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Catalog Number: (76170-576)
Supplier: Prosci
Description: KIDNEY TISSUE LYSATE TUMOR AGE 54 0.1MG


Catalog Number: (ABCA_AB144444-10MG)
Supplier: Abcam
Description: GW 9508, FFA1 RECEPTOR AG AB144444-10MG

New Product


Catalog Number: (75971-808)
Supplier: Biotium
Description: MAB PROSTATE SPECIFIC AG 1A7 CF647 100UL


Catalog Number: (75972-408)
Supplier: Biotium
Description: MAB PROSTATE SPECIFIC AG 1A7 50 UL F/IF


Catalog Number: (75972-636)
Supplier: Biotium
Description: MAB PROSTATE SPEF AG KLK3 CF488A 100UL


Catalog Number: (75972-666)
Supplier: Biotium
Description: MAB PROSTATE SPEF AG KLK3 CF488A 500UL


Catalog Number: (104014-384)
Supplier: ACRO Biosystems
Description: LYSIS BUFFER FOR SARS-COV2 AG TEST 100ML


Catalog Number: (77870-928)
Supplier: Thermo Fisher Scientific
Description: ELECTRODE PH COMBO AG AGCL ECO SERIES

New Product


Catalog Number: (470043-148)
Supplier: RICKIE CROSSLIN
Description: SOIL ORDOVICIAN AGE FOSSIL 1 KG 67308-29


Catalog Number: (102979-190)
Supplier: Adipogen
Description: Unmethylated CG dinucleotides within particular sequence contexts are responsible for the immunostimulatory activity of bacterial DNA. Synthetic oligonucleotides (ODN) that contain such CpG motifs (CpG ODNs) mimic microbial DNA. The innate immune system of vertebrates has the ability to recognize CpG motifs in microbial DNA via the Toll-like receptor (TLR) 9 if the CpG ODN were free of additional immune stimulatory contaminants often present in synthetic commercial CpG ODN preparations designed for molecular biology applications (i.e. PCR). Given that high quality CpG ODNs were used, a close link has been established between the expression of TLR9 on certain immune cell subsets and the modulation of the immune system by CpG DNA. Different types of CpG ODNs were identified based on their differing biological effects on different cell types: ODN Type A is a potent inducer of IFN-alpha in human PDC, (i.e. ODN 1585 or 2216) leading to antigen presenting cell (APC) maturation, whereas ODN Type B (i.e. ODN 2006 or ODN 1668 / ODN 1826) is a weak inducer of IFN-alpha but rather stimulates IL-8 production and increasing costimulatory and Ag-presenting molecules and triggers proliferation of B-cells and IgM and IL-6 production. A third type of CpG ODN has been identified, termed ODN Type C, with both high induction of INF-alpha in PDC and activation of B-cells. The sequence of CpG Type C (also called K) (i.e. ODN 2395 or M362) combines elements of both Type A and Type B and contains a central palindromic sequence with CG dinucleotides, a characteristic feature of Type A, and a TCGTCG motif at the 5' end, present in Type B CpG ODNs. Although the CpG motifs are thought to differ between mice and humans, in both species the recognition of CpG ODNs is mediated by TLR9. The optimal CpG motif in humans is GTCGTT and GACGTT for the murine sequence. However, recent evidence suggests that this sequence specificity is restricted to phosphorothioate (PS)-modified ODN and is not observed when a natural phosphodiester backbone is used. In recent years sequence requirements, specificity, signalling pathways and kinetics of the TLR9 suppression by inhibitory ODNs (iODNs) have been investigated.


Catalog Number: (ABCA_AB144444-50MG)
Supplier: Abcam
Description: GW 9508, FFA1 RECEPTOR AG AB144444-50MG

New Product


Catalog Number: (89522-346)
Supplier: Optimize
Description: PTFE PLUNGER SEAL GREEN PREMIUM GRADE AG


Catalog Number: (75972-434)
Supplier: Biotium
Description: MAB PRST SPEF AG A67-B CF405S 500UL F/IF


Catalog Number: (75973-190)
Supplier: Biotium
Description: MAB PROSTATE SPEF AG KLK3 CF405S 500UL


Catalog Number: (75973-188)
Supplier: Biotium
Description: MAB PROSTATE SPEF AG KLK3 CF405S 100UL


Catalog Number: (76170-578)
Supplier: Prosci
Description: KIDNEY TISSUE LYSATE TUMOR AGE 66 0.1MG


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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