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Product Image-10068-714

Anti-JAK2 Rabbit Polyclonal Antibody

Catalog Number: (10068-714)
Supplier: Prosci
Description: Plays a role in leptin signaling and control of body weight
Product Image-10070-594

Anti-IGF1R Mouse Monoclonal Antibody [clone: 3G5C1]

Catalog Number: (10070-594)
Supplier: Prosci
Description: IGF1R(insulin-like growth factor 1 receptor), a transmembrane receptor tyrosine kinase, is widely expressed in many cell types within fetal and postnatal tissues, and in many cell lines. Upon binding to its ligands, IGF-I and IGF-II, receptor autophosphorylation occurs. The triple tyrosine cluster within the kinase domain (Tyr1131, Tyr1135 and Tyr1136) is the earliest major site of autophosphorylation. Phosphorylation of these three tyrosine residues is necessary for kinase activation.Insulin receptors (IRs) share significant similarity with IGF1 receptors in both structure and function,including an equivalent triple tyrosine cluster within the activation loop of the kinase domain (Tyr1146, Tyr1150 and Tyr1151).Tyrosine autophosphorylation of insulin receptor is one of the earliest cellular responses to insulin stimulation. Autophosphorylation begins with phosphorylation of Tyr1146 and either Tyr1150 or Tyr1151. Full kinase activation requires the triple tyrosine phosphorylation.
Image Unavailable-89290-388

Anti-MYT1 Rabbit Polyclonal Antibody

Catalog Number: (89290-388)
Supplier: Genetex
Description: Rabbit polyclonal antibody to MYT1
Image Unavailable-89269-276

Anti-DYRK1A Rabbit Polyclonal Antibody

Catalog Number: (89269-276)
Supplier: Genetex
Description: Rabbit polyclonal antibody to DYRK1A (N-terminal)
Product Image-10068-910

Anti-JUN Rabbit Polyclonal Antibody

Catalog Number: (10068-910)
Supplier: Prosci
Description: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.
Image Unavailable-89272-754

Anti-NTRK3 Mouse Monoclonal Antibody [clone: 2B8]

Catalog Number: (89272-754)
Supplier: Genetex
Description: Mouse monoclonal antibody [2B8] to NTRK3
Product Image-89276-742

Anti-FLT3 Rabbit Polyclonal Antibody

Catalog Number: (89276-742)
Supplier: Genetex
Description: Rabbit polyclonal antibody to FLT3 (phospho Y591)
Image Unavailable-102978-608

Anti-VEGFR-1 Monoclonal Antibody [clone: EWC]

Catalog Number: (102978-608)
Supplier: Adipogen
Description: Recombinant human soluble vascular endothelial growth factor receptor-1 (sVEGFR-1) is the naturally occurring form and is a glycosylated monomeric protein. The biological function of sVEGFR-1 seems to be an endogenous regulator of angiogenesis, binding VEGF with the same affinity as the full-length receptor. VEGFR-1 is a tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis and cancer cell invasion. It may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. It can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts (in vitro). It has a very high affinity for VEGFA and relatively low protein kinase activity. It may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of phospholipase C-gamma (PLCG) leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1 and may also phosphorylate CBL.
Product Image-10070-056

Anti-CTNNB1 Rabbit Polyclonal Antibody

Catalog Number: (10070-056)
Supplier: Prosci
Description: Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.
Image Unavailable-76100-094

Anti-LTK Rabbit Polyclonal Antibody (ALEXA FLUOR® 680)

Catalog Number: (76100-094)
Supplier: Bioss
Description: LTK is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
Image Unavailable-89301-748

Anti-TRKA Rabbit Polyclonal Antibody

Catalog Number: (89301-748)
Supplier: Genetex
Description: Rabbit polyclonal to TrkA
Product Image-89147-626

Compound 56 ≥97% (by HPLC)

Catalog Number: (89147-626)
Supplier: Enzo Life Sciences
Description: Potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC50=6pM).
Product Image-10068-938

Anti-CDK1 Rabbit Polyclonal Antibody

Catalog Number: (10068-938)
Supplier: Prosci
Description: Plays a key role in the control of the eukaryotic cell cycle. It is required in higher cells for entry into S-phase and mitosis. p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II.
Image Unavailable-89272-336

Anti-PTPRE Mouse Monoclonal Antibody [clone: 3D4]

Catalog Number: (89272-336)
Supplier: Genetex
Description: Mouse monoclonal antibody [3D4] to PTPRE
Image Unavailable-89293-314

Anti-TTLL4 Goat Polyclonal Antibody

Catalog Number: (89293-314)
Supplier: Genetex
Description: Goat polyclonal antibody to TTLL4
Image Unavailable-89359-942

Anti-14-3-3 Mouse Monoclonal Antibody [clone: 3F7]

Catalog Number: (89359-942)
Supplier: Genetex
Description: Members of the 14-3-3 family of proteins are highly conserved proteins, localized in neurons, and are axonally transported to the nerve terminals. They are also present, at lower levels, in various other eukaryotic tissues. 14-3-3 proteins appear to play important roles in a variety of signal transduction pathways, including those involved in cell cycle regulation and cell survival. Because 14-3-3 proteins bind to specific phosphoserine-containing sequences they are likely to have an important role in signaling pathways mediated by serine/threonine protein kinases. Evidence indicates 14-3-3 is required for Raf-1 kinase activity and phosphorylation amoung many other functions.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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