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Image Unavailable-10072-846

Human Recombinant IL20 (from E. coli)

Catalog Number: (10072-846)
Supplier: Prosci
Description: IL-20 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20R-α and type II IL-20R-β. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Recombinant human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains.
Image Unavailable-10779-762

Human Recombinant IL-22 (from E. coli)

Supplier: Peprotech
Description: IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10Rβ/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant Human IL-22 is a 33.6 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.

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Image Unavailable-CAPI88431

L-Lysine-2HCl, [¹³C₆], lyophilized powder for SILAC

Catalog Number: (CAPI88431)
Supplier: Thermo Scientific
Description: Thermo Scientific Heavy and Light Amino Acids are used to specifically analyze protein expression by mass spectrometry using stable isotope labeling with amino acids in cell culture (SILAC) quantification kits.

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Image Unavailable-10081-468

Anti-RPS3 Rabbit Polyclonal Antibody

Catalog Number: (10081-468)
Supplier: Proteintech
Description: 40S ribosomal protein S3 (RPS3), also named as SW-cl.26, is a 243 amino acid protein,which contains one KH type-2 domain and belongs to the ribosomal protein S3P family. RPS3 localizes in the cytoplasm. RPS3 is identified in a IGF2BP1-dependent mRNP granule complex, which contains untranslated mRNAs. RPS3 plays a role in repairing various DNA damage acting as a repair UV endonuclease. Nuclear accumulation of RPS3 results in an increase in DNA repair activity to some extent, thereby sustaining neuronal survival.
Product Image-CAJT1266-5

Calcium acetate monohydrate 99.0-101.0%, powder, BAKER ANALYZED® ACS, J.T.Baker®

Supplier: AVANTOR PERFORMANCE MATERIAL LLC
Description: Powder. Lot analysis on label.

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Image Unavailable-CAAAB21060-36

Sodium dehydracetate 97%

Supplier: Thermo Scientific Chemicals
Description: Sodium dehydracetate 97%

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Image Unavailable-75791-394

Mouse Recombinant Siglec-3

Catalog Number: (75791-394)
Supplier: Prosci
Description: Mouse myeloid cell surface antigen CD33(CD33) is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD33 contains one Ig-like C2-type domain and one Ig-like V-type domain. CD33 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, CD33 may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33 induces apoptosis in acute myeloid leukemia. CD33 is becoming increasingly important as a target of antibody-mediated therapy in acute myeloid leukaemia (AML).
Image Unavailable-AAH63472-03

Methyl-2,5-difluoro-4-nitrobenzoate 95%

Supplier: Thermo Scientific Chemicals
Description: Methyl 2,5-difluoro-4-nitrobenzoate, 95%

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Product Image-10092-972

Anti-PSMD14 Rabbit Polyclonal Antibody

Catalog Number: (10092-972)
Supplier: Proteintech
Description: The PSMD14 (POH1, also known as Rpn11/MPR1/S13/CepP1) protein is a metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. PSMD14 is highly expressed in heart and skeletal muscle. In carcinoma cell lines. down-regulation of PSMD14 by siRNA transfection had a considerable impact on cell viability causing cell arrest in the G0-G1 phase, ultimately leading to senescence.
Image Unavailable-CA76634-008

Anti-TNF-alpha Mouse Monoclonal Antibody [clone: DBM15.28]

Supplier: Diagnostic Biosystems
Description: This MAb recognizes human 17 to 26kDa protein, which is identified as cytokine TNF-α (Tumor Necrosis Factor-alpha). Monomeric human TNF-α is a 157 amino acid protein (non-glycosylated) with a reported molecular weight of 17 kDa and can be expressed as a free molecule, also TNF-α is generated as a precursor form called transmembrane TNF-α can be expressed as a cell surface type II polypeptide consisting of 233 amino acid residues molecular weight 26 kDa. TNF-α is an important cell-signaling component of the immune system. It is a protein secreted by LPS stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF-α is currently being evaluated in treatment of certain cancers and AIDS Related Complex.

Image Unavailable-10072-610

Human Recombinant BMP2 (from E. coli)

Catalog Number: (10072-610)
Supplier: Prosci
Description: BMPs (Bone Morphogenetic Proteins) belong to the TGF-beta superfamily of structurally related signaling proteins. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains.
Image Unavailable-TCD4733-5G

2,4-Difluoro-6-nitroaniline ≥98.0% (by GC)

Catalog Number: (TCD4733-5G)
Supplier: TCI America
Description: 2,4-Difluoro-6-nitroaniline, Purity: >98.0%(GC), CAS Number: 364-30-7, Molecular Formula: C6H4F2N2O2, Molecular Weight: 174.11, Form: Crystal-Powder, Solid, Color: Pale yellow - Deep yellow, Size: 5G

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Image Unavailable-TCH0278-5G

3-Hydroxy-1,8-naphthalic anhydride ≥98.0% (by titrimetric analysis)

Catalog Number: (TCH0278-5G)
Supplier: TCI America
Description: CAS Number: 23204-36-6
MDL Number: MFCD00059759
Molecular Formula: C12H6O4
Molecular Weight: 214.18
Purity/Analysis Method: >98.0% (T)
Form: Crystal
Melting point (°C): 281

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Image Unavailable-10779-726

Human Recombinant IL-20 (from E. coli)

Supplier: Peprotech
Description: IL-20 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. IL-20 is a hematopoietic growth factor capable of stimulating colony formation by CD34+ multipotential progenitors, but not by other progenitor cells. IL-20 signals through a receptor system composed of type I IL-20Rα and type II IL-20Rβ. Over-expression of IL-20 in keratinocytes expressing both receptor subunits has been implicated in the induction of inflammatory skin disease. Recombinant Human IL-20 is a 35.2 kDa homodimeric protein consisting of two 153 amino acid polypeptide chains.

Image Unavailable-10084-298

Anti-CD22 Mouse Monoclonal Antibody [clone: 7A2F1]

Catalog Number: (10084-298)
Supplier: Proteintech
Description: CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule), is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.
Image Unavailable-CAAA30538-MD

Tetrasodium meso-tetra(sulfonatophenyl)porphine dodecahydrate ≥95%

Supplier: Thermo Scientific Chemicals
Description: Tetrasodium meso-tetra(sulfonatophenyl)porphine dodecahydrate ≥95%

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