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Product Image-10748-882

Anti-TET2 Rabbit Polyclonal Antibody

Catalog Number: (10748-882)
Supplier: Prosci
Description: TET2, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. It is a candidate tumor suppressor gene reported to be mutated in approximately 14% of patients with JAK2V617F-positive myeloproliferative neoplasms , and can be mutated in other hematopoietic disorders such as myelodysplastic syndromes, acute myeloid leukemia, and chronic myelomonocytic leukemia. Analysis of the TET2 and JAK2 mutations in these neoplasms suggests that mutations in TET2 do not represent a predisposition for acquiring mutations in JAK2.
Product Image-10749-018

Anti-KLF17 Rabbit Polyclonal Antibody

Catalog Number: (10749-018)
Supplier: Prosci
Description: KLF17, also known as ZNF393, is a member of the Sp/KLF family of transcription factors. KLF17 binds to the promoter and negatively regulates the transcription of Id-1, a key metastasis regulator in breast cancer. Suppression of KLF17 promotes breast cancer cell invasion and epithelial-mesenchymal transition. Down-regulated KLF17 expression is also associated tumor invasion and poor prognosis in hepatocellular carcinoma, suggesting that the level of KLF17 expression can serve as a prognostic indicator.
Product Image-10750-364

Anti-PIGY Rabbit Polyclonal Antibody

Catalog Number: (10750-364)
Supplier: Prosci
Description: PIG-Y Antibody: Glycosylphosphatidylinositol (GPI) lipid anchoring is an important post-translational modification of proteins that takes place in the endoplasmic reticulum. The synthesis of GPI is initiated by GPI-N-acetylglucosaminyltransferase (GPI-GnT), a complex of proteins including PIG-A, PIG-H, PIG-C, GPI1, and DPM2. PIG-Y, the mammalian homolog to yeast Eri1p, is also thought to be involved in the biosynthesis of GPI. The PIG-Y gene encodes two proteins, one of which arises from leaky scanning of the mRNA.
Product Image-10751-136

Anti-LMBRD1 Rabbit Polyclonal Antibody

Catalog Number: (10751-136)
Supplier: Prosci
Description: LMBRD1 Antibody: LMBRD1, also known as NESI (nuclear export signal-interacting protein, is a lysosomal membrane protein that is thought be involved in the transport and metabolism of cobalamin. LMBRD1 was initially identified as interacting with the large form of the hepatitis delta antigen and may be required for the nucleocytoplasmic shuttling of the hepatitis delta virus. Mutations in this gene are associated with the vitamin B12 metabolism disorder termed, homocystinuria-megaloblastic anemia complementation type F (cblF).
Product Image-10062-006

Anti-ENHO Rabbit Polyclonal Antibody

Catalog Number: (10062-006)
Supplier: Prosci
Description: ADROPIN is a recently identified protein that has been implicated in the maintenance of energy homeostasis and insulin resistance. ADROPIN expression is regulated by energy status and dietary nutrient content and is altered by obesity and regulates the expression of hepatic lipogenic genes and adipose tissue peroxisome proliferator-activated receptor gamma (PPAR-gamma). ADROPIN levels increase with dietary fat content. ADROPIN has also been proposed to play a role in the regulation of endothelial function.
Image Unavailable-89139-580

5-Carboxy-X-rhodamine succinimidyl ester (5-ROX SE) amine-reactive fluorescent dye

Catalog Number: (89139-580)
Supplier: Biotium
Description: 5-ROX, SE (5-Carboxy-X-rhodamine, succinimidyl ester, single isomer) is the amine-reactive form of 5-carboxy-X-rhodamine single isomer.
Product Image-10062-002

Anti-AIMP1 Rabbit Polyclonal Antibody

Catalog Number: (10062-002)
Supplier: Prosci
Description: AIMP1 (Endothelial monocyte-activating polypeptide II, EMAP2) is a proinflammatory cytokine for monocytes and granulocytes. It is specifically induced by apoptosis and is involved in the control of angiogenesis, inflammation, and wound healing (1,2). AIMP1 was identified as one of three auxiliary factors of the mammalian aminoacyl tRNA synthetase (ARS) complex. It binds and facilitates the catalytic reaction of arginyl-tRNA synthetase. Recent studies show that CD23 plays an essential role in the AIMP1-induced immune response and might be a target in the treatment of inflammatory diseases.
Product Image-89415-330

Anti-MYD88 Rabbit Polyclonal Antibody

Catalog Number: (89415-330)
Supplier: Prosci
Description: MYD88 Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kappa B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
Product Image-10751-740

Anti-EPM2A Rabbit Polyclonal Antibody

Catalog Number: (10751-740)
Supplier: Prosci
Description: EPM2A Antibody: The Epilepsy, progressive myoclonus type 2A protein (EPM2A) is a dual-specificity phosphatase that associates with polyribosomes. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. EPM2A interacts with a number of proteins known to be involved in glycogen metabolism and has been shown to have robust phosphatase activity against a phosphorylated complex carbohydrate, suggesting that EPM2A may be involved in the regulation of glycogen metabolism.
Product Image-10752-174

Anti-CFTR Rabbit Polyclonal Antibody

Catalog Number: (10752-174)
Supplier: Prosci
Description: The cystic fibrosis transmembrane conductance regulator (CFTR) protein is a member of the ATP-binding cassette (ABC) transporter superfamily, and a member of the MRP subfamily that is involved in multi-drug resistance. CFTR functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorder cystic fibrosis, the most common, fatal, inherited disease of caucasian populations.
Product Image-10751-966

Anti-KAT5 Rabbit Polyclonal Antibody

Catalog Number: (10751-966)
Supplier: Prosci
Description: KAT5 Antibody: KAT5 belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and non-histone proteins. KAT5 has been shown to play a role in DNA repair and apoptosis and is thought to play an important role in signal transduction and autophagy.
Image Unavailable-89139-522

5(6)-Carboxy-X-rhodamine triethylammonium salt ≥98% (by TLC) amine-reactive fluorescent dye

Catalog Number: (89139-522)
Supplier: Biotium
Description: 5(6)-ROX (full name: 5-(and-6)-Carboxy-X-rhodamine, triethylammonium salt (mixed isomers)) is a long wavelength rhodamine dye.
Product Image-10061-830

Anti-RRAS2 Rabbit Polyclonal Antibody

Catalog Number: (10061-830)
Supplier: Prosci
Description: RRAS2 Antibody: Activating mutations and overexpression of classical Ras subfamily members (K-RAS, N-RAS and H-RAS) have been widely investigated as key events in the development of human cancers. The RRAS subfamily of Ras-related proteins includes RRAS1, RRAS2 (TC21) and RRAS3 (M-Ras) show overall amino acid identity with the classical Ras subfamily (H-Ras, K-Ras and N-Ras) of 55–60%. RRAS2 is a small GTPbinding protein of the Ras superfamily of GTPases. It might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins. RRAS2 has high oncogenic potential and overexpression/mutations have been reported in several tumor tissues and cell lines.
Product Image-89165-976

5(6)-Carboxy-2′,7′- dichlorofluorescein diacetate ≥98% (by HPLC), Ultrapure

Catalog Number: (89165-976)
Supplier: Enzo Life Sciences
Description: pH indicator
Product Image-89417-572

Anti-APOA4 Rabbit Polyclonal Antibody

Catalog Number: (89417-572)
Supplier: Prosci
Description: ApoA4 Antibody: Apolipoprotein A4 (also known as ApoA-IV) is a plasma protein that is an O-linked glycoprotein after proteolytic processing. ApoA4 is a major constituent of HDL and it also can be found on the surface of newly synthesized chylomicrons. The physiological function of ApoA4 is not completely identified so far, but evidence from several in vitro studies indicate that this apolipoprotein is involved in several steps of the reverse cholesterol transport pathway, which transports cholesterol from peripheral cells back to the liver.
Product Image-89416-826

Anti-PIGY Rabbit Polyclonal Antibody

Catalog Number: (89416-826)
Supplier: Prosci
Description: PIG-Y Antibody: Glycosylphosphatidylinositol (GPI) lipid anchoring is an important post-translational modification of proteins that takes place in the endoplasmic reticulum. The synthesis of GPI is initiated by GPI-N-acetylglucosaminyltransferase (GPI-GnT), a complex of proteins including PIG-A, PIG-H, PIG-C, GPI1, and DPM2. PIG-Y, the mammalian homolog to yeast Eri1p, is also thought to be involved in the biosynthesis of GPI. The PIG-Y gene encodes two proteins, one of which arises from leaky scanning of the mRNA.
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