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Fmoc-Tyr(So2(Oneopentyl))-Oh

Supplier: Bachem Americas
Description: Fmoc-Tyr(SO₃nP), a protected derivative of sulfotyrosine. The neopentyl ester is stable under the conditions of Fmoc-SPPS including the TFA-cleavage, but can be removed by treatment with aqueous ammonium acetate or sodium acetate. Thus, premature loss of sulfate groups during the final deprotection is prevented.

Image Unavailable-75912-080

Anti-ICAM3 Mouse Monoclonal Antibody [clone: ICAM3/1019]

Catalog Number: (75912-080)
Supplier: Biotium
Description: This antibody recognizes an N-glycosylated glycoprotein of 120 kDa with intra-chain disulfide bonds, identified as CD50 or ICAM-3. CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signaling role to increase adhesion. It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C. This MAb is excellent for staining of formalin/paraffin tissues.
Product Image-89417-554

Anti-ALKBH2 Rabbit Polyclonal Antibody

Catalog Number: (89417-554)
Supplier: Prosci
Description: ALKBH2 Antibody: The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA; ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.
Product Image-76516-452

PURELAB® Chorus 2+ Water Purification System, ELGA LabWater

Catalog Number: (76516-452)
Supplier: ELGA LabWater
Description: The PURELAB Chorus 2+ range provide >15 MΩ.cm pure water. The systems provide additional bacteria and inorganic quality for sensitive analytical and life science applications above that of basic laboratory work. With its simple design and ease of use, water can be dispensed from the system or from a choice of additional Halo Dispensers.
Image Unavailable-10481-176

Anti-DPYD Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10481-176)
Supplier: Bioss
Description: Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
Image Unavailable-10481-180

Anti-DPYD Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10481-180)
Supplier: Bioss
Description: Dihydropyrimidine dehydrogenase (DPYD) catalyzes the first rate-limiting step of the NADPH-dependent catabolism of uracil and thymine to dihydrouracil and dihydrothymine; thus, a deficiency of DPYD leads to an accumulation of uracil and thymine. Abnormal concentrations of these metabolites in bodily fluids may be the cause of neurological disease and a contraindication for treatment of cancer patients with certain pyrimidine analogs. DPYD also catalyzes the anticancer agent 5-fluorouracil (5-FU) pathway and is involved in the efficacy and toxicity of 5-FU. Variations in DPYD concentration may arise from alterations at the transcriptional level of the dihydropyrimidine dehydrogenase gene. Specifically, hypermethylation of the DPYD promoter downregulates dihydropyrimidine dehydrogenase expression. Deficient DPYD alleles may constitute a risk factor for severe toxicity following treatment with 5-FU.Involvement in disease:Defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) ; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
Product Image-10822-048

Human Recombinant IFNalpha 2b (from E. coli)

Supplier: FUJIFILM IRVINE SCIENTIFIC, INC
Description: Interferon-alpha 2b (IFN-α2b) is a type I interferon made by leukocytes during viral infection. The JAK-STAT pathway mediates the antiviral and anti-cell proliferation activities of IFN-α2b. IFN-α proteins are widely used as standard treatments during antiviral and antineoplastic therapies. The IFN-α2b variant differs from IFN-α2a by one amino acid.

Image Unavailable-H-7415.0001BA

Acetyl-Hirudin (54-65) (Sulfated)

Catalog Number: (H-7415.0001BA)
Supplier: Bachem Americas
Description: These peptides correspond to the C-terminus of the 65-residue polypeptide hirudin, a potent thrombin inhibitor found in the saliva of the leech Hirudo medicinalis. Treatment of hirudin with carboxypeptidase Y has shown that the last 5 amino acids are essential for its inhibitory activity.
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arium® comfort Pre-treatment Cartridge, Sartorius

Catalog Number: (CA76533-172)
Supplier: Sartorius
Description: Pre-filter consisting of high efficient activated carbon combined with a process optimizing catalyst. Removes reliable oxidizing agents, heavy metals, and particular impurities.
Image Unavailable-H-8190.0001BA

Hirugen

Catalog Number: (H-8190.0001BA)
Supplier: Bachem Americas
Description: These peptides correspond to the C-terminus of the 65-residue polypeptide hirudin, a potent thrombin inhibitor found in the saliva of the leech Hirudo medicinalis. Treatment of hirudin with carboxypeptidase Y has shown that the last 5 amino acids are essential for its inhibitory activity.
Product Image-10110-140

Anti-STK3 Rabbit Polyclonal Antibody

Catalog Number: (10110-140)
Supplier: Prosci
Description: Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand.Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was identified as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996 [PubMed 8816758]; Lee et al., 2001 [PubMed 11278283]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-11 U26424.1 1-11 12-2826 BC010640.2 1-2815
Product Image-10194-524

Sklarlite XD™ Strabismus Scissors, OR Grade, Sklar®

Supplier: Sklar
Description: Sklarlite XD™ Strabismus Scissors are an ophthalmic dissecting instrument primarily used during procedures for the treatment of Strabismus, otherwise known as "cross-eyes." Sklarlite XD™ instruments are noticeably lighter and delicate than standard instruments which allow the surgeon the highest degree of precision with the least amount of fatigue

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arium® RO Pre-treatment Cartridge, Sartorius

Catalog Number: (CA76533-170)
Supplier: Sartorius
Description: Reliably removes oxidizing agents, heavy metals, and particular impurities.
Product Image-23050-344

Pre-Cleaned Bottles, HDPE, Wide Mouth, Environmental Express

Supplier: Environmental Express
Description: All containers meet one of two levels of pre-cleaning. Level III indicates that containers have not received an EPA washing treatment. Level I indicates each case of containers have been custody-sealed and lot number-labeled for traceability.

Small Business Enterprise

Product Image-CA89020-078

A800 Series Protective Eyewear, Honeywell Safety

Supplier: Honeywell Safety Products
Description: Stylish, sporty, and economic A800 series eyewear provides fashionable protection for the everyday wearer.

Image Unavailable-76121-230

Anti-HBeAg Mouse Monoclonal Antibody [clone: 2E9] (ALEXA FLUOR® 680)

Catalog Number: (76121-230)
Supplier: Bioss
Description: Hepatitis B e-antigen (HBeAg) is a viral protein associated with HBV infections. Unlike the surface antigen, the e-antigen is found in the blood only when there are viruses also present. When the virus goes into hiding,? the e-antigen will no longer be present in the blood. HBeAg is often used as a marker of ability to spread the virus to other people (infectivity). Measurement of e-antigen may also be used to monitor the effectiveness of HBV treatment; successful treatment will usually eliminate HBeAg from the blood and lead to development of against e-antigen (anti-HBe). There are some types (strains) of HBV that do not make e-antigen; these are especially common in the Middle East and Asia. In areas where these strains of HBV are common, testing for HBeAg is not very useful.

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