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Description: 4-Benzyloxy-3-chlorophenylboronic Acid (contains varying amounts of Anhydride), CAS Number: 845551-44-2, Molecular Formula: C13H12BClO3, Synonyms: 4-Benzyloxy-3-chlorobenzeneboronic Acid (contains varying amounts of Anhydride), Size: 5G
Catalog Number: TCB5064-1G
Supplier: TCI America


Description: 6-FAM, SE (full name: 6-Carboxyfluorescein, succinimidyl ester, single isomer) is the amine-reactive form of 6-carboxyfluorescein single isomer.
6-FAM SE is an amine-reactive green fluorescent dye widely used for labeling oligonucleotides or other biomolecules that contain a primary or secondary aliphatic amine. The coupling reaction is usually carried out at pH 8-9.5.
Catalog Number: 89139-556
Supplier: Biotium


Description: CAS Number: 112440-47-8
MDL Number: MFCD00142789
Molecular Formula: C18H18O3S2
Molecular Weight: 346.46
Purity/Analysis Method: >97.0% (T)
Form: Crystal
Melting point (°C): 168
Catalog Number: TCB1534-100MG
Supplier: TCI America

SDS


Description: Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) >K(+) >Cs(+) >Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.Involvement in disease:Defects in TRPM4 are the cause of progressive familial heart block type 1B (PFHB1B) [MIM:604559]. It is a cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.
Catalog Number: 10666-194
Supplier: Bioss


Description: TRC delta2-Cefuroxime Axetil (Cefuroxime Axetil Delta-3 Isomer)
Catalog Number: 77979-702
Supplier: LGC Standards

New Product


Description: TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.
Catalog Number: 75980-852
Supplier: Biotium


Description: Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]
Catalog Number: 10352-504
Supplier: Bioss


Description: 5-Cyano-2-fluorophenylboronic Acid (contains varying amounts of Anhydride), CAS Number: 468718-30-1, Molecular Formula: C7H5BFNO2, Synonyms: 5-Cyano-2-fluorobenzeneboronic Acid (contains varying amounts of Anhydride), Size: 1G
Catalog Number: TCC3227-5G
Supplier: TCI America


Description: 2-Chloro-4-ethoxyphenylboronic Acid (contains varying amounts of Anhydride), CAS Number: 313545-44-7, Molecular Formula: C8H10BClO3, Synonyms: 2-Chloro-4-ethoxybenzeneboronic Acid (contains varying amounts of Anhydride), Size: 1G
Catalog Number: TCC3222-200MG
Supplier: TCI America


Description: CAS Number: 463-04-7
MDL Number: MFCD00036132
Molecular Formula: C5H11NO2
Molecular Weight: 117.15
Purity/Analysis Method: >95.0% (GC)
Form: Clear Liquid
Boiling point (°C): 104
Flash Point (°C): -18
Specific Gravity (20/20): 0.88
Storage Temperature: 0-10°C
Catalog Number: TCA0455-100ML
Supplier: TCI America

Description: CAS Number: 716-39-2
MDL Number: MFCD00059091
Molecular Formula: C12H6O3
Molecular Weight: 198.18
Purity/Analysis Method: >95.0% (GC,T)
Form: Crystal
Boiling point (°C): 380
Melting point (°C): 248
Catalog Number: TCN0530-025G
Supplier: TCI America

SDS


Description: MDL: MFCD00000437 Beilstein Registry No.: 1802113 Notes: 85% n-isomer
Catalog Number: CAAA15812-14
Supplier: Thermo Scientific Chemicals

Description: 2-Phenylethylboronic Acid, CAS Number: 34420-17-2, Molecular Formula: C8H11BO2, Molecular Weight: 149.98, Synonyms: Phenethylboronic Acid (contains varying amounts of Anhydride), Size: 1G
Catalog Number: TCP2476-5G
Supplier: TCI America

Description: TIMELESS1 (TIM1) gene encodes protein timeless homolog belonging to timeless family. TIM1 is localized in nucleus and regulated by cell cycle. It expresses high levels in S, G2 and M phases, and low in G0 and G1 phases. TIM1 is involved in the circadian rhythm autoregulatory loop and is a crucial component of the circadian core oscillator, which includes the CRY proteins, CLOCK, NPAS2, etc. It is also involved in cell survival after DNA damage or replication stress and reported to play important role in epithelial cell morphogenesis and formation of branching tubules.
Catalog Number: 10095-990
Supplier: Proteintech


Description: Dedicator of cytokinesis3 (DOCK3) , also named as MOCA and PBP , is a ~180 kDa protein involved in signaling trasduction. It is a potential guanine nucleotide exchange factor (GEF) which activate some small GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of Dock3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3β (GSK-3β) at the plasma membrane, thereby promoteing axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS.
Catalog Number: 10086-062
Supplier: Proteintech


Description: HiLyte™ Fluor 488 hydroxylamine is a carbonyl-reactive labeling dye, which reacts more readily with aldehydes at physiological pH than other primary amine-containing reagents (such as hydrazides and amines).
Catalog Number: 103006-524
Supplier: Anaspec Inc


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