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Catalog Number: (10452-886)
Supplier: Bioss
Description: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.


Catalog Number: (10452-832)
Supplier: Bioss
Description: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.


Catalog Number: (76118-644)
Supplier: Bioss
Description: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.


Catalog Number: (89424-208)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to CDC42EP1 (CDC42 effector protein (Rho GTPase binding) 1)


Catalog Number: (89359-574)
Supplier: Genetex
Description: GDP - Dissociation inhibitors (GDIs) modulate GTPase activity by binding to small G-proteins and regulating GDP/GTP exchange of inflammatory cell activity, including motility, formation of toxic oxygen metabolites and generation of proinflammatory cytokines. RhoGDI may also be critical for the cellular compartmentalization of GTPases. RhoGDI, which can bind to Rho, Rac, and cdc42, is localized in the cytosol. D4GDI, an abundant hematopoietic cell GDI for the Ras-related Rho family GTPases, is a substrate of the apoptosis protease.


Catalog Number: (10103-982)
Supplier: Prosci
Description: RP13-102H20.1 is the GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.


Catalog Number: (10423-514)
Supplier: Bioss
Description: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.


Catalog Number: (89357-416)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to ROCK1 (Rho-associated, coiled-coil containing protein kinase 1)


Catalog Number: (10814-104)
Supplier: Prosci
Description: CRMP-2 is an enzyme with dihydropyrimidinase activity. Plays a role in RhoA-dependent signaling, through interaction with and regulation of Rho kinase. Plays a role in neurogenesis. Aberrantly expressed in fetal Down syndrome brain.


Catalog Number: (76117-484)
Supplier: Bioss
Description: Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.


Catalog Number: (76101-742)
Supplier: Bioss
Description: GEF-H1 is a Rho guanine nucleotide exchange factor that localizes to microtubules and regulates Rho activity in response to microtubule destabilization (loss of interaction between GEF-H1 and microtubules leads to activation of Rho). This protein has also been shown to localize to tight junctions and modulate polarized cell permeability.


Catalog Number: (10084-606)
Supplier: Proteintech
Description: CIT, also named KIAA0949, STK21 and CRIK, belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. It is required for KIF14 localization to the central spindle and midbody. CIT may play a role in cytokinesis. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. CIT plays an important role in the regulation of cytokinesis and the development of the central nervous system. The antibody recognizes all the isoformes of CIT.


Catalog Number: (89319-632)
Supplier: Genetex
Description: Rabbit polyclonal antibody to GEF5 (Rho guanine nucleotide exchange factor (GEF) 5)


Catalog Number: (10338-528)
Supplier: Bioss
Description: GEF-H1 is a Rho guanine nucleotide exchange factor that localizes to microtubules and regulates Rho activity in response to microtubule destabilization (loss of interaction between GEF-H1 and microtubules leads to activation of Rho). This protein has also been shown to localize to tight junctions and modulate polarized cell permeability.


Catalog Number: (10452-880)
Supplier: Bioss
Description: Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.


Catalog Number: (89348-666)
Supplier: Genetex
Description: Rabbit Polyclonal antibody to RAC1 (ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1))


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