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Image Unavailable-10081-910

Anti-AGT Rabbit Polyclonal Antibody

Catalog Number: (10081-910)
Supplier: Proteintech
Description: Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Image Unavailable-10081-912

Anti-AGT Rabbit Polyclonal Antibody

Catalog Number: (10081-912)
Supplier: Proteintech
Description: Angiotensinogen is a precursor of angiotensin II (Ang II), is expressed and synthesized largely in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. It has a key role in mediating vascular constriction and regulating salt and fluid homeostasis. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Product Image-CA16007-000

Technovit® 7100 and 8100 Embedding Kits, Electron Microscopy Sciences

Supplier: VWR International
Description: Technovit® Glycol Methacrylate embedding kits developed by Kulzer in Germany are the most convenient to use and offer the best embedding results with improved morphology and 1 micron serial sectioning.

Product Image-89160-350

FLUOR DE LYS®-Sirt2 Deacetylase Substrate

Catalog Number: (89160-350)
Supplier: Enzo Life Sciences
Description: Fluor de Lys®-SIRT2 is a fluorogenic peptide substrate for SIRT2 (human Sirtuin 2). Based on residues 317-320 of p53 (Gln-Pro-Lys-Lys(Ac)), a site of regulatory acetylation by the PCAF acetyltransferase (lysine 320), it was the best for SIRT2 from among a panel of substrates patterned on p53, Histone H3, and Histone H4 acetylation sites. Fluor de Lys®-SIRT2 is deacetylated by SIRT2 at a rate of more than 50-fold that of the acetylated lysine substrate, Fluor de Lys® (BML-KI104; acetylated substrates both at 25 µM, 500 µM NAD+). Must be used in conjunction with Fluor de Lys® Developer II (BML-KI176). Sufficient for 100 assays of human recombinant SIRT2 (BML-SE251; 2U/well, 100 µM substrate).
Image Unavailable-10664-178

Anti-FOXA1 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10664-178)
Supplier: Bioss
Description: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
Product Image-CA14577-99

Ascorbic Acid Powder Pillows, Hach

Catalog Number: (CA14577-99)
Supplier: Hach
Description: Reagent for aluminum determination by the aluminon method (Method 8012), manganese determination by the PAN method (Method 8149) and total chelant determination by titration (Method 8350).
Product Image-470203-126

LaMotte® Salinity Test Kit

Supplier: LaMotte
Description: This kit test for salinity using the Direct Reading Titrator method.

Image Unavailable-66170-492

QAC Test Kit, La Motte

Catalog Number: (66170-492)
Supplier: LaMotte
Description: This kit tests for QAC using the direct reading titrator method and is best suited to higher QAC concentrations.

Small Business Enterprise


Product Image-76262-738

Anti-TP53 Rabbit Polyclonal Antibody

Catalog Number: (76262-738)
Supplier: Rockland Immunochemical
Description: TP53 (tumor suppressor gene p53) is one of the most well-studied genes that suppresses tumor formation and renders protection against DNA damage by inducing cell cycle arrest, DNA repair, or apoptosis. TP53 signaling is triggered through numerous cellular events ranging from DNA damage to hypoxia, stress and a plethora of other causes. Upon activation, p53 acts as zinc-containing transcriptional regulator and initiates a cascade of events that determines the cellular outcome including cell cycle arrest, apoptosis, senescence, DNA repair, development, differentiation and tissue homeostasis. Cell cycle arrest is induced by p53 via trans-activating genes such as p21 (CDK-inhibitor 1, cyclin dependent kinase) and others. Interestingly, p53 itself is capable of triggering cellular responses (survival or induced cell death) as well. Mutations or deletions in the TP53 gene are present in nearly 50% of human cancers, and primarily results in impaired tumor suppressor function. Anti-p53 (ac Lys305) antibody is ideal for researchers interested in developmental biology, cell growth and cancer research.
Product Image-89160-346

FLUOR DE LYS®-Sirt1 Deacetylase Substrate

Catalog Number: (89160-346)
Supplier: Enzo Life Sciences
Description: Fluor de Lys®-SIRT1 is a fluorogenic, acetylated peptide substrate for SIRT1 (human Sirtuin 1). Based on residues 379-382 of p53 (Arg-His-Lys-Lys(Ac)), a site of regulatory acetylation by the p300 and CBP acetyltransferases (lysines 381, 382), it was the best substrate for SIRT1 from among a panel of substrates patterned on p53, histone H3, and histone H4 acetylation sites. Fluor de Lys®-SIRT1 is deacetylated by SIRT1 (BML-SE239) at a rate of more then 8-fold that of the acetylated lysine substrate, Fluor de Lys® (Prod. No. BML-KI104; acetylated substrates both at 25 µM, 500 µM NAD+). The Km of Fluor de Lys®-SIRT1 for human recombinant Sirtuin 1 is 108 µM (determined at 37°C, 500 µM NAD+). Must be used in conjunction with Fluor de Lys® Developer II (Prod. No. BML-KI176). Fluorescent signal indicates deacetylation of Lys382. Sufficient for 100-200 assays of human recombinant SIRT1 (1U/well, 50-100 µM substrate).
Product Image-89056-108

Extraction Apparatus, Priority Pollutant Analysis, Ace Glass

Supplier: Ace Glass
Description: This apparatus is designed for the U.S.E.P.A

Small Business Enterprise Product available on GSA Advantage®

Product Image-76262-740

Anti-TP53 Rabbit Polyclonal Antibody

Catalog Number: (76262-740)
Supplier: Rockland Immunochemical
Description: TP53 (tumor suppressor gene p53) is one of the most well-studied genes that suppresses tumor formation and renders protection against DNA damage by inducing cell cycle arrest, DNA repair, or apoptosis. TP53 signaling is triggered through numerous cellular events ranging from DNA damage to hypoxia, stress and a plethora of other causes. Upon activation, p53 acts as zinc-containing transcriptional regulator and initiates a cascade of events that determines the cellular outcome including cell cycle arrest, apoptosis, senescence, DNA repair, development, differentiation and tissue homeostasis. Cell cycle arrest is induced by p53 via trans-activating genes such as p21 (CDK-inhibitor 1, cyclin dependent kinase) and others. Interestingly, p53 itself is capable of triggering cellular responses (survival or induced cell death) as well. Mutations or deletions in the TP53 gene are present in nearly 50% of human cancers, and primarily results in impaired tumor suppressor function. Anti-p53 (ac Lys305) antibody is ideal for researchers interested in developmental biology, cell growth and cancer research.
Product Image-95026-866

Nitrate, CHEMets Visual Kit, CHEMetrics

Supplier: CHEMetrics
Description: Nitrate is reduced to nitrite using cadmium as the reducing agent. The resulting nitrite concentration is then determined colorimetrically. This method is applicable to drinking and surface waters, as well as domestic and industrial wastes.

Small Business Enterprise

Product Image-CXR-9400

CHEMets® Visual Kit, Detergents (anionic surfactants, MBAS method), Chemetrics

Supplier: CHEMetrics
Description: Ideal for testing detergents (anionic surfactants, MBAS method) in water.

SDS Small Business Enterprise

Product Image-CA21074-69

Acid Reagent Powder Pillows for HR Silica, Hach

Catalog Number: (CA21074-69)
Supplier: Hach
Description: For determination of high range silica by the silicomolybdate method (Hach method 8185) Range: 1-100.0 mg/L SiO2

SDS


Image Unavailable-10664-180

Anti-FOXA1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10664-180)
Supplier: Bioss
Description: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
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