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Image Unavailable-76078-562

Anti-CDO1 Rabbit Polyclonal Antibody (Alexa Fluor® 680)

Catalog Number: (76078-562)
Supplier: Bioss
Description: CDO1 (cysteine dioxygenase, type I) is a 200 amino acid protein that belongs to the cysteine dioxygenase family and is involved in organosulfur biosynthesis. Existing as a monomer and expressed at high levels in liver and placenta and at lower levels in brain, pancreas and heart, CDO1 functions as a dioxygenase that uses iron and zinc as cofactors to catalyze the conversion of L-cysteine and oxygen to 3-sulfinoalanine. Via its catalytic activity, CDO1 is involved in pyruvate-, sulfate- and taurine-related metabolic pathways and is a crucial regulator of cysteine concentrations within the cell. Human CDO1 shares 94% amino acid identity with its rat counterpart, suggesting a conserved role between species. The gene encoding CDO1 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.PathwayOrganosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Product Image-76180-248

Heavy-Duty Guard Rail Carts, AmTab

Catalog Number: (76180-248)
Supplier: AmTab Manufacturing Corporation
Description: These heavy-duty guard rail carts are used every day in conjunction with our stage units. High-quality state-of-the-art guard rail carts are safe, durable, easy to operate, and perfect for heavy-use and heavy-turn settings providing years of trusted service.

Environmentally Preferable


Image Unavailable-TCB2711-1G

1,1'-Bis(di-tert-butylphosphino)ferrocene ≥95.0% (by titrimetric analysis)

Supplier: TCI America
Description: CAS Number: 84680-95-5
Molecular Formula: C26H44FeP2
Molecular Weight: 474.43
Purity/Analysis Method: >95.0% (T)
Form: Crystal
Melting point (°C): 182

SDS Certificates

Image Unavailable-10341-082

Anti-CD163 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10341-082)
Supplier: Bioss
Description: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Image Unavailable-10424-048

Anti-CDO1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (10424-048)
Supplier: Bioss
Description: CDO1 (cysteine dioxygenase, type I) is a 200 amino acid protein that belongs to the cysteine dioxygenase family and is involved in organosulfur biosynthesis. Existing as a monomer and expressed at high levels in liver and placenta and at lower levels in brain, pancreas and heart, CDO1 functions as a dioxygenase that uses iron and zinc as cofactors to catalyze the conversion of L-cysteine and oxygen to 3-sulfinoalanine. Via its catalytic activity, CDO1 is involved in pyruvate-, sulfate- and taurine-related metabolic pathways and is a crucial regulator of cysteine concentrations within the cell. Human CDO1 shares 94% amino acid identity with its rat counterpart, suggesting a conserved role between species. The gene encoding CDO1 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.PathwayOrganosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Image Unavailable-76078-564

Anti-CDO1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76078-564)
Supplier: Bioss
Description: CDO1 (cysteine dioxygenase, type I) is a 200 amino acid protein that belongs to the cysteine dioxygenase family and is involved in organosulfur biosynthesis. Existing as a monomer and expressed at high levels in liver and placenta and at lower levels in brain, pancreas and heart, CDO1 functions as a dioxygenase that uses iron and zinc as cofactors to catalyze the conversion of L-cysteine and oxygen to 3-sulfinoalanine. Via its catalytic activity, CDO1 is involved in pyruvate-, sulfate- and taurine-related metabolic pathways and is a crucial regulator of cysteine concentrations within the cell. Human CDO1 shares 94% amino acid identity with its rat counterpart, suggesting a conserved role between species. The gene encoding CDO1 maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.PathwayOrganosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2.
Product Image-76180-418

Heavy-Duty Stage Ramp Carts, AmTab

Supplier: AmTab Manufacturing Corporation
Description: Heavy-duty stage ramp carts are used every day in conjunction with our stage and stage ramp units. High-quality state-of-the-art guard rail carts are safe, durable, easy to operate, and a great long-term value. Carts are perfect for heavy-use and heavy-turn settings providing years of trusted service.

Environmentally Preferable

Product Image-58958-540

Accessories for Power-Stir® High-Torque Overhead Stirrer, Eberbach

Supplier: Eberbach
Description: Agitator — Stainless steel blades are riveted onto 6.3 mm (<sup>1</sup>/<sub>4</sub>") shafts. Pitch of blade can be varied to control degree of agitation. Creates downward thrust when rotated in clockwise direction. The 46 cm (18") and 61 cm (24") shaft lengths are recommended for hollow spindle stirrers.

Product Image-CA97021-786

Fluoride Ionic Strength Adjustor (ISA) Powder Pillows, Hach

Catalog Number: (CA97021-786)
Supplier: Hach
Description: Fluoride Total Ionic Strength Adjustor Buffer (TISAB) for use when making fluoride determinations by electrode methods

SDS


Product Image-10798-130

Human Recombinant Erythropoietin (from HEK293 cells)

Catalog Number: (10798-130)
Supplier: Prosci
Description: Human Erythropoietin (EPO) is also known as EP, erythropoetin or erthropoyetin, and is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. EPO is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow. is synthesized by renal peritubular cells in adults, with a small amount being produced in the liver. Regulation is believed to rely on a feed-back mechanism measuring blood oxygenation. Constitutively synthesized transcription factors for EPO, known as hypoxia-inducible factors (HIFs), are hydroxylated and proteosomally digested in the presence of oxygen. It binds to the erythropoietin receptor (EpoR) on the red cell surface and activates a JAK2 cascade. Erythropoietin has its primary effect on red blood cells by promoting red blood cell survival through protecting these cells from apoptosis. It also cooperates with various growth factors involved in the development of precursor red cells. EPO has a range of actions including vasoconstriction-dependent hypertension, stimulating angiogenesis, and inducing proliferation of smooth muscle fibers. It has also been shown that erythropoietin can increase iron absorption by suppressing the hormone hepcidin. Erythropoietin has been shown to interact with the Erythropoietin receptor as its mechanism of action within the body. erythropoietin plays an important role in the brain's response to neuronal injury. EPO is also involved in the wound healing process.
Product Image-CA11016-852

Fluoride Ionic Strength Adjustor (ISA), 3.78 L, Hach

Catalog Number: (CA11016-852)
Supplier: Hach
Description: Fluoride Total Ionic Strength Adjustor Buffer Solution (TISAB) for fluoride determinations by electrode methods

SDS


Image Unavailable-75918-988

Anti-TFRC Mouse Monoclonal Antibody (CF405S) [clone: TFRC/1059]

Supplier: Biotium
Description: This antibody recognizes a ~90-95 kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190 kDa. This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Its epitope is localized in the extracellular domain of CD71. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Image-CAPI17892

EDTA disodium salt dihydrate, Pierce™

Catalog Number: (CAPI17892)
Supplier: Thermo Scientific
Description: Thermo Scientific Pierce EDTA is useful as a chelator of alkaline earth metals, as well as iron, copper and zinc in a variety of laboratory methods.

SDS Certificates


Product Image-CA77578-272

Specialty Cell Culture Media

Supplier: Custom Comfort
Description: Serum-free media provide better control over the physiological condition of cultures while allowing simplified purification and downstream processing protocols

Certificates

Image Unavailable-76118-246

Anti-15 Lipoxygenase 1 Rabbit Polyclonal Antibody (Alexa Fluor® 750)

Catalog Number: (76118-246)
Supplier: Bioss
Description: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass.
Product Image-89417-760

Anti-OGFOD2 Rabbit Polyclonal Antibody

Catalog Number: (89417-760)
Supplier: Prosci
Description: OGFOD2 Antibody: OGFOD2 is a member of the 2-OG-Fe(II) dioxygenase family which plays an important role in ischemic survival and stress. Like the related protein OGFOD1, OGFOD2 is an oxidoreductase containing a Prolyl 4-hydroxylase alpha subunit. Little is known about the function of OGFOD2, but its similarity to OGFOD1 suggests that it is a novel stress granule component that may play an important proapoptotic role in the regulation of translation and HRI-mediated phosphorylation of eIF2alpha in cells.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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