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Product Image-CA200061-476

Anti-OPN Mouse Monoclonal Antibody [clone: 87-B]

Catalog Number: (CA200061-476)
Supplier: Enzo Life Sciences
Description: Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to provide prognostic information in breast, prostate, colon, and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.
Product Image-MFLX40615-55

Masterflex® Adapter Fittings, Hose Barb Tees, PVDF, Avantor®

Catalog Number: (MFLX40615-55)
Supplier: VWR International
Description: Quick and easy assembly.

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Product Image-89026-268

VWR® Stirrer Blades with Plain Ends

Supplier: VWR International
Description: Blades fit PTFE stirring shaft; hole diameter 6.5 mm, 3.2 mm thick.

Product Image-MFLX40623-16

Masterflex® Union Fittings, Hose Barb, Elbow, Nylon, Avantor®

Supplier: VWR International
Description: Quick and easy assembly without tools.

Image Unavailable-10496-212

Anti-CHPT1 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10496-212)
Supplier: Bioss
Description: CHPT1, also known as AAPT1-like protein and Diacylglycerol cholinephosphotransferase 1, is a 406 amino acid multi-pass membrane protein that is localized to the golgi apparatus. By catalyzing the phosphatidylcholine biosynthesis from CDP-choline, it plays an essential role in the formation and maintenance of vesicular membranes. CHPT1 is most abundant in testis, as well as small intestine, heart, colon, spleen and prostate. Expression of CHPT1 is increased in cancerous breast cells as compared to normal breast cell lines and it has been determined that the CHPT1 gene exhibits mutations within the cancerous cells. Interestingly, exposure to mustard gas significantly decreases CHPT1 gene expression and activity, an event that may play an important role in the development of acute respiratory distress syndrome (ARDS). There are two isoforms of CHPT1 that are produced as a result of alternative splicing events.
Image Unavailable-89126-634

VWR® TraceClean® LDPE Cubitainers (Collapsible Containers), Natural

Catalog Number: (89126-634)
Supplier: VWR International
Description: These TraceClean® containers are cleaned by Protocol “A”, and are used primarily for grab and compositing of aqueous samples for testing metals and inorganic analytes.

Certificates Small Business Enterprise


Product Image-MFLX98906-12

Masterflex® Transfer Tubing Spool, Platinum-Cured Silicone, Avantor®

Supplier: VWR International
Description: Low compression formulation keeps its shape and cleanliness.

Certificates CE certificate

Product Image-MFLX06602-20

Masterflex® Transfer Tubing, PVC Reinforced, Avantor®

Supplier: VWR International
Description: More durable than standard PVC.

Certificates CE certificate

Product Image-MFLX30620-21

Masterflex® Union Fittings, Hose Barb, Y-Connector, Stainless Steel, Avantor®

Catalog Number: (MFLX30620-21)
Supplier: VWR International
Description: Ensure a tight seal every time.

Certificates


Product Image-MFLX50623-57

Masterflex® Union Fittings, Hose Barb, Tee, Polypropylene, Avantor®

Supplier: VWR International
Description: No tools needed for assembly.

CE certificate

Product Image-10493-700

Anti-SLC39A11 Rabbit Polyclonal Antibody

Catalog Number: (10493-700)
Supplier: Bioss
Description: Zinc is an essential cofactor that is involved in cell growth and development, as well as in protein, nucleic acid and lipid metabolism. The transport of zinc across the cell membrane is crucial for correct enzyme and overall cell function. SLC39A11 (solute carrier family 39 (metal ion transporter), member 11), also known as ZIP11 (Zrt- and Irt-like protein 11), is a 342 amino acid multi-pass membrane protein belonging to the ZIP transporter family. Expressed as multiple alternatively spliced isoforms, SLC39A11 acts as a zinc-influx transporter and is encoded by a gene located on human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes, some of which are involved in tumor suppression and in the pathogenesis of Li-Fraumeni syndrome, early onset breast cancer and a predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Image Unavailable-10083-298

Anti-BMP7 Rabbit Polyclonal Antibody

Catalog Number: (10083-298)
Supplier: Proteintech
Description: The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.
BMP7, also known as osteogenic protein-1 or OP-1, plays a key role in the transformation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis . It is expressed in the brain, kidneys and bladder. BMP7 is also present in cancers, including breast, prostate, and colon cancers, in which it is implicated in regulating cancer cell proliferation . Overexpression of BMP7 mRNA in colorectal cancer patients was significantly associated with poor prognosis and low overall survival . Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC .
Image Unavailable-10489-716

Anti-TSPAN10 Rabbit Polyclonal Antibody

Catalog Number: (10489-716)
Supplier: Bioss
Description: The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. Oculospanin, also known as tetraspanin 10 (TSPAN10) or OCSP, is a 355 amino acid multi-pass membrane protein belonging to the tetraspanin (TM4SF) family. Oculospanin is expressed in certain regions of the eye such as retinal pigment epithelium, ciliary body and iris, but is not found in the lens. The gene encoding Oculospanin maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is liked to predisposition of cancers of the ovary, colon, prostate gland and fallopian tubes.
Image Unavailable-10493-770

Anti-DERP6 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10493-770)
Supplier: Bioss
Description: DERP6, is a 316 amino acid protein that localizes to the cytoplasm and exists as multiple alternatively spliced isoforms. Expressed ubiquitously with highest expression in liver, heart, testis, brain and skeletal muscle, DERP6 is thought to be involved in p53-mediated transcriptional regulation. The gene encoding DERP6 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Image Unavailable-10496-322

Anti-TSSK6 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10496-322)
Supplier: Bioss
Description: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility.
Image Unavailable-10496-324

Anti-TSSK6 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10496-324)
Supplier: Bioss
Description: The phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions in eukaryotes, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the serine/threonine (Ser/Thr) protein kinases. TSSK 6 (testis-specific serine kinase 6), also known as SSTK, TSSK4, FKSG82 or CT72, is a 273 amino acid protein that contains one protein kinase domain and belongs to the Ser/Thr protein kinase family. Highly expressed in testis with lower expression in ovary, colon, thymus, small intestine and spleen, TSSK 6 catalyzes the ATP-dependent phosphorylation of proteins involved in sperm production and chromatin remodeling. TSSK 6 uses magnesium as a cofactor and is thought to be required for proper sperm development and function, as well as DNA condensation events. Defects in the gene encoding TSSK 6 are associated with male infertility characterized by low sperm count and decreased sperm motility.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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