Human Recombinant PDGF-AA (from E. coli)

Supplier: VWR International

VWR500-23-100UG VWR500-23-1MG VWR500-23-50UG
77753-416EA 2254.08 CAD
77753-416 77753-418 77753-420
Human Recombinant PDGF-AA (from E. coli)
Proteins and Peptides

Platelet-derived growth factor (PDGF) serves as a crucial controller of cell growth, proliferation, and angiogenesis. PDGF exists as a dimeric glycoprotein, comprising two polypeptide chains (A and B) stabilized by disulfide bridges. These chains can combine to form either heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) PDGF-AA is commonly used for differentiation of neural progenitor cells derived from human pluripotent stem cells (hPSC) into oligodendrocyte precursor cells.


  • High quality
  • Low endotoxin
  • Lot-to-lot consistency
  • Animal free
  • Manufactured following GMP guidelines


The synthesis of PDGF is stimulated by signaling molecules such as IL-1, IL-6, TNF-α, TGF-β, and EGF. PDGF acts as a growth hormone that induces cell division in mesenchymal lineage cells like smooth muscle and glial cells. Furthermore, PDGF is stored within the alpha-granules of platelets and is released when these platelets adhere to injured tissues. The PDGF dimer binds to cell surface receptor tyrosine kinases, specifically PDGFR-α and PDGFR-β. Studies suggest that PDGF-AA plays a pivotal role as an autocrine regulator of vascular endothelial growth factor (VEGF) expression in non-small cell lung carcinomas. Additionally, PDGF-AA facilitates the proliferation of oligodendrocyte progenitor cells and guides their differentiation along the oligodendrocyte lineage through the activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2).


Host cell protein: ≤30 ng/ml Host cell DNA: ≤0.01 ng/ml Sterility testing: No growth Mycoplasma: Negative


Caution: For research use or further manufacturing only.

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