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Catalog Number: (75841-614)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The RPA-2.10 monoclonal antibody specifically binds to human CD2, a 50 kDA type I transmembrane glycoprotein. CD2 is expressed on NK cells, thymocytes, T lymphocytes, and B cell subsets. CD2 is involved in cell-cell adhesion, T cell activation, and T cell signaling. Its ligand is CD58 and it is reported to bind to CD48, CD59, and CD15. The RPA-2.10 antibody is reported to be cross-reactive with pigs and non-human primates..


Catalog Number: (75842-214)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The APA5 monoclonal antibody specifically binds to the mouse CD140a molecule, otherwise known as the Platelet-Derived Growth Factor (PDGF) Receptor alpha chain. CD140a is a receptor tyrosine kinase expressed on embryonic tissues and adult mesenchymal-derived cells. It binds to PDGF A and B chains and is reported to be involved with wound healing and exhibits chemo-attractant properties. The APA5 antibody blocks the binding of PDGF-AA to the PDGF receptor.


Catalog Number: (75844-084)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The HI30 monoclonal antibody specifically reacts with the 180 kDa, 190 kDa, 205 kDa, and 220 kDa isoforms of the human leukocyte common antigen (LCA) CD45. It is expressed on lymphocytes, granulocytes, monocytes, thymocytes, and eosinophils, but not on mature erythrocytes, platelets, mature erythroid cells of bone marrow, and non-hematopoietic tissues. CD45 is essential for T cell activation and the tyrosine phosphatase activity of its intracellular region is integral for signal transduction.


Catalog Number: (75842-168)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The HMb1-1 monoclonal antibody specifically reacts with mouse/rat CD29, a 130 kDA molecule also known as integrin beta 1, GPIIa, and the VLA-beta chain. It is expressed broadly on endothelial cells, epithelial, leukocytes, and smooth muscle. CD29 forms the VLA 1-6 complexes through the non-covalent interaction with the alpha integrins of CD49 a-f. The HMb1-1 antibody is capable of inhibiting T cell proliferation and blocking cell adhesion.


Catalog Number: (75844-466)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The A7R34 monoclonal antibody specifically reacts with the mouse CD127, the α subunit of the IL-7 receptor, expressed by immature B lymphocytes in the bone marrow, CD4-/CD8-, CD4+, and CD8+ thymocytes, and by mature T lymphocytes at low levels. Mature T cells express CD117 at low levels in the periphery.The A7R34 antibody prevents the interaction between IL-7 and its receptor and the binding of mAb SB/199, which also recognizes mouse CD127.


Catalog Number: (75842-912)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.


Catalog Number: (75842-154)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The HIB19 monoclonal antibody specifically reacts with human CD19, a 95kDA type 1 transmembrane glycoprotein also known as B4. It is expressed on all stages of B cell development except for final plasma cells and on follicular dendritic cells. CD19 plays a role in B cell proliferation, activation, and differentiation. It functions as a BCR co-receptor with CD21 and CD81.


Catalog Number: (75842-318)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 2B11 monoclonal antibody specifically reacts with mouse CD184 (CXCR4or Fusin), a seven-transmembrane G-protein-coupled receptor. It is expressed by astrocytes, B cells, T cells, monocytes, neutrophils, neurons, and hematopoietic cell types. CD184 is a coreceptor for X4 HIV-1.The monoclonal 2B11 antibody recognizes the amino terminus of CD184 and has functional activity.


Catalog Number: (75842-842)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The HB5 monoclonal antibody specifically reacts with human CD21, a 145 kDA glycosylated type I integral membrane protein. CD21 is reported to be involved in B cell activation and proliferation. It is expressed on follicular dendritic cells, mature B cells, a subset of T cells, and a subset of epithelial cells. It is the receptor utilized by the Epstein-Barr virus to infect B cells.


Catalog Number: (75843-532)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The MP4-25D2 monoclonal antibody specifically reacts with human Interleukin-4 (IL-4), expressed by the activated T cells and mast cells. IL-4 is species-specific and stimulates the proliferation and differentiation of B lymphocytes. It upregulates the expression of IgE receptors and class II MHC antigen. The MP4-25D2 is a neutralizing antibody and is reported to be cross-reactive with rhesus monkeys.


Catalog Number: (75844-328)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 90 monoclonal antibody specifically bind to mouse CD38, a type II transmembrane glycoprotein. CD38 is expressed on activated T cells, plasma cells, monocytes, and macrophages. In the mouse as opposed to the human, CD38 expression is downregulated on mouse germinal center B cells and plasma cells. CD38 displays cyclase and hydrolase enzymatic activity and is involved in lymphocyte adhesion, activation, and cell signaling. Its ligand is CD31.


Catalog Number: (75841-894)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The UCHL1 monoclonal antibody specifically reacts with human CD45RO, a 180 kDa isoform of the leukocyte common antigen CD45. CD45RO is a transmembrane glycoprotein with tyrosine phosphatase activity and is expressed by majority of thymocytes, monocytes, granulocytes, and activated memory T lymphocytes. The subsets of peripheral T lymphocytes can be discriminated by using the CD45RO and CD45RA expressing cells.


Catalog Number: (75842-162)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The TS2/16 moncolonal antibody specifically reacts with human CD29 (Integrin beta1), a 130 kDA type I glycoprotein expressed on hematopoietic and non-hematopoietic cells. It forms the VLA-(1-6) molecules with integrin alpha-(1-6) and is involved in the adhesion between cell-cell and cell-matrix. The TS2/16 antibody has been found to activate beta 1 integrins.


Catalog Number: (75842-298)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The MR1 monoclonal antibody specifically reacts with mouse CD154, a 39kDA transmembrane glycoprotein also known as CD40 ligand and gp39. CD154 is expressed on activated T cells and plays a role in B-T cell costimulation. The interaction of CD154 with CD40 induces B cell cycle entry and the signaling for T-dependent B cell activation. By interfering with this interaction, the MR1 antibody is reported to inhibit T and B lymphocyte activation.


Catalog Number: (75842-598)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 3G3 monoclonal antibody specifically reacts with the mouse 50-55 kDa Foxp3 protein (JM2, IPEX), a member of the forkhead family of transcription factors. Foxp3 is expressed by the Treg lymphocytes, whose development and function are influenced by the forkhead protein. Ectopic expression of Foxp3 in T lymphocytes inhibits their activity and cytokine expression.Mutations of Foxp3 result in the “scurfy” mice phenotype.


Catalog Number: (75842-600)
Supplier: BIOGEMS INTERNATIONAL INC.
Description: The 3G3 monoclonal antibody specifically reacts with the mouse 50-55 kDa Foxp3 protein (JM2, IPEX), a member of the forkhead family of transcription factors. Foxp3 is expressed by the Treg lymphocytes, whose development and function are influenced by the forkhead protein. Ectopic expression of Foxp3 in T lymphocytes inhibits their activity and cytokine expression.Mutations of Foxp3 result in the “scurfy” mice phenotype.


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