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Product Image-10748-900

Anti-IFIT1 Rabbit Polyclonal Antibody

Catalog Number: (10748-900)
Supplier: Prosci
Description: The interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides. These proteins have been suggested to induce anti-viral cellular activities in response to infection. Together with the interferon-induced transmembrane protein 1 (IFITM1), IFIT1 inhibits the replication of the Hepatitis C virus, suggesting that it may be useful in the development of therapeutic treatments.
Product Image-10748-896

Anti-UBIAD1 Rabbit Polyclonal Antibody

Catalog Number: (10748-896)
Supplier: Prosci
Description: The UbiA prenyltransferase domain containing 1 (UBIAD1) protein , also known as TERE1, was initially identified as a down-regulated gene in transitional cell carcinoma of the bladder. Recently it has been shown to bind the cholesterol carrier APOE and modulate cellular cholesterol levels. Mutations in the UBIAD1 gene can cause Schnyder crystalline corneal dystrophy, an autosomal dominant disease characterized by progressive opacification of the cornea resulting from the local accumulation of lipids.
Product Image-10748-968

Anti-PDCL3 Rabbit Polyclonal Antibody

Catalog Number: (10748-968)
Supplier: Prosci
Description: Phosducin-like proteins (PhLPs) are a conserved family of proteins with thioredoxin-like domains that were initially identified as modulators of G protein signaling. PDCL3 is highly homologous to PDCL and shares an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. Along with the related protein PDCL2, PDCL3 interacts with the chaperonin CCT and modulates CCT-mediated actin and tubulin folding. Modulation of PDCL3 levels by MAPK phosphorylation and RhoA-dependent changes also promote cytoskeletal remodeling.
Product Image-10061-854

Anti-MTERF4 Rabbit Polyclonal Antibody

Catalog Number: (10061-854)
Supplier: Prosci
Description: MTERFD2 Antibody: Members of the mTERF (mitochondrial transcription termination factor) family, are mitochondrial proteins that are believed to be transcription termination factors. MTERFD2 is targeted to the mitochondria and is ubiquitously expressed, with highest expression levels in fore- and midbrain, diencephalon, spinal cord, tongue, lung liver and kidney. MTERFD2 has been suggested to play a role in organ differentiation during embryogenesis. A closely related mTERF family member, MTERFD3, is believed to be involved in cell cycle regulation and cell growth by modulating mitochondrial transcription.
Product Image-10062-048

Anti-ARR3 Rabbit Polyclonal Antibody

Catalog Number: (10062-048)
Supplier: Prosci
Description: Arrestin 3 (ARR3) belongs to the Arrestin family of proteins that function as negative regulators of G protein-coupled receptor (GPCR) signaling (1,2). ARR3 binds the c-Jun N-terminal kinase 3 (JNK3) and scaffolds the apoptosis signal-regulating kinase 1 (ASK1)-MAPK kinase4-JNK3 cascade in a receptor-independent fashion, promoting JNK3 phosphorylation. ARR3 also mediates the internalization of the C-C chemokine receptor CCR7 upon the binding of its ligand CCL19, but not CCL21, suggesting that it helps mediate CCR7 receptor desensitization.
Product Image-10749-532

Anti-AICDA Rabbit Polyclonal Antibody

Catalog Number: (10749-532)
Supplier: Prosci
Description: AID Antibody: Activation-induced cytidine deaminase (AID) was initially discovered as a homolog of the apolipoprotein B RNA-editing cytidine deaminase 1 (APOBEC1) that showed cytidine deaminase properties in stimulated B cell lines. It is necessary for somatic hypermutation and class switch recombination in B cells, but inappropriate or dysregulated expression AID is often found in tumors and B cell neoplasms. Although it is structurally and functionally similar to the APOBEC proteins, it appears unlikely that AID deaminates dC to dU residues in HIV cDNA as does APOBEC3G.
Product Image-10750-074

Anti-FBXL20 Rabbit Polyclonal Antibody

Catalog Number: (10750-074)
Supplier: Prosci
Description: SCRAPPER Antibody: Members of the F-box protein family, such as Scrapper, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin, and F-box proteins, act as protein-ubiquitin ligases. Scrapper is selectively expressed in the brain, broadly expressed within the mouse CNS and is abundant at presynaptic membrane. Scrapper has orthologs in C. elegans, D. melanogaster, and mammals which suggests that it might function as an important membrane-localized E3 ligase in various species. Scrapper is a major presynaptic E3 ubiquitin ligase that acts through RIM1a via degradation and the ubiquitin-proteasome-system (UPS) pathway to critically regulate synaptic transmission. This identifies protein degradation as a mechanism for holding synaptic communication in check.
Product Image-10749-676

Anti-EIF4EBP1 Rabbit Polyclonal Antibody

Catalog Number: (10749-676)
Supplier: Prosci
Description: 4E-BP1 Antibody: The translation of mRNA in eukaryotic cells is regulated by the presence of amino acids through multiple mechanisms. One such mechanism involves the evolutionarily conserved serine/threonine kinase TOR (Target of rapamycin, also known as mTOR), which regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. One downstream target of TOR is the eukaryotic initiation factor 4E binding protein 1 (4E-BP1) whose phosphorylation prevents its association with eIF4E, preferentially stimulating translation of mRNAs containing long, highly structured 5'-UTRs. Rapamycin inhibits TOR resulting in reduced cell growth and reduced rates of cell cycle and cell proliferationl, at least in part by inhibiting the activity of TOR towards 4E-BP1.
Product Image-10751-798

Anti-NEUROG2 Rabbit Polyclonal Antibody

Catalog Number: (10751-798)
Supplier: Prosci
Description: NGN2 Antibody: Neurogenin-2 (NGN2) is a neural-specific basic helix-loop-helix (bHLH) transcription factor that can specify a neuronal fate on ectodermal cells and is expressed in neural progenitor cells within the developing central and peripheral nervous systems. NGN2 is thought to work with Nurr1 to play a role in the differentiation and survival of midbrain dopaminergic neurons. It has also been suggested for use in human embryonic neural progenitors as a graft for spinal cord injuries
Product Image-89417-016

Anti-PTER Rabbit Polyclonal Antibody

Catalog Number: (89417-016)
Supplier: Prosci
Description: PTER Antibody: PTER is a mammalian homolog to bacterial phosphotriesterases, enzymes that hydrolyze phosphotriester-containing organophosphate pesticides. It is expressed primarily in the proximal renal tubules and the gene has been localized in humans to chromosomal band 10p12 by in situ hybridization. PTER, in addition to FTO, MC4R, and NPC1 has recently been shown to be a new risk loci for early-onset and morbid adult obesity in European populations. At least two isoforms of PTER are known to exist.
Product Image-89417-382

Anti-LYRM2 Rabbit Polyclonal Antibody

Catalog Number: (89417-382)
Supplier: Prosci
Description: LYRM2 Antibody: The Lyr motif found in the LYR-motif containing protein family is similar to that found in the sacchromyces cerevisiae protein ISD11, an iron-sulfur protein in the mitochondria that is thought to play a role in iron homeostasis. No known function has been assigned to LYRM2, although LYRM1 is thought to be involved in preadipocyte progression and LYRM3 has been suggested to be a candidate gene for the branchio-oto-renal (BOR) syndrome.
Product Image-10750-878

Anti-WDR74 Rabbit Polyclonal Antibody

Catalog Number: (10750-878)
Supplier: Prosci
Description: NSA1 Antibody: The yeast nucleolar protein NOP7 is necessary for the maturation of 66S preribosomes and interacts with numerous other proteins. One such protein is an essential, conserved WD repeat protein, NOP seven-associated protein 1 (NSA1), that is also required for the yeast 66S ribosome assembly. NSA1 is also associated with the AAA ATPase Rix7, and release of NSA1 from a novel late nucleolar pre-60S requires the Rix7 function. NSA1 has also been found upregulated in mammalian cancer cells, suggesting it may also play a role in cell proliferation.
Product Image-10751-470

Anti-PRICKLE1 Rabbit Polyclonal Antibody

Catalog Number: (10751-470)
Supplier: Prosci
Description: PRICKLE1 Antibody: PRICKLE1, also known as RILP or EPM1B, is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4 (1, 2). It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.
Product Image-10750-144

Anti-UNC93A Rabbit Polyclonal Antibody

Catalog Number: (10750-144)
Supplier: Prosci
Description: Unc93a Antibody: Unc93a, a human homolog of the C. elegans Unc93 gene, was initially identified by the sequencing of chromosome 6q27 at D6S193 as loss at this region correlated with sporadic ovarian cancer. Further analysis however, showed no tumor suppressor role for Unc93a. Unlike Unc93b, another homolog of the C. elegans Unc93 gene that is crucial for Toll-like receptor (TLR) signaling, the function of Unc93a is unknown. It is expressed in testis, small intestine, spleen, prostate and ovary.
Product Image-10751-346

Anti-MEIG1 Rabbit Polyclonal Antibody

Catalog Number: (10751-346)
Supplier: Prosci
Description: MEIG1 Antibody: MEIG1, a murine gene first identified as a testis specific gene, is a chromosome/chromatin-binding protein initially expressed during meiosis but retained in the germ cell nucleus throughout later stages of spermatogenesis. MEIG1 is a highly conserved basal metazoan gene that is indispensable for mouse spermatogenesis. It is important for normal meiotic differentiation and absolutely crucial for terminal differentiation of spermatozoa. MEIG1 encodes two alternative transcripts, designated 2a2 and 11a2, both of which encode for a common ORF but differing in their 5' untranslated region (5'UTR) due to alternative promoters.
Product Image-10751-734

Anti-DLK1 Rabbit Polyclonal Antibody

Catalog Number: (10751-734)
Supplier: Prosci
Description: DLK1 Antibody: The Delta-like 1 homolog (DLK1) is a transmembrane protein containing six epidermal growth factor repeats. It is involved in the differentiation of several cell types, including adipocytes and is also thought to be a tumor suppressor. The DLK1 gene is one of several imprinted genes located in a region on chromosome 14q32; certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). DLK1 is expressed from the paternal allele; a polymorphism within this gene has been associated with child and adolescent obesity.
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