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Catalog Number: (TCS0835-100MG)
Supplier: TCI America
Description: CAS Number: 152-95-4
MDL Number: MFCD01075138
Molecular Formula: C21H20O10
Molecular Weight: 432.38
Purity/Analysis Method: >98.0% (HPLC)
Form: Crystal
Color: Pale Yellow
Melting point (°C): 297
Specific rotation [a]20/D: -18 deg (C=1, Pyridine)
Lambda max.: 271 nm (MeOH)

Supplier: MilliporeSigma
Catalog Number: (10375-296)
Supplier: Bioss
Description: SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival.


Supplier: TCI America
Description: [for Biochemical Research]
CAS Number: 7240-90-6
MDL Number: MFCD00005666
Molecular Formula: C14H15BrClNO6
Molecular Weight: 408.63
Purity/Analysis Method: >98.0% (HPLC,N)
Form: Crystal
Specific rotation [a]20/D: -66 deg (C=1, DMF)
Storage Temperature: <0°C
Catalog Number: (CA8.14345.0050)
Supplier: MilliporeSigma

Catalog Number: (TCN0571-001G)
Supplier: TCI America
Description: CAS Number: 13133-07-8
MDL Number: MFCD00191672
Molecular Formula: C24H42O21
Molecular Weight: 666.58
Purity/Analysis Method: >99.0% (HPLC)
Form: Crystal
Specific rotation [a]20/D: 10 deg (C=4, H2O)

Catalog Number: (19757-082)
Supplier: Saf-T-Cart
Description: For transporting gas cylinders easily and safely


Supplier: Thermo Scientific Chemicals
Description: α-Bromo-4-chlorotoulene 98+%
Catalog Number: (76079-978)
Supplier: Bioss
Description: This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009].


Catalog Number: (10351-598)
Supplier: Bioss
Description: This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009].


Catalog Number: (10411-186)
Supplier: Bioss
Description: This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009].


Supplier: Thermo Scientific Chemicals
Description: α-Bromo-o-toluonitrile 98%
Supplier: Thermo Scientific Chemicals
Description: MDL: MFCD00000173 Beilstein Registry No.: 971015
Catalog Number: (10346-586)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.


Catalog Number: (10346-590)
Supplier: Bioss
Description: PDK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase and the stimulation of glycogen synthesis. Because of the role that PDK plays in insulin-induced glycogen synthesis and PKC activation it is a potentially important target for metabolic drug research. There are three named isoforms.


Catalog Number: (TCP1753-5G)
Supplier: TCI America
Description: CAS Number: 375-88-2
MDL Number: MFCD00013570
Molecular Formula: C7BrF15
Molecular Weight: 448.96
Purity/Analysis Method: >98.0% (GC)
Form: Clear Liquid
Color: Colorless
Boiling point (°C): 118
Specific Gravity (20/20): 1.92

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