) [clone: MWReg30]

Catalog Number: (75842-866)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The MWReg30 monoclonal antibody specifically reacts with mouse CD41, a transmembrane glycoprotein also known as integrin alpha 2b GPIIb. It is expressed on hematopoietic progenitors, megakaryocytes, and platelets. It forms a receptor with CD61 (integrin beta 3) that binds adhesion molecules such as fibrinogen, fibronectin, von Willebrand factor, and thrombin. Defects or absence of CD41 has been found to lead to coagulation disorders. The expression profile of CD150+,CD48-, and CD41- can be used to identify hematopoietic stem cells.
Image Unavailable-75843-860

Anti-CD3 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: UCHT1]

Catalog Number: (75843-860)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The UCHT1 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3ε. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
Image Unavailable-75843-846

Anti-CD3 Mouse Monoclonal Antibody (Biotin) [clone: UCHT1]

Catalog Number: (75843-846)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The UCHT1 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction. Unlike HIT3a, another specific antibody of CD3, the UCHT1 antibody can stain both the surface and intracellular CD3ε. The immobilized UCHT1 can cross-link with the TCR complex, enhancing cellular activation and proliferation.
Image Unavailable-75844-432

Anti-CD117 (c-Kit) (ACK2) Rat Monoclonal Antibody [clone: ACK2]

Catalog Number: (75844-432)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The ACK2 monoclonal antibody specifically reacts with mouse CD117 (c-Kit receptor), a 145 kDa transmembrane tyrosine-kinase receptor encoded by the Kit gene. The c-Kit receptor, also known as stem cell factor receptor, is expressed on hematopoietic progenitor cells in adult bone marrow, in progenitors of erythroid and myeloid lineages, and precursors of B and T cells. CD117 enhances the proliferation and the differentiation of the hematopoietic progenitor cells and seems to enhance the development of T cells, as the c-Kit receptor and its ligand are expressed by the thymus.
Image Unavailable-75844-478

Anti-IL-7RA Rat Monoclonal Antibody (PerCP (Peridinin-Chlorophyll Protein Complex)-Cy5.5®) [clone: A7R34]

Catalog Number: (75844-478)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the α subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127.
Image Unavailable-75841-678

Anti-CD3 Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: 17A2]

Catalog Number: (75841-678)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 17A2 monoclonal antibody specifically reacts with the MouseT lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains γ, δ, and ε subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the 145-2C11 anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 ε chain.
Image Unavailable-75842-930

Anti-CD4 Mouse Monoclonal Antibody (PE (Phycoerythrin)) [clone: OKT4]

Catalog Number: (75842-930)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
Image Unavailable-75842-968

Anti-CD16 /CD32 Rat Monoclonal Antibody [clone: 2.4G2]

Catalog Number: (75842-968)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 2.4G2 monoclonal antibody specifically reacts with an epitope on the extracellular domain of the mouse CD16 (Fc γ III) and CD 32 (Fc γ II). CD16 and CD32 are low affinity receptors for the IgG Fc domain and are expressed by B lymphocytes, NK cells, kupffer cells, mast cells, monocytes, macrophages, granulocytes, immature thymocytes, neutrophils, and some activated mature T cells.The 2.4G2 antibody blocks the binding of immunoglobulins to CD16 and CD32, and possibly to Fc γ I receptor.
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Anti-F4/80 Rat Monoclonal Antibody (Biotin) [clone: BM8.1]

Catalog Number: (75843-740)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The BM8.1 monoclonal antibody specifically binds to the Mouse125 kDa F4/80 antigen, expressed by most mature macrophages. F4/80 is a transmembrane protein used as a marker of macrophages, although it is also expressed on Kupffer and Langerhans cells. The expression of F4/80 antigen is upregulated on bone marrow cells stimulated in vitro with the macrophage colony stimulating factor. The F4/80 antigen is a requirement for the induction of CD8 T cells-mediated peripheral tolerance.
Image Unavailable-75843-696

Anti-CD70 Rat Monoclonal Antibody [clone: FR70]

Catalog Number: (75843-696)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.
Image Unavailable-75843-754

Anti-F4/80 Rat Monoclonal Antibody (PE (Phycoerythrin)) [clone: BM8.1]

Catalog Number: (75843-754)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The BM8.1 monoclonal antibody specifically binds to the Mouse125 kDa F4/80 antigen, expressed by most mature macrophages. F4/80 is a transmembrane protein used as a marker of macrophages, although it is also expressed on Kupffer and Langerhans cells. The expression of F4/80 antigen is upregulated on bone marrow cells stimulated in vitro with the macrophage colony stimulating factor. The F4/80 antigen is a requirement for the induction of CD8 T cells-mediated peripheral tolerance.
Image Unavailable-75842-114

Anti-CD19 Mouse Monoclonal Antibody (PE (Phycoerythrin)-Cy7®) [clone: HIB19]

Catalog Number: (75842-114)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The HIB19 monoclonal antibody reacts with a human 95 kDa transmembrane glycoprotein known as CD19, which is expressed by B lymphocytes during all the developmental stages, except for the terminally differentiated plasma cells. CD19 is also expressed on follicular dendritic cells, and seems to ensure the regulation of B lymphocytes proliferation. CD19, CD21, CD81, MHC class II, and Leu13 can bind together and form a complex which associates with the B cell receptor (BCR) on the surface of B lymphocytes and facilitates the signal transduction.
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