Human Recombinant IL-21 (from E. coli)

Supplier: VWR International

Human Recombinant IL-21 (from <italic>E. coli</italic>)

Human Recombinant IL-21 (from <italic>E. coli</italic>)

77753-386 77753-388 77753-390

77753-386EA 2537.32 CAD

77753-386 77753-388 77753-390

Human Recombinant IL-21 (from E. coli)

Proteins and Peptides

IL-21 is a common chain cytokine regulating many cell types of the immune system. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Plays an important role in the development of humoral immunity through its effects on B cell biology including differentiation, affinity maturation, and memory responses. Regulates T cell responses including survival of CD8⁺ T cells and inhibition of Treg cells. IL-21 plays a pivotal role in Hodgkin’s lymphoma and suppresses contact hypersensitivity reactions.

High quality
Low endotoxin
Lot-to-lot consistency
Animal free
Manufactured following GMP guidelines

Promotes a less differentiated phenotype of CAR T cells while promoting the effector functions of the engineered cells. The biological activity of CTGrade GMP interleukins and growth factors is standardized, where applicable, to WHO International standards, providing cell and gene therapy developers consistent, lot-to-lot biological activity and performance.

Host cell protein: ≤30 ng/ml, Host cell DNA: ≤0.01 ng/ml, Sterility testing: No growth, Mycoplasma: Negative.

Caution: For research use or further manufacturing only.

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