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Image Unavailable-76121-120

Anti-C21orf91 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76121-120)
Supplier: Bioss
Description: First is a 297 amino acid protein that contains a putative carboxy-terminal coiled-coil domain. With highest expression in embryonic dorsal retina and, during later embryonic stages, the anterior epithelial cells of the lens, it is suspected that EURL may play a role in cell determination and differentiation. The gene encoding EURL maps to the long arm of chromosome 21, which houses approximately 300 genes and comprises nearly 1.5% of the human genome. Chromosome 21-associated disorders include Alzheimer's Disease, amyotrophic lateral sclerosis and, most notably, Down Syndrome (also known as trisomy 21).
Product Image-89419-676

Rift valley fever virus RVF virus Peptide (19 aa near C-terminus)

Catalog Number: (89419-676)
Supplier: Prosci
Description: Rift Valley Fever Virus peptide is used for blocking the activity of RVF virus antibody.
Product Image-10748-288

Anti-NOD2 Rabbit Polyclonal Antibody

Catalog Number: (10748-288)
Supplier: Prosci
Description: NOD2 Antibody: Apaf-1 and NOD1 are members of a new family, which are involved in the regulation of apoptosis and immune response. Each of them contains a caspase recruitment domain (CARD) and a nucleotide-binding oligomerization domain (NOD). A third member in this family was recently identified and designated NOD2. NOD2 interacts with RICK via a homophilic CARD-CARD interaction. NOD2 activates NF-kappa B, which is regulated by its carboxy-terminal leucine-rich repeat domain that acts as an intracellular receptor for components of bacteria. The variants of NOD2, either a frameshift or a missense, were associated with Crohn's disease that is a main type of chronic inflammatory bowel disease.
Product Image-10097-906

Anti-IGFBP3 Rabbit Polyclonal Antibody (Biotin)

Catalog Number: (10097-906)
Supplier: Prosci
Description: Insulin like growth factor binding protein 3 (IGF-BP3) is a member of the superfamily of insulin like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGF-BP) and at least four low affinity binding proteins referred to as IGF-BP related proteins (IGFBPrP). The IGF-BP members are cysteine rich proteins with conserved cysteine residues clustered in the amino terminal and the carboxy terminal regions of the molecule. The cDNA sequence encoding the mature human IGF-BP3 is fused to the signal peptide of CD33. Human IGF-BP3 is the major IGF binding protein in plasma where it exists in a ternary complex with IGFI or IGFII and an acid labile subunit.
Image Unavailable-10749-222

Anti-VCL Mouse Monoclonal Antibody [clone: 7E10]

Catalog Number: (10749-222)
Supplier: Prosci
Description: Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development. Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail. Expression of vinculin were shown to be affected by the level of actin expression. Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth. Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W).
Product Image-10751-630

Anti-NBN Rabbit Polyclonal Antibody

Catalog Number: (10751-630)
Supplier: Prosci
Description: NIBRIN Antibody: NIBRIN (NBN) is a member of the double-strand break repair complex MRE11/RAD50/NBN (MRN) which is involved in DNA double-strand break repair, DNA damage-induced checkpoint activation and plays a critical role in the maintenance of chromosome integrity. NIBRIN contains two modules found in cell cycle checkpoint proteins, a forkhead-associated domain adjacent to a breast cancer carboxy-terminal domain. Mutations in this gene are associated with Nijmegen breakage syndrome and maybe the cause of cancer predisposition and aplastic anemia.
Product Image-89415-226

Anti-CCL11 Rabbit Polyclonal Antibody

Catalog Number: (89415-226)
Supplier: Prosci
Description: Eotaxin Antibody: Chemokines play a key role in inflammation. The CC chemokine eotaxin is a potent and specific eosinophil chemoattractant that is expressed by a variety of cell types in certain inflammatory conditions. Some G-protein coupled chemokine receptors are also utilized as virus coreceptors for fusion and infection of cells. The eotaxin receptor CCR3 is required for HIV-1 entry into target cells such as microglia and eotaxin inhibits the infection of HIV-1.
Image Unavailable-10464-104

Anti-LPIN1 Rabbit Polyclonal Antibody

Catalog Number: (10464-104)
Supplier: Bioss
Description: Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Image Unavailable-10347-772

Anti-ASB2 Rabbit Polyclonal Antibody

Catalog Number: (10347-772)
Supplier: Bioss
Description: The ankyrin repeat and SOCS box containing (ASB) protein family is comprised of members which each contain "SOCS boxes" but differ from other families of protein in the motifs they contain upstream of the SOCS box. SOCS boxes are carboxy terminal regions of homology found in the suppressor of cytokine signaling family of proteins. The box region is thought to be the point of interaction between SOCS proteins and E3 ubiquitin ligases. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. The gene is induced by all trans retinoic acid. In myeloid leukemia cells, the expression of this encoded protein has been shown to induce growth inhibition and chromatin condensation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
Image Unavailable-TCD0944-001G

5,5'-Dithiobis(2-nitrobenzoic acid) (Ellmans reagent, DTNB) ≥98.0% (by HPLC, titration analysis)

Supplier: TCI America
Description: [for Determination of SH groups]
CAS Number: 69-78-3
MDL Number: MFCD00007140
Molecular Formula: C14H8N2O8S2
Molecular Weight: 396.34
Purity/Analysis Method: >98.0% (HPLC,T)
Form: Crystal

SDS Certificates

Image Unavailable-10425-348

Anti-ADAMTSL2 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10425-348)
Supplier: Bioss
Description: ADAMTS (A Disintegrin And Metalloproteinase Domain with Thrombospondin type 1 Modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of Thrombospondin type 1 (TSP-1) motifs. ADAMTS-L2 (ADAMTS-like protein 2) is a 951 amino acid secreted protein that is highly expressed in lung, kidney and liver. Mutations in the gene encoding ADAMTS are the cause of geleophysic dysplasia, an autosomal recessive disorder characterized by cardiac vavular anomalies, short stature, thick skin and brachydactyly. In individuals affected with geleophysic dysplasia, there is a significant increase in total active TGF-beta 1 and nuclear locations of p-SAMD2 in fibroblasts. Interestingly, ADAMTS-L2 interacts with LTBP-1, a glycoprotein that is part of the platelet-derived TGF-beta 1 complex.
Image Unavailable-10425-344

Anti-ADAMTSL2 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10425-344)
Supplier: Bioss
Description: ADAMTS (A Disintegrin And Metalloproteinase Domain with Thrombospondin type 1 Modules) is a family of zinc-dependent proteases that are implicated in a variety of normal and pathological conditions, including arthritis and cancer. ADAMTS protein family members contain an amino-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain and a carboxy-terminus that contains a varying number of Thrombospondin type 1 (TSP-1) motifs. ADAMTS-L2 (ADAMTS-like protein 2) is a 951 amino acid secreted protein that is highly expressed in lung, kidney and liver. Mutations in the gene encoding ADAMTS are the cause of geleophysic dysplasia, an autosomal recessive disorder characterized by cardiac vavular anomalies, short stature, thick skin and brachydactyly. In individuals affected with geleophysic dysplasia, there is a significant increase in total active TGF-beta 1 and nuclear locations of p-SAMD2 in fibroblasts. Interestingly, ADAMTS-L2 interacts with LTBP-1, a glycoprotein that is part of the platelet-derived TGF-beta 1 complex.
Product Image-89416-780

Anti-RKHD4 Rabbit Polyclonal Antibody

Catalog Number: (89416-780)
Supplier: Prosci
Description: Rkhd4 Antibody: Rkhd4, also known as MEX3A is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd4, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. While Rkhd2 has been suggested to be associated with susceptibility to essential hypertension type 8, the function of Rkhd4 remains unknown. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
Image Unavailable-10464-122

Anti-LPIN1 Rabbit Polyclonal Antibody (Cy7®)

Catalog Number: (10464-122)
Supplier: Bioss
Description: Lipin 1 is a member of the Lipin family of nuclear proteins. This family contains three members: Lipin 1, Lipin 2 and Lipin 3, all of which contain a nuclear signal sequence, a highly conserved amino-terminal (NLIP) domain and a carboxy-terminal (CLIP) domain. LPIN1 (Lipin 1) is crucial for normal adipose tissue development and metabolism. LPIN1 selectively activates a subset of PGC1 alpha target pathways, including fatty acid oxidation and mitochondrial oxidative phosphorylation by inducing expression of the nuclear receptor PPARalpha. LPIN1 also inactivates the lipogenic program and suppresses circulating lipid levels. An abundance of LPIN1 promotes fat accumulation and insulin sensitivity, whereas a deficiency in LPIN1 may deter normal adipose tissue development, resulting in insulin resistance and lipodystrophy, a heterogeneous group of disorders characterized by loss of body fat, fatty liver, hypertriglyceridemia and insulin resistance.
Product Image-10752-084

Anti-ZNF821 Rabbit Polyclonal Antibody

Catalog Number: (10752-084)
Supplier: Prosci
Description: The ZNF821 protein contains two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. The exact function of ZNF821, however, remains unknown.
Image Unavailable-10480-078

Anti-CTDSPL2 Rabbit Polyclonal Antibody (Cy3®)

Catalog Number: (10480-078)
Supplier: Bioss
Description: CTDSPL2 (CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2), also known as HSPC058 or HSPC129, is a 466 amino acid protein that contains one FCP1 homology domain and belongs to the CTDSPL2 family. Existing as two alternatively spliced isoforms, CTDSPL2 is thought to function as a phosphatase and is encoded by a gene that maps to human chromosome 15q15.3. Encoding more than 700 genes, chromosome 15 is made up of approximately 106 million base pairs and comprises about 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.
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