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You Searched For: 7.2+CPG+[TQ7.2+CPG]


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Image Unavailable-77440-022

Anti-TLR9 Rabbit Polyclonal Antibody

Catalog Number: (77440-022)
Supplier: Bioss
Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Jul 2008]
Product Image-10102-308

Anti-MBD3 Rabbit Polyclonal Antibody

Catalog Number: (10102-308)
Supplier: Prosci
Description: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex.DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). However, unlike the other family members, MBD3 is not capable of binding to methylated DNA. The predicted MBD3 protein shares 71% and 94% identity with MBD2 (isoform 1) and mouse Mbd3. MBD3 is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. MBD3 mediates the association of metastasis-associated protein 2 (MTA2) with the core histone deacetylase complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Product Image-76023-994

ZING Green Safety Eco Traffic Sign Traffic CAUTION Speed Bump

Catalog Number: (76023-994)
Supplier: ZING Enterprises
Description: Alerts drivers to take precautionary measures and ensure public safety.

Environmentally Preferable


Image Unavailable-76108-566

Anti-TMEM173 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76108-566)
Supplier: Bioss
Description: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Image Unavailable-10402-578

Anti-CHFR Rabbit Polyclonal Antibody

Catalog Number: (10402-578)
Supplier: Bioss
Description: A number of human cancers are sensitive to mitotic stress, implying checkpoint defects. Many proteins that contain forkhead-associated (FHA) domains are cell cycle checkpoints and CHFR is one such protein. It has a FHA and ring finger domain within its N terminus. Within its C terminus, CHFR contains a cysteine-rich region that did not display significant similarity to any protein in the GenBank database, but is highly conserved between humans and mice. It has been concluded that CHFR defines a checkpoint that delays entry into metaphase in response to mitotic stress. It has been found CpG methylation-dependent silencing of CHFR expression occurs in 45% of cancer cell lines, 40% of primary colorectal cancers, 53% of colorectal adenomas, and 30% of primary head and neck cancers.
Image Unavailable-103007-656

[Lys(Ac)14]-Histone H3 (9-19)

Catalog Number: (103007-656)
Supplier: Anaspec Inc
Description: This is a H3 peptide acetylated at the lysine residue at the 14th position. This peptide has been shown to act as part of the active promoter state and the extent of its acetylation could be driven by cis regulatory elements such as CpG contents at promoters. It's expression has been shown to be decreased as malignancy of ovarian epithelial tumors increased, suggesting that this peptide could act as a prognostic marker although it does not show significant relation with the occurence or development of ovarian tumors.
Sequence:KSTGG-K(Ac)-APRKQ
MW:1199.4 Da
% peak area by HPLC:95
Storage condition:-20° C
Image Unavailable-89366-736

Anti-MECP2 Rabbit Polyclonal Antibody

Catalog Number: (89366-736)
Supplier: Genetex
Description: Rabbit polyclonal antibody to MeCP2 (phospho Ser80)
Image Unavailable-10482-048

Anti-TMEM173 Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10482-048)
Supplier: Bioss
Description: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Image Unavailable-10482-052

Anti-TMEM173 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10482-052)
Supplier: Bioss
Description: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Image Unavailable-10482-050

Anti-TMEM173 Rabbit Polyclonal Antibody (Cy5.5®)

Catalog Number: (10482-050)
Supplier: Bioss
Description: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Image Unavailable-10482-054

Anti-TMEM173 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Catalog Number: (10482-054)
Supplier: Bioss
Description: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
Product Image-10107-754

Anti-MBD1 Rabbit Polyclonal Antibody

Catalog Number: (10107-754)
Supplier: Prosci
Description: MBD1 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD1 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. Five transcript variants of the MBD1 are generated by alternative splicing resulting in protein isoforms that contain one MBD domain, two to three cysteine-rich (CXXC) domains, and some differences in the COOH terminus. All five transcript variants repress transcription from methylated promoters; in addition, variants with three CXXC domains also repress unmethylated promoter activity. MBD1 and MBD2 map very close to each other on chromosome 18q21.
Image Unavailable-10487-472

Anti-VPRBP Rabbit Polyclonal Antibody (Cy5®)

Catalog Number: (10487-472)
Supplier: Bioss
Description: P55 is an extensively palmitoylated erythrocyte membrane protein, and a member of the MAGUK family. P55 also resists salt extraction, resulting in a high affinity for the plasma membrane. P55 contains a PDZ/DHR domain, a conserved SH-3 domain that appears to suppress tyrosine kinase activity of various oncoproteins, a 39-amino acid motif that binds to cytoskeletal protein 4.1R, and a guanylate kinase-like domain. Interaction with glycophorin C (GPC) and 4.1R suggests that p55 may play a role in the dynamic regulation in the erythrocyte membrane. In addition, p55 gene expression in vivo may be associated with a CpG island. P55 is constitutively expressed in K562 erythroleukemia cells during erythropoiesis and undergoes a 2-fold amplification after induction.
Image Unavailable-10487-480

Anti-VPRBP Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10487-480)
Supplier: Bioss
Description: P55 is an extensively palmitoylated erythrocyte membrane protein, and a member of the MAGUK family. P55 also resists salt extraction, resulting in a high affinity for the plasma membrane. P55 contains a PDZ/DHR domain, a conserved SH-3 domain that appears to suppress tyrosine kinase activity of various oncoproteins, a 39-amino acid motif that binds to cytoskeletal protein 4.1R, and a guanylate kinase-like domain. Interaction with glycophorin C (GPC) and 4.1R suggests that p55 may play a role in the dynamic regulation in the erythrocyte membrane. In addition, p55 gene expression in vivo may be associated with a CpG island. P55 is constitutively expressed in K562 erythroleukemia cells during erythropoiesis and undergoes a 2-fold amplification after induction.
Image Unavailable-103009-502

[Lys(Me3)27-Histone H3 (23-34)-GGK,Biotin

Catalog Number: (103009-502)
Supplier: Anaspec Inc
Description: This is histone H3 (23-34) trimethylated at Lys27 and biotinylated on the C-terminus through a GGK linker. Trimethylation of Lys27 promotes Polycomb protein (Pc)-chromatin association. This modification has also been shown to be associated with methylated CpG island genes in cancer cells. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Sequence:KAAR-K(Me3)-SAPATGG-GGK(Biotin)
MW:1624.9 Da
% peak area by HPLC:95
Storage condition:-20° C
Image Unavailable-89297-302

Anti-MBD2 Goat Polyclonal Antibody

Catalog Number: (89297-302)
Supplier: Genetex
Description: Goat polyclonal antibody to MBD2 (isoform 1)
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