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5(6)-Carboxy-X-rhodamine triethylammonium salt ≥98% (by TLC) amine-reactive fluorescent dye

Catalog Number: (89139-522)
Supplier: Biotium
Description: 5(6)-ROX (full name: 5-(and-6)-Carboxy-X-rhodamine, triethylammonium salt (mixed isomers)) is a long wavelength rhodamine dye.
Product Image-89417-780

Anti-CTTNBL1 Rabbit Polyclonal Antibody

Catalog Number: (89417-780)
Supplier: Prosci
Description: CTTNBL1 Antibody: The Beta-catenin-like protein 1 (CTNNBL1) contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs, as well as Armadillo/beta-catenin-like repeats. Transient expression of CTNNBL1 resulted in translocation to the nucleus and apoptosis, suggesting it may be involved in the apoptotic pathway. CTNNBL1 interacts with the Prp19 complex of the spliceosome and the Ig class switching enzyme activation-induced deaminase (AID) and had been suggested to play a role in antibody-diversification and class switching, but recent studies have shown CTNNBL1 to be dispensable for Ig class switch recombination. Other studies have identified CTTNBL1 as a novel gene for obesity.
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3-Carboxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl ≥97% free radical

Supplier: Thermo Scientific Chemicals
Description: 3-Carboxy-2,2,5,5-tetramethylpyrrolidine-1-oxyl ≥97% free radical

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Image Unavailable-89139-526

5-Carboxy-X-rhodamine triethylammonium salt single isomer ≥98% (by TLC) amine-reactive fluorescent dye

Catalog Number: (89139-526)
Supplier: Biotium
Description: 5-ROX (full name: 5-Carboxy-X-rhodamine, triethylammonium salt, single isomer) is a single isomer, long wavelength rhodamine dye.
Product Image-89417-774

Anti-ZNF346 Rabbit Polyclonal Antibody

Catalog Number: (89417-774)
Supplier: Prosci
Description: ZNF346 (CT) Antibody: ZNF346, also known as JAZ (just another zinc-finger protein), is a nucleolar, zinc finger protein which preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids with high affinity via C2H2 zinc fingers. ZNF346 contains four CH-type zinc finger motifs that are connected by long (28-38) amino acid linker sequences. ZNF346 is expressed in all tissues tested and localizes to the nucleus, primarily the nucleolus. ZNF346 is exported by exportin-5 but translocates back into nuclei by a facilitated diffusion mechanism. ZNF346 interacts with ILF3 in an RNA-independent manner and may be involved in cell growth and survival.
Product Image-89165-976

5(6)-Carboxy-2′,7′- dichlorofluorescein diacetate ≥98% (by HPLC), Ultrapure

Catalog Number: (89165-976)
Supplier: Enzo Life Sciences
Description: pH indicator
Product Image-10061-830

Anti-RRAS2 Rabbit Polyclonal Antibody

Catalog Number: (10061-830)
Supplier: Prosci
Description: RRAS2 Antibody: Activating mutations and overexpression of classical Ras subfamily members (K-RAS, N-RAS and H-RAS) have been widely investigated as key events in the development of human cancers. The RRAS subfamily of Ras-related proteins includes RRAS1, RRAS2 (TC21) and RRAS3 (M-Ras) show overall amino acid identity with the classical Ras subfamily (H-Ras, K-Ras and N-Ras) of 55–60%. RRAS2 is a small GTPbinding protein of the Ras superfamily of GTPases. It might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins. RRAS2 has high oncogenic potential and overexpression/mutations have been reported in several tumor tissues and cell lines.
Product Image-89416-628

Anti-LIMP2 Rabbit Polyclonal Antibody

Catalog Number: (89416-628)
Supplier: Prosci
Description: LIMP2 Antibody: The lysosomal integral membrane protein 2 (LIMP2) is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP2 in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP2 was shown to act as a receptor to bind beta-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP2-deficient mice showed missorted as well as secreted beta-glucocerebrosidase, suggesting that LIMP2 also functions as the mannose-6-phosphate-independent trafficking receptor.
Product Image-89417-506

Anti-IDH1 Rabbit Polyclonal Antibody

Catalog Number: (89417-506)
Supplier: Prosci
Description: IDH1 Antibody: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. The presence of IDH1 in peroxisomes suggests it may play a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic IDH1 serves a significant role in cytoplasmic NADPH production. Defects in IDH1 are involved in the development of glioma.
Product Image-89416-356

Anti-TRIM25 Rabbit Polyclonal Antibody

Catalog Number: (89416-356)
Supplier: Prosci
Description: TRIM25 Antibody: TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.
Product Image-10748-900

Anti-IFIT1 Rabbit Polyclonal Antibody

Catalog Number: (10748-900)
Supplier: Prosci
Description: The interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) protein is a member of a family of tetratricopeptide repeat-containing proteins whose transcription is upregulated by interferons, virus infection, and molecular patterns such as dsRNA or lipopolysaccharides. These proteins have been suggested to induce anti-viral cellular activities in response to infection. Together with the interferon-induced transmembrane protein 1 (IFITM1), IFIT1 inhibits the replication of the Hepatitis C virus, suggesting that it may be useful in the development of therapeutic treatments.
Product Image-10748-896

Anti-UBIAD1 Rabbit Polyclonal Antibody

Catalog Number: (10748-896)
Supplier: Prosci
Description: The UbiA prenyltransferase domain containing 1 (UBIAD1) protein , also known as TERE1, was initially identified as a down-regulated gene in transitional cell carcinoma of the bladder. Recently it has been shown to bind the cholesterol carrier APOE and modulate cellular cholesterol levels. Mutations in the UBIAD1 gene can cause Schnyder crystalline corneal dystrophy, an autosomal dominant disease characterized by progressive opacification of the cornea resulting from the local accumulation of lipids.
Product Image-89417-572

Anti-APOA4 Rabbit Polyclonal Antibody

Catalog Number: (89417-572)
Supplier: Prosci
Description: ApoA4 Antibody: Apolipoprotein A4 (also known as ApoA-IV) is a plasma protein that is an O-linked glycoprotein after proteolytic processing. ApoA4 is a major constituent of HDL and it also can be found on the surface of newly synthesized chylomicrons. The physiological function of ApoA4 is not completely identified so far, but evidence from several in vitro studies indicate that this apolipoprotein is involved in several steps of the reverse cholesterol transport pathway, which transports cholesterol from peripheral cells back to the liver.
Product Image-89416-826

Anti-PIGY Rabbit Polyclonal Antibody

Catalog Number: (89416-826)
Supplier: Prosci
Description: PIG-Y Antibody: Glycosylphosphatidylinositol (GPI) lipid anchoring is an important post-translational modification of proteins that takes place in the endoplasmic reticulum. The synthesis of GPI is initiated by GPI-N-acetylglucosaminyltransferase (GPI-GnT), a complex of proteins including PIG-A, PIG-H, PIG-C, GPI1, and DPM2. PIG-Y, the mammalian homolog to yeast Eri1p, is also thought to be involved in the biosynthesis of GPI. The PIG-Y gene encodes two proteins, one of which arises from leaky scanning of the mRNA.
Product Image-89417-822

Anti-APOA1 Rabbit Polyclonal Antibody

Catalog Number: (89417-822)
Supplier: Prosci
Description: ApoA1 Antibody: Apolipoprotein A1 (ApoA1) is the major protein component of high density lipoprotein (HDL) in plasma, which is correlated with cardiovascular disease. ApoA1 is synthesized in the liver and small intestine and promotes cholesterol efflux from tissues to the liver for excretion. It is a cofactor for lecithin cholesterolacyltransferase (LCAT), the enzyme responsible for the formation of most plasma cholesteryl esters. Defects in ApoA1 are associated with HDL deficiency, Tangier disease, and systemic non-neuropathic amyloidosis.
Product Image-89417-226

Anti-FAM59B Rabbit Polyclonal Antibody

Catalog Number: (89417-226)
Supplier: Prosci
Description: FAM59B Antibody: FAM59B is related to the FAM59A protein (also known as GAREM). While little is known of the role of the FAM59B protein, FAM59A is a downstream molecule in the EGF signaling pathway and binds Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. Like FAM59A, FAM59B may play a role in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.
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