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Description: The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.MMP17 has been reported to be elevated in several tumor cell lines, and is constituitively produced by some normal cell lines. Treatment of cells with Concanavolin A or the phorbol ester TPA stimulates production of MMP17 in some cell types, and the enzyme can be recovered in cell lysates. Shed forms of MMP17 have also been reported.

Catalog Number: 76101-102

Supplier: Bioss

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Description: The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.MMP17 has been reported to be elevated in several tumor cell lines, and is constituitively produced by some normal cell lines. Treatment of cells with Concanavolin A or the phorbol ester TPA stimulates production of MMP17 in some cell types, and the enzyme can be recovered in cell lysates. Shed forms of MMP17 have also been reported.

Catalog Number: 76101-104

Supplier: Bioss

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Description: Sandwich ELISA kit of Quantitative Detection for Mouse MMP-3

Catalog Number: 10207-788

Supplier: Boster Biological Technology

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Description: Powder

Catalog Number: CAAAJ60982-MC

Supplier: Thermo Scientific Chemicals

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Description: Anti-Serine protease inhibitor Kazal-type 2-like protein Rabbit Polyclonal Antibody

Catalog Number: 77712-615

Supplier: AFG Bioscience

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Description: Anti-Trypsin inhibitor DE-3 Rabbit Recombinant Polyclonal Antibody

Catalog Number: 77817-611

Supplier: AFG Bioscience

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Description: Rabbit monoclonal [EPR20165-84] to C1 inhibitor - BSA and Azide free (Detector).

Catalog Number: ABCA_AB244940-1MG

Supplier: Abcam

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Description: Sandwich ELISA kit of Quantitative Detection for Human MMP-9

Catalog Number: 10207-794

Supplier: Boster Biological Technology

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Description: Human Inhibitor of Nuclear Factor Kappa-B Kinaseα(IKK-α) ELISA Kit

Catalog Number: 76714-460

Supplier: AFG Bioscience

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Description: Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels. Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Catalog Number: 10403-732

Supplier: Bioss

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Description: Synthetic peptides that irreversibly inhibit the activity of each of the caspase-family proteases. YVAD is the recognition sequence for caspase-1/ICE, DEVD is the recognition sequence for caspase-3/CPP32, VEID is the recognition sequence for caspase-6/Mch2, IETD is the recognition sequence for caspase-8/ FLICE, and VAD is the recognition sequence for a caspase(s) that functions upstream of most other caspases.   

Catalog Number: 89155-992

Supplier: Enzo Life Sciences

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Description: Rabbit monoclonal [EPR20165-39] to C1 inhibitor - BSA and Azide free (Capture).

Catalog Number: ABCA_AB244675-1MG

Supplier: Abcam

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Description: Bon Opus Biosciences offers quality recombinant proteins products covering a broad collection of cytokines, enzymes, diagnostic and detection reagents, and other protein-related products

Catalog Number: 102497-896

Supplier: Bon Opus Biosciences

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Description: gamma-Secretase Inhibitor

Catalog Number: CAAAJ64068-LB0

Supplier: Thermo Scientific Chemicals

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Description: Sandwich ELISA kit of Quantitative Detection for Human MMP-12

Catalog Number: 10207-704

Supplier: Boster Biological Technology

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Description: Sandwich ELISA kit of Quantitative Detection for Mouse MMP-9

Catalog Number: 10207-796

Supplier: Boster Biological Technology

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